Biography

Dr. Mohammad F. Kiani is Professor of the Department of Mechanical Engineering. Dr. Kiani’s expertise is in biofluid mechanics, targeted drug delivery, and radiation oncology. Dr. Kiani co-founded Engineering World Health with Dr. Robert Malkin, served as its president for several years, and currently serves on its board of directors.

Research Interests

  • Microfluidic Systems
  • Targeted Drug Delivery
  • Leukocyte Biology

Courses Taught

Number

Name

Level

MEE 4040

Special Topics: Design of Experiments

Undergraduate

MEE 4731

Cardiovascular Fluid Dynamics

Undergraduate

MEE 5110

Special Topics: Design of Experiments

Graduate

MEE 5731

Cardiovascular Fluid Dynamics

Graduate

ENGR 1101

Introduction to Engineering & Engineering Technology

Undergraduate

ENGR 1901

Honors Introduction to Engineering

Undergraduate

Selected Publications

  • Soroush, F., Tang, Y., Guglielmo, K., Engelmann, A., Liverani, E., Patel, A., Langston, J., Sun, S., Kunapuli, S., Kiani, M.F., & Kilpatrick, L.E. (2019). Protein Kinase C-Delta (PKCd) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. Shock (Augusta, Ga.), 51(5), pp. 538-547. doi: 10.1097/SHK.0000000000001247

  • Yang, Q., Langston, J.C., Tang, Y., Kiani, M.F., & Kilpatrick, L.E. (2019). The role of tyrosine phosphorylation of protein kinase C delta in infection and inflammation. International Journal of Molecular Sciences, 20(6). doi: 10.3390/ijms20061498

  • Soroush, F., Tang, Y., Zaidi, H.M., Sheffield, J.B., Kilpatrick, L.E., & Kiani, M.F. (2018). PKCd inhibition as a novel medical countermeasure for radiation-induced vascular damage. FASEB Journal, 32(12), pp. 6436-6444. doi: 10.1096/fj.201701099

  • Tang, Y., Soroush, F., Sun, S., Liverani, E., Langston, J.C., Yang, Q., Kilpatrick, L.E., & Kiani, M.F. (2018). Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage. Journal of Neuroinflammation, 15(1). doi: 10.1186/s12974-018-1342-y

  • Yang, F., Soroush, F., Deng, G., Yu, S., Chu, P., Kiani, M.F., & Ling, H. (2018). Multiple neutrophils tracking in vitro array using high-order temporal information. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2018-July, pp. 814-817. doi: 10.1109/EMBC.2018.8512342

  • Tang, Y., Soroush, F., Liverani, E., Sun, S., Langston, J.C., Kilpatrick, L.E., & Kiani, M.F. (2018). PROTEIN KINASE C-DELTA INHIBITION PROTECTS THE BRAIN FROM SEPSIS-INDUCED VASCULAR DAMAGE. SHOCK, 49(6), pp. 28-28. Retrieved from http://gateway.webofknowledge.com/

  • Soroush, F., Tang, Y., Sun, S., Langston, J., Kilpatrick, L.E., & Kiani, M.F. (2018). NEUTROPHIL-ENDOTHELIAL INTERACTIONS IN MICE DO NOT ALWAYS PREDICT THEIR INTERACTIONS IN HUMANS. SHOCK, 49(6), pp. 55-56. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Soroush, F., Sheffield, J.B., Wang, B., Prabhakarpandian, B., & Kiani, M.F. (2017). A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems. Scientific Reports, 7(1). doi: 10.1038/s41598-017-09815-9

  • Zheng, X., Soroush, F., Long, J., Hall, E.T., Adishesha, P.K., Bhattacharya, S., Kiani, M.F., & Bhalla, V. (2017). Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. PLoS ONE, 12(9). doi: 10.1371/journal.pone.0185250

  • Luca, R.D.e., Silvani, G., Scognamiglio, C., Sinibaldi, G., Peruzzi, G., Chinappi, M., Kiani, M.F., & Casciola, C.M. (2017). Towards cavitation-enhanced permeability in blood vessel on a chip. AIP Conference Proceedings, 1873. doi: 10.1063/1.4997139

  • Kiani, M.F., Soroush, F., Tang, Y., Prabhakarpandian, B., & Kilpatrick, L.E. (2017). MODELING PKC-DELTA REGULATION OF NEUTROPHIL-ENDOTHELIAL INTERACTIONS WITH A NOVEL MICROFLUIDICS DEVICE. SHOCK, 47(6), pp. 29-29. Retrieved from http://gateway.webofknowledge.com/

  • Kiani, M.F., Tang, Y., Soroush, F., Prabhakarpandian, B., & Kilpatrick, L.E. (2017). MICROVASCULAR NETWORK ON A CHIP. SHOCK, 47(6), pp. 25-25. Retrieved from http://gateway.webofknowledge.com/

  • Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. Cardiovascular Engineering and Technology, 8(1), pp. 70-80. doi: 10.1007/s13239-016-0289-3

  • Tang, Y., Soroush, F., Tong, Z., Kiani, M.F., & Wang, B. (2017). Targeted multidrug delivery system to overcome chemoresistance in breast cancer. International Journal of Nanomedicine, 12, pp. 671-681. doi: 10.2147/IJN.S124770

  • Soroush, F., Zhang, T., King, D.J., Tang, Y., Deosarkar, S., Prabhakarpandian, B., Kilpatrick, L.E., & Kiani, M.F. (2016). A novel microfluidic assay reveals a key role for protein kinase C d in regulating human neutrophil-endothelium interaction. Journal of Leukocyte Biology, 100(5), pp. 1027-1035. doi: 10.1189/jlb.3MA0216-087R

  • Tang, Y., Wang, Y., Kiani, M.F., & Wang, B. (2016). Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer. Clinical Breast Cancer, 16(5), pp. 335-343. doi: 10.1016/j.clbc.2016.05.012

  • Tang, Y., Soroush, F., Deosarkar, S., Wang, B., Prabhakarpandian, B., & Kiani, M. (2016). A physiological model of the tumor microenvironment for screening drug delivery systems. CANCER RESEARCH, 76. doi: 10.1158/1538-7445.AM2016-3382

  • Soroush, F., Tang, Y., Deosarkar, S., Pandian, P., Kilpatrick, L.E., & Kiani, M.F. (2016). THE ROLE OF PKC delta IN HUMAN NEUTROPHIL-ENDOTHELIAL INTERACTIONS DURING ACUTE INFLAMMATION. SHOCK, 45(6), pp. 62-62. Retrieved from http://gateway.webofknowledge.com/

  • Soroush, F., Tang, Y., Pandian, P., Kilpatrick, L.E., & Kiani, M.F. (2016). A Novel Bioinspired Microfluidic Assay for Investigation of the Role of Protein Kinase C-delta (PKC delta) in Human Neutrophil-Endothelium Interaction During Acute Inflammation. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Deosarkar, S.P., Prabhakarpandian, B., Wang, B., Sheffield, J., Krynska, B., & Kiani, M. (2016). A Novel Neonatal Blood-Brain Barrier on a Chip Closely Approximates the In Vivo Microenvironment. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Soroush, F., Deosarkar, S., Wang, B., Pandian, P., & Kiani, M.F. (2016). A Novel Synthetic Tumor Platform for Screening Drug Delivery systems. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Zheng, X., Soroush, F., Hall, E., Adishesha, P., Bhattacharya, S., Kiani, M., & Bhalla, V. (2016). Dynamic Regulation of Endothelial Cell-Specific Molecule 1 in Diabetic Mouse Kidney. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Deosarkar, S.P., Prabhakarpandian, B., Wang, B., Sheffield, J.B., Krynska, B., & Kiani, M.F. (2015). A novel dynamic neonatal blood-brain barrier on a chip. PLoS ONE, 10(11). doi: 10.1371/journal.pone.0142725

  • Soroush, F., Pandian, P., Kilpatrick, L., & Kiani, M. (2015). A Bioinspired Microfluidic Assay for Investigation of the Role of Protein Kinase C-delta on Leukocyte-endothelial interactions in Sepsis. FASEB JOURNAL, 29. Retrieved from http://gateway.webofknowledge.com/

  • Lamberti, G., Soroush, F., Smith, A., Kiani, M.F., Prabhakarpandian, B., & Pant, K. (2015). Adhesion patterns in the microvasculature are dependent on bifurcation angle. Microvascular Research, 99, pp. 19-25. doi: 10.1016/j.mvr.2015.02.004

  • Tang, Y., Wang, Y., Deosarkar, S., Soroush, F., Kiani, M.F., & Wang, B. (2015). Fast, stable induction of P-glycoprotein-mediated drug resistance in BT-474 breast cancer cells by stable transfection of ABCB1 gene. Anticancer Research, 35(5), pp. 2531-2538.

  • Hemmasizadeh, A., Tsamis, A., Cheheltani, R., Assari, S., D'Amore, A., Autieri, M., Kiani, M.F., Pleshko, N., Wagner, W.R., Watkins, S.C., Vorp, D., & Darvish, K. (2015). Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. Journal of the Mechanical Behavior of Biomedical Materials, 47, pp. 12-20. doi: 10.1016/j.jmbbm.2015.03.004

  • Li, H., Mirizio, E., Rajasimhan, S., Qian, B., Baranowitz, S., Kiani, M.F., & Ren, F. (2014). Evaluation of temperature dependent electrical properties for hydrated natural melanins. MOLECULAR BIOLOGY of the CELL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Mirizio, E., Rajasimhan, S., Li, H., Qian, B., Kiani, M.F., Ren, F., & Baranowitz, S.A. (2014). Investigation of the electrical properties of doped melanin. MOLECULAR BIOLOGY of the CELL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Lamberti, G., Kiani, M.F., & Wang, B. (2014). Characterization of particle-endothelium interaction using particles functionalized with dual antibodies in a complex synthetic microvascular network. MOLECULAR BIOLOGY of the CELL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Deosarkar, S.P., Augelli, B., Prabhakarpandian, B., Krynska, B., & Kiani, M.F. (2014). Development of a Novel, Physiologically and Anatomically Realistic in vitro Pediatric Blood Brain Barrier on a Chip. MOLECULAR BIOLOGY of the CELL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Gan, X., Cheheltani, R., Curran, E., Lamberti, G., Krynska, B., Kiani, M.F., & Wang, B. (2014). Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model. Nanomedicine: Nanotechnology, Biology, and Medicine, 10(8), pp. 1711-1718. doi: 10.1016/j.nano.2014.06.001

  • Lamberti, G., Prabhakarpandian, B., Garson, C., Smith, A., Pant, K., Wang, B., & Kiani, M.F. (2014). Bioinspired microfluidic assay for in vitro modeling of leukocyte-endothelium interactions. Analytical Chemistry, 86(16), pp. 8344-8351. doi: 10.1021/ac5018716

  • Cheheltani, R., McGoverin, C.M., Rao, J., Vorp, D.A., Kiani, M.F., & Pleshko, N. (2014). Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta. Analyst, 139(12), pp. 3039-3047. doi: 10.1039/c3an02371k

  • Lamberti, G., Prabhakarpandian, B., Smith, A., Pant, K., Wang, B., & Kiani, M. (2014). Microfluidic device and assay for mimicking the leukocyte-endothelium interactions in vivo. FASEB JOURNAL, 28(1). Retrieved from http://gateway.webofknowledge.com/

  • Lamberti, G., Smith, A., Kiani, M., Prabhakarpandian, B., & Pant, K. (2014). Drug carrier particle adhesion depends on bifurcation angle. FASEB JOURNAL, 28(1). Retrieved from http://gateway.webofknowledge.com/

  • Hooshdaran, B., Kolpakov, M., Rafiq, K., Guo, X., Kiani, M., & Sabri, A. (2014). Targeting inflammatory serine proteases for cardiac repair after Ischemia Reperfusion injury. FASEB JOURNAL, 28(1). Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Lamberti, G., Curran, E., Kiani, M., & Wang, B. (2014). Development and characterization of a multi-drug resistant Her-2/neu positive breast cancer cell line. FASEB JOURNAL, 28(1). Retrieved from http://gateway.webofknowledge.com/

  • Lamberti, G., Tang, Y., Kiani, M., & Wang, B. (2014). Characterization of particle-endothelium interaction using particles functionalized with dual antibodies in a complex synthetic microvascular network. FASEB JOURNAL, 28(1). Retrieved from http://gateway.webofknowledge.com/

  • Soroush, F., Lampberti, G., Prabhakarpandian, B., Garson, C., Smith, A., Pant, K., Wang, B., & Kiani, M.F. (2014). A novel microfluidic assay for in vitro modeling of leukocyte-endothelium interactions. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, pp. 2504-2505.

  • Baran, G.R., Kiani, M.F., & Samuel, S.P. (2014). Healthcare and biomedical technology in the 21st century: An introduction for non-science majors. (pp. 1-503). doi: 10.1007/978-1-4614-8541-4