Karin Wang

Karin Wang

  • College of Engineering

    Bioengineering

    Assistant Professor

Office Location

College of Engineering Building Room 806

Phone

215-204-3751

Biography

Dr. Karin Wang is an Assistant Professor in the Department of Bioengineering at Temple College of Engineering. Prior to joining Temple, Dr. Wang worked as a Postdoctoral Fellow in the Program of Molecular and Integrative Physiological Sciences of the Department of Environmental Health at Harvard University. She received her PhD in Biomedical Engineering in 2015 from Cornell University. Her main research interest is in cell and matrix mechanobiology.  Specifically, she is integrating principles from tissue engineering, biomaterials science, physics, and cell biology to develop model systems and tools that probe cell-matrix interactions for biomedical applications. Using this interdisciplinary approach, the Wang Lab aims to identify and regulate the key mechanobiological drivers of a range of human diseases, with a particular focus on cancer metastasis.

Labs: Research Website

Google Scholar: Publications

Research Interests

  • Cell and matrix mechanobiology
    Collective migration
    Extracellular matrix remodeling
    Tissue engineered model systems

Courses Taught

Number

Name

Level

BIOE 0844

The Bionic Human

Undergraduate

BIOE 2001

Frontiers in Bioengineering

Undergraduate

BIOE 2101

Engineering Principles of Physiological Systems

Undergraduate

Selected Publications

Featured

  • Wang, K., Wu, F., Seo, B.o.R.i., Fischbach, C., Chen, W., Hsu, L., & Gourdon, D. (2017). Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions. Matrix Biol, 60-61, pp. 86-95. Netherlands. doi: 10.1016/j.matbio.2016.08.001

  • Wang, K., Cai, L., Lan, B.o., & Fredberg, J.J. (2016). Hidden in the mist no more: physical force in cell biology. Nat Methods, 13(2), pp. 124-125. United States. doi: 10.1038/nmeth.3744

  • Wang, K., Seo, B.o.R.i., Fischbach, C., & Gourdon, D. (2016). Fibronectin Mechanobiology Regulates Tumorigenesis. Cell Mol Bioeng, 9, pp. 1-11. United States. doi: 10.1007/s12195-015-0417-4

  • Seo, B.o.R.i., Bhardwaj, P., Choi, S., Gonzalez, J., Eguiluz, R.C.A., Wang, K., Mohanan, S., Morris, P.G., Du, B., Zhou, X.i.K., Vahdat, L.T., Verma, A., Elemento, O., Hudis, C.A., Williams, R.M., Gourdon, D., Dannenberg, A.J., & Fischbach, C. (2015). Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci Transl Med, 7(301), p. 301ra130. United States. doi: 10.1126/scitranslmed.3010467

  • Wan, A.M., Inal, S., Williams, T., Wang, K., Leleux, P., Estevez, L., Giannelis, E.P., Fischbach, C., Malliaras, G.G., & Gourdon, D. (2015). 3D Conducting Polymer Platforms for Electrical Control of Protein Conformation and Cellular Functions. J Mater Chem B, 3(25), pp. 5040-5048. England. doi: 10.1039/C5TB00390C

  • Wang, K., Eguiluz, R.C.A., Wu, F., Seo, B.o.R.i., Fischbach, C., & Gourdon, D. (2015). Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells. Biomaterials, 54, pp. 63-71. Netherlands. doi: 10.1016/j.biomaterials.2015.03.019

  • D'Alfonso, T.M., Wang, K., Chiu, Y., & Shin, S.J. (2013). Pathologic upgrade rates on subsequent excision when lobular carcinoma in situ is the primary diagnosis in the needle core biopsy with special attention to the radiographic target. Arch Pathol Lab Med, 137(7), pp. 927-935. United States. doi: 10.5858/arpa.2012-0297-OA

  • Hashi, C.K., Zhu, Y., Yang, G., Young, W.L., Hsiao, B.S., Wang, K., Chu, B., & Li, S. (2007). Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proc Natl Acad Sci U S A, 104(29), pp. 11915-11920. United States. doi: 10.1073/pnas.0704581104

Recent

  • Guimaraes, P.P.G., Tan, M., Tammela, T., Wu, K., Chung, A., Oberli, M., Wang, K., Spektor, R., Riley, R.S., Viana, C.T.R., Jacks, T., Langer, R., & Mitchell, M.J. (2018). Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. JOURNAL of CONTROLLED RELEASE, 290, pp. 75-87. doi: 10.1016/j.jconrel.2018.09.025

  • Wang, K., Eguiluz, R., Wu, F., Seo, B.R., Benson, V., Brown, C.N., Fischbach, C., & Gourdon, D. (2014). Altered unfolding and stiffening of fibronectin for tumor progression. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2014-December. doi: 10.1109/NEBEC.2014.6972970