Biography
Dr. Karin Wang is an Assistant Professor of Bioengineering at Temple University. Her research program leverages principles from tissue engineering, biomaterials science, soft matter physics, and cell biology to engineer reductionist model systems that probe cell and matrix dynamics. The interdisciplinary approaches used in her lab are aimed at enhancing our fundamental understanding of structure-function relationships from the molecular to multicellular level, to understand how physical forces regulate cell-matrix interactions in health and disease.
Dr. Karin Wang received her BS in Applied Math and Statistics and BE/MS in Biomedical Engineering from Stony Brook University in 2010. She received her PhD in Biomedical Engineering from Cornell University in 2015, studying how the materials properties of matrix proteins drive tumor progression and was awarded NSF DGE GK-12 Teaching Fellowships. During her postdoctoral training from 2015-2018 to investigate the underlying physical drivers of collective cellular migration, she was a NIH NCI F32 Postdoctoral Fellow in the Molecular and Integrative Physiological Sciences Program in the T.H. Chan School of Public Health at Harvard University.
Labs: Research Website
Google Scholar: Publications
Research Interests
- Cell and matrix mechanobiology
Structure-function relationships
Collective migration
Extracellular matrix remodeling
Tissue engineered model systems
Courses Taught
|
Number |
Name |
Level |
|---|---|---|
|
BIOE 0844 |
The Bionic Human |
Undergraduate |
|
BIOE 2001 |
Frontiers in Bioengineering |
Undergraduate |
|
BIOE 2101 |
Engineering Principles of Physiological Systems |
Undergraduate |
|
BIOE 4500 |
Special Topics: Mechanobiology |
Undergraduate |
|
BIOE 5500 |
Special Topics: Mechanobiology |
Graduate |
|
BIOE 5600 |
Bioengineering Graduate Seminar |
Graduate |
Selected Publications
Featured
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Seo, B.R., Chen, X., Ling, L., Song, Y.H., Shimpi, A.A., Choi, S., Gonzalez, J., Sapudom, J., Wang, K., Eguiluz, R., Gourdon, D., Shenoy, V.B., & Fischbach, C. (2020). Collagen microarchitecture mechanically controls myofibroblast differentiation. Proceedings of the National Academy of Sciences of the United States of America, 117(21). doi: 10.1073/pnas.1919394117
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Kim, J.H., Pegoraro, A.F., Das, A., Koehler, S.A., Ujwary, S.A., Lan, B., Mitchel, J.A., Atia, L., He, S., Wang, K., Bi, D., Zaman, M.H., Park, J.A., Butler, J.P., Lee, K.H., Starr, J.R., & Fredberg, J.J. (2020). Unjamming and collective migration in MCF10A breast cancer cell lines. Biochemical and Biophysical Research Communications, 521(3), pp. 706-715. doi: 10.1016/j.bbrc.2019.10.188
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Patten, J. & Wang, K. (2020). Fibronectin in development and wound healing. Advanced Drug Delivery Reviews. doi: 10.1016/j.addr.2020.09.005
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Wang, K., Wu, F., Seo, B.o.R.i., Fischbach, C., Chen, W., Hsu, L., & Gourdon, D. (2017). Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions. Matrix Biol, 60-61, pp. 86-95. Netherlands. doi: 10.1016/j.matbio.2016.08.001
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Wang, K., Cai, L., Lan, B.o., & Fredberg, J.J. (2016). Hidden in the mist no more: physical force in cell biology. Nat Methods, 13(2), pp. 124-125. United States. doi: 10.1038/nmeth.3744
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Wang, K., Seo, B.o.R.i., Fischbach, C., & Gourdon, D. (2016). Fibronectin Mechanobiology Regulates Tumorigenesis. Cell Mol Bioeng, 9, pp. 1-11. United States. doi: 10.1007/s12195-015-0417-4
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Seo, B.o.R.i., Bhardwaj, P., Choi, S., Gonzalez, J., Eguiluz, R.C.A., Wang, K., Mohanan, S., Morris, P.G., Du, B., Zhou, X.i.K., Vahdat, L.T., Verma, A., Elemento, O., Hudis, C.A., Williams, R.M., Gourdon, D., Dannenberg, A.J., & Fischbach, C. (2015). Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci Transl Med, 7(301), p. 301ra130. United States. doi: 10.1126/scitranslmed.3010467
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Wang, K., Eguiluz, R.C.A., Wu, F., Seo, B.o.R.i., Fischbach, C., & Gourdon, D. (2015). Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells. Biomaterials, 54, pp. 63-71. Netherlands. doi: 10.1016/j.biomaterials.2015.03.019
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D'Alfonso, T.M., Wang, K., Chiu, Y., & Shin, S.J. (2013). Pathologic upgrade rates on subsequent excision when lobular carcinoma in situ is the primary diagnosis in the needle core biopsy with special attention to the radiographic target. Arch Pathol Lab Med, 137(7), pp. 927-935. United States. doi: 10.5858/arpa.2012-0297-OA
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Hashi, C.K., Zhu, Y., Yang, G., Young, W.L., Hsiao, B.S., Wang, K., Chu, B., & Li, S. (2007). Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proc Natl Acad Sci U S A, 104(29), pp. 11915-11920. United States. doi: 10.1073/pnas.0704581104
Recent
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Krohn-Grimberghe, M., Mitchell, M.J., Schloss, M.J., Khan, O.F., Courties, G., Guimaraes, P., Rohde, D., Cremer, S., Kowalski, P.S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S.P., Wojtkiewicz, G.R., Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F.F., Swirski, F.K., Langer, R., Anderson, D.G., & Nahrendorf, M. (2020). Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering, 4(11), pp. 1076-1089. doi: 10.1038/s41551-020-00623-7
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Guimaraes, P., Tan, M., Tammela, T., Wu, K., Chung, A., Oberli, M., Wang, K., Spektor, R., Riley, R.S., Viana, C., Jacks, T., Langer, R., & Mitchell, M.J. (2018). Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Journal of Controlled Release, 290, pp. 75-87. doi: 10.1016/j.jconrel.2018.09.025