By Cheryl_Sharp
6/16/15

Won Suh, Ph.D., received the "Best of BIOT" award for his presentation at the 249th American Chemical Society's national meeting, Division of Biochemical Technology.



Temple Bioengineering Assistant Professor, Won Suh, Ph.D., received the "Best of BIOT" award for his presentation at the 249th American Chemical Society's National Meeting, Division of Biochemical Technology. The meeting was held in Denver, CO from March 22 to March 26. Dr. Suh's presentation, "Cell penetrating peptides for stem cell applications," discussed the results from specific molecular delivery experiments involving model bioactive peptides and lipids. Dr. Suh has been invited to participate in the "The Best of BIOT" webinar series that highlights speakers from the most recent meeting. Dr. Suh's webinar is scheduled for September 30th.

More information about the webinars can be found at http://www.acsbiot.org/.

Direct URL http://www.premierwebinars.com/EmergingTech-QBD.html

Abstract

The lengths of cell penetrating peptides (CPPs) derived from HIV-1 transcriptional activator (TAT) or Antennapedia homeodomain (Antp) typically range from 30-50 amino acids and such lengths can lead to preparative challenges since solid phase peptide synthesis (SPPS) methods are (commonly) utilized. We invented a new short CPP (<10-mer) that cell penetrates and can deliver bioactive molecules such as lipid and peptides. The new peptide system (PepB) increased solubility as well as cell incorporating capabilities but with decreased cellular toxicity. We will present results from specific molecular delivery experiments involving model bioactive peptides and lipids. We will discuss the utilization of PepB-technology in the differentiation of adult neural stem cells into neuronal cells via microscopy and RT-qPCR results. We envision the utilization of PepB-incorporating bioactive molecules as potential cellular tagging agents as well as vehicles for molecular delivery and stem cell applications.

Image Caption: Differentiated Stem Cells with Cell Penetrating Peptides Incorporated