Bojana Gligorijevic

Bojana Gligorijevic

  • College of Engineering

    Bioengineering

    Associate Professor

  • Fox Chase Cancer Center

    Honorary Associate Professor

  • Lewis Katz School of Medicine

    Fels Cancer Institute for Personalized Medicine

    Associate Professor

Office Location

Engineering 810

Phone

215-204-3883

Biography

Bojana Gligorijevic, PhD, graduated Chemistry at University of Belgrade with an honors thesis in analytical chemistry, isolating active compounds from endemic plants. At Georgetown University, Dr. Gligorijevic’s PhD chemistry thesis took a turn when she first saw a fluorescent microscope. She ended up developing new technologies for automated 4D imaging and analysis of malaria division and metabolic processes. During her postdoctoral training in cancer biology at Albert Einstein College of Medicine, she developed new tools for intravital imaging in mouse models and contributed to the current view of tumor cell intravasation mechanism in tumor microenvironment context.

Labs: Cancer Microscopy & Mechanobiology Lab

Research Interests

  • Intravital imaging
  • Multiphoton Microscopy
  • Machine Learning Image Classification
  • Fluorescent Proteins
  • Cancer Complexity
  • Cell Decision-making
  • Extracellular Matrix Remodeling
  • Tumor Microenvironments
  • Mouse Models of Metastasis
  • Invadopodia
  • Motility & Invasion.

Courses Taught

Number

Name

Level

BIOE 0856

Ethical Issues in Biomedical Science, Engineering and Technology

Undergraduate

BIOE 4555

Capstone Elective - Biophotonics: Seeing is Believing

Undergraduate

BIOE 5555

Biophotonics: Seeing is Believing

Graduate

Selected Publications

Featured

  • Pourfarhangi, K.E., Hoz, E.C.D.e.L.a., Cohen, A.R., & Gligorijevic, B. (2018). Contact guidance is cell cycle-dependent. APL Bioeng, 2(3). United States. doi: 10.1063/1.5026419

  • Pourfarhangi, K.E., Bergman, A., & Gligorijevic, B. (2018). ECM Cross-Linking Regulates Invadopodia Dynamics. Biophys J, 114(6), pp. 1455-1466. United States. doi: 10.1016/j.bpj.2018.01.027

  • Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., & Gligorijevic, B. (2018). Intravital Imaging of Tumor Cell Motility in the Tumor Microenvironment Context. Methods Mol Biol, 1749, pp. 175-193. United States. doi: 10.1007/978-1-4939-7701-7_14

  • Tönisen, F., Perrin, L., Bayarmagnai, B., Dries, K.v.d., Cambi, A., & Gligorijevic, B. (2017). EP4 receptor promotes invadopodia and invasion in human breast cancer. Eur J Cell Biol, 96(2), pp. 218-226. Germany. doi: 10.1016/j.ejcb.2016.12.005

  • Bergman, A. & Gligorijevic, B. (2015). Niche construction game cancer cells play. Eur Phys J Plus, 130(10). Germany. doi: 10.1140/epjp/i2015-15203-5

Recent

  • Ogier, C., Solomon, A.M.C., Lu, Z., Recoules, L., Klochkova, A., Gabitova-Cornell, L., Bayarmagnai, B., Restifo, D., Surumbayeva, A., Vendramini-Costa, D.B., Deneka, A.Y., Francescone, R., Lilly, A.C., Sipman, A., Gardiner, J.C., Luong, T., Franco-Barraza, J., Ibeme, N., Cai, K.Q., Einarson, M.B., Nicolas, E., Efimov, A., Megill, E., Snyder, N.W., Bousquet, C., Cros, J., Zhou, Y., Golemis, E.A., Gligorijevic, B., Soboloff, J., Fuchs, S.Y., Cukierman, E., & Astsaturov, I. (2023). Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6). BioRxiv. United States. doi: 10.1101/2023.09.15.557802

  • Perrin, L. & Gligorijevic, B. (2022). Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer. Phys Biol, 20(1). England. doi: 10.1088/1478-3975/aca0d8

  • Perrin, L., Belova, E., Bayarmagnai, B., Tüzel, E., & Gligorijevic, B. (2022). Invadopodia enable cooperative invasion and metastasis of breast cancer cells. Commun Biol, 5(1), p. 758. England. doi: 10.1038/s42003-022-03642-z

  • Perrin, L., Bayarmagnai, B., Tuzel, E., & Gligorijevic, B. (2021). Invadopodia enable cooperative invasion and metastasis of breast cancer cells. doi: 10.21203/rs.3.rs-632734/v1

  • Perrin, L., Belova, E., Bayarmagnai, B., Tüzel, E., & Gligorijevic, B. (2021). Invadopodia enable cooperative invasion and metastasis of breast cancer cells. doi: 10.1101/2021.02.13.431047

  • Perrin, L., Tucker, T., & Gligorijevic, B. (2021). Time-Resolved Fluorescence Imaging and Analysis of Cancer Cell Invasion in the 3D Spheroid Model. J Vis Exp.(167). United States. doi: 10.3791/61902

  • Firestein, R., Marcinkiewicz, C., Nie, L., Chua, H.K., Quesada, I.V., Torelli, M., Sternberg, M., Gligorijevic, B., Shenderova, O., Schirhagl, R., & Feuerstein, G.Z. (2021). Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids. Nanotechnol Sci Appl, 14, pp. 139-159. New Zealand. doi: 10.2147/NSA.S321725

  • Gligorijevic, B. (2020). Real-time, high-resolution microscopy of invasive cancer cells in the tumor microenvironment context. J Biomol Tech, 31(Suppl), p. S40. United States. Retrieved from https://www.ncbi.nlm.nih.gov/

  • Perrin, L., Bayarmagnai, B., & Gligorijevic, B. (2020). Frontiers in Intravital Multiphoton Microscopy of Cancer. Cancer Rep (Hoboken), 3(1), p. e1192. United States. doi: 10.1002/cnr2.1192

  • Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., Graña, X., Tüzel, E., & Gligorijevic, B. (2019). Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle. J Cell Sci, 132(20). England. doi: 10.1242/jcs.227116

  • Pourfarhangi, K.E., Bergman, A., & Gligorijevic, B. (2019). Invadopodia Dynamics is Regulated by ECM Cross-Linking. BIOPHYSICAL JOURNAL, 116(3), pp. 414A-414A. Retrieved from http://gateway.webofknowledge.com/

  • Pourfarhangi, K.E. & Gligorijevic, B. (2019). Machine Learning Classification of Cancer Cells Migration in 3D Multi-cue Microenvironments 1. 2018 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2018 - Proceedings. doi: 10.1109/SPMB.2018.8615608

  • Bayarmagnai, B., Perrin, L., Pourfarhangi, K.E., & Gligorijevic, B. (2018). lnvadopodia are enriched in the G1 phase of the cell cycle. MOLECULAR BIOLOGY of the CELL, 29(26), pp. 227-227. Retrieved from http://gateway.webofknowledge.com/

  • Pourfarhangi, K.E., Bayarmagnai, B., Perrin, L., & Gligorijevic, B. (2018). Integrin beta 1 is the master regulator of the Invadopodia state in breast carcinoma cells. MOLECULAR BIOLOGY of the CELL, 29(26). Retrieved from http://gateway.webofknowledge.com/

  • Perrin, L. & Gligorijevic, B. (2018). EMT is decoupled from invadopodia and metastasis. MOLECULAR BIOLOGY of the CELL, 29(26), pp. 225-226. Retrieved from http://gateway.webofknowledge.com/

  • Pourfarhangi, K.E., Hoz, E.C.D.e.L.a., Cohen, A.R., & Gligorijevic, B. (2018). Contact guidance is cell cycle-dependent. MOLECULAR BIOLOGY of the CELL, 29(26). Retrieved from http://gateway.webofknowledge.com/

  • Soboloff, J., Gligorijevic, B., & Zaidi, M.R. (2018). STIM1 (c)AMPs up melanogenesis. EMBO J, 37(5). England. doi: 10.15252/embj.201899047

  • Bergman, A. & Gligorijevic, B. (2018). Real-time imaging of invadopodia in tumor microenvironment context. Optics InfoBase Conference Papers, Part F89-MICROSCOPY 2018. doi: 10.1364/MICROSCOPY.2018.MF3A.3

  • Pourfarhangi, K.E., Bayarmagnai, B., Hoz, E.C.d.e.l.a., Cohen, A., & Gligorijevic, B. (2018). A methodology to investigate the relationship between cancer cells cell-cycle phase and their migratory behaviors. Optics InfoBase Conference Papers, Part F91-TRANSLATIONAL 2018. doi: 10.1364/TRANSLATIONAL.2018.JTu3A.13