Date: 11/15/2013, Time: 12:00-01:00 pm,
Location: 809 Engineering Bldg
Speaker: Jason A. Burdick, PhD, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA
Title: Injectable Hydrogels that Provide both Mechanical and Biological Signals in Cardiac Repair
Abstract: Heart disease is a major clinical problem in the United States and post myocardial infarction (MI), left ventricular (LV) remodeling ensues and leads to geometric changes that result in dilation and thinning of the myocardial wall. This increases stress in the infarct and healthy tissue and can ultimately result in heart failure. Injectable biomaterials are being investigated to address this clinical problem, including to alter stresses in the infarct region when injected as an array and to deliver biologics, such as stem cells and biomolecules. We are interested in a class of hydrogels based on the molecule hyaluronic acid (HA). HA is found during cardiac development and is involved in numerous biological functions, such as morphogenesis and wound healing, and importantly, can be modified with reactive groups (e.g., methacrylates) to form hydrogels. We have synthesized variations of HA macromers that form hydrogels with a range of mechanical properties and degradation (from a few weeks to stable over many months) and that form hydrogels through either photoinitiated or red-dox initiated radical polymerizations. This tunability in properties allows us to investigate how material properties (e.g., mechanics and degradation) influence the ability of injectable HA hydrogels to alter stress profiles and LV remodeling and to deliver therapeutic molecules (e.g., stromal-derived factor 1-alpha and TIMP-3, to alter progenitor cell homing to and matrix remodeling within infarcts, respectively). Furthermore, we are now designing self-assembling and shear-thinning hydrogels for percutaneous delivery to the heart. Our ability to design materials with controlled properties and degradation is allowing us to investigate how engineered hydrogels can be used to alter cardiac outcomes by adjusting endogenous signals. Overall, these hydrogels provide us the opportunity to investigate diverse and controlled material properties for a range of biomedical applications. Click
Date: 11/18/2013, Time: 12:00-01:00 pm,
Location: 809 Engineering Bldg
Speaker: Thomas Gilbert, PhD, VP Research and Development, ACell, Inc., Columbia, MD
Title:Decellularized extracellular matrix scaffolds have been studied extensively over the past few decades, and have recently played an exciting role in the emergence of whole organ engineering. While care is taken to ensure removal of cellular components, there is a lack of understanding about how the methods used for removal of cellular components impacts the host remodeling response to the scaffold. The talk will particularly apply the discussion of these principles to cardiac and airway applications.
Speaker's Bio: Dr. Gilbert received his BS (Mater. Sci. Eng.) from Carnegie Mellon University and PhD (Bioengineering) from the University of Pittsburgh. He is currently Vice President of Research and Development at ACell, Inc. and an Adjunct Assistant Professor at the University of Pittsburgh. Previously, he served as an Assistant Professor of Surgery, Cardiothoracic Surgery, and Bioengineering at the University of Pittsburgh and was a faculty member of the McGowan Institute for Regenerative Medicine. His research includes the study of processing and use of extracellular matrix scaffold materials (including urinary bladder matrix) for development of regenerative medicine strategies in a variety of body systems. Dr. Gilbert has co-authored more than fifty peer-reviewed articles, several book chapters, and has applied for several patents related to ECM technology. His funding sources included the National Institutes of Health and the National Science Foundation. He has also worked as an Metallurgist for the Perryman Company in Houston, PA. Dr. Gilbert has a BS in Materials Science and Engineering from Carnegie Mellon University and a PhD in Bioengineering from the University of Pittsburgh. Click
Date: 11/22/2013, Time: 12:00-01:00 pm,
Location: 809 Engineering Bldg
Speaker: Ann M. Valentine, PhD, Department of Chemistry, Temple University, Philadelphia, PA
Title: Titanium Minerals and Biochemistry
Abstract: Titanium is the ninth most abundant element in the earth’s crust, and titanium minerals are widespread, yet conventional wisdom holds that biology has very little to do with titanium. The element has a reputation for inertness that is belied by data from several experimental systems. This talk will address some interactions between titanium minerals and biology at the molecular level, and will examine cases in which organisms and/or biomolecules induce, bind, or dissolve titanium minerals.
Speaker's Bio: Dr. Ann Valentine received her BS degree in chemistry from the University of Virginia (1993) and her PhD degree from the Massachusetts Institute of Technology (1998) working with Dr. Stephen Lippard. She conducted postdoctoral training as an NIH Postdoc Fellow at Penn. State University between 1998-2001 and started her independent career in the Department of Chemistry at Yale University. At Yale, she was promoted to Associate Professor in 2007 and now she is an Associate Professor in the Department of Chemistry at Temple University. Her research interests include the biochemistry, inorganic chemistry, and biomineralization of the element titanium (Ti). Click
Bioengineering at Temple University
Bioengineers graduating from our program will be individuals with a solid foundation in not only engineering but also physical and life sciences. Students and researchers going through our department will acquire a strong sense about translational biomedical research as well. Our students and trainees will be exposed to both basic and applied knowledge from diverse areas of engineering and sciences, such as thermodynamics, biomechanics, bioinformatics, bioimaging, bioprocessing, fluid mechanics, polymer chemistry, biomaterials, and cellular, molecular and regenerative engineering.
This knowledge will enable our graduates to join and lead interdisciplinary teams of engineers, scientists and clinicians to solve fundamental problems in the world around us. These problems include the design of innovative smart biomaterials, tissue constructs, medical devices and diagnostic technologies,and other areas that improve the quality of global health care and the standard of living throughout the world. Temple's Bioengineering Department has a strong focus in understanding human biology and associated diseases and injuries to ultimately invent engineering solutions to improve our status quo.
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