Bojana Gligorijevic
Bojana Gligorijevic
Assistant Professor
Department: Bioengineering

Biography

Bojana Gligorijevic, PhD, graduated Chemistry at University of Belgrade with an honors thesis in analytical chemistry, isolating active compounds from endemic plants. At Georgetown University, Dr. Gligorijevic’s PhD chemistry thesis took a turn when she first saw a fluorescent microscope. She ended up developing new technologies for automated 4D imaging and analysis of malaria division and metabolic processes. During her postdoctoral training in cancer biology at Albert Einstein College of Medicine, she developed new tools for intravital imaging in mouse models and contributed to the current view of tumor cell intravasation mechanism in tumor microenvironment context.

Lab: Microscopy of Complex Environments (MiCE)

office hours

Tuesday and Thursday - 12:00 - 1:30 PM

Degrees

  • B.S. Chemistry, Belgrade University, Serbia, 2001
  • Ph.D Chemistry, Georgetown University, Washington, DC 2007

Academic Appointments

  • Assistant Professor, Temple University, 2015 – present
  • Instructor, Systems & Computational Biology Department, Albert Einstein College of Medicine, New York, NY, 2012 - 2015
  • Research Fellow, Anatomy and Structural Biology Department, Albert Einstein College of Medicine, New York, NY, 2007 - 2012

Recent Publications

  • B. Bayarmagnai, L. Perrin, K. Esmaeili, B. Gligorijevic. (2018) “Invadopodia degrade ECM in the G1 phase of the cell cycle”, biorXiv [Preprint] doi.org/10.1101/412916.
  • K. Esmaeili, A. Bergman, B. Gligorijevic. (2018) “Extracellular matrix cross-linking regulates invadopodia dynamics.” Biophysical Journal, 114:1455-1466.
  • J. Soboloff, B. Gligorijevic, R. Zaidi. (2018) "STIM1 (c)AMPs up melanogenesis", EMBO Journal (2018), 37:e99047.
  • K. Esmaeili, E. Cardenas De La Hoz, AR. Cohen, B. Gligorijevic. (2018) “Contact guidance is cell cycle dependent" APL Bioengineering, 2(3):031904.
  • B. Bayarmagnai, L. Perrin., K. Esmaeili, B. Gligorijevic. (2018) “Intravital imaging of cell migration”, Methods in molecular biology, 1749:175-193.
  • F. Tonisen, L. Perrin. K van der Dries, A. Cambi, B. Gligorijevic. (2017) “EP4 receptor role in invasion of breast carcinoma” European Journal of Cell Biology, 96(2):218-226.
  • Bergman, B. Gligorijevic. (2015) “Niche Construction Game Cancer Cells Play”, in Physics of Cancer collection, European Physics Journal Plus (2015) 130:203-205.
  • Bergman, J. Condeelis, B. Gligorijevic. (2014) “Invadopodia in Context”, Cell Adhesion and Migration (2014) 8:273-279.
  • E. Genot, B. Gligorijevic (2014) “Invadosomes in their natural habitat”, European Journal of Cell Biology 93(10-12):367-79.
  • B. Gligorijevic, A. Bergman, J. Condeelis. (2014) ”Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype”, Plos Biology 12: 1-15, e1001995.

Professional Activity

Grant Reviews

  • 2018 Early Career Reviewer, NIH, NCI, Tumor Progression and Metastasis Study Section
  • 2017 Reviewer, Pennsylvania Breast Cancer Coalition Grants
  • 2017 Expert Grant Reviewer, National Science Foundation of Poland
  • 2017 Ad hoc reviewer, Study section on Cancer Structure and Metastasis, American Cancer Society  
  • 2015 Reviewer, National Science Foundation, Systems and Molecular Biology, GRF program   
  • 2015-2016 Expert Grant Reviewer, Swiss National Science Foundation
  • 2012-2013 Reviewer, AACR INNOVATOR Award in Tumor Microenvironment, Landon Foundation
  • 2009 Reviewer, National Science Foundation, ARI-R2, Chemistry Study Section

Conference proceedings

  • T. Gillin, B. Gligorijevic, K. Darvish (2017) “Characterization of transmural morphological properties in porcine thoracic descending aorta using multiphoton microscopy and image processing”, Summer Biomechanics, Bioengineering and Biotransport Conference, Abstract 1217
  • K. Esmaeili, B. Gligorijevic (2016) “Integrating live-cell fluorescent microscopy and signal processing to discover the relationship of invadopodia digging cycles with extracellular matrix crosslinking ratio, 2016 IEEE SPMB Proceedings
  • K. Esmaeili, B. Gligorijevic (2018) “Dissecting cell-cycle phase dependency of cancer cells invasiveness and migration speed”, Paper 10491-44, SPIE Microfluidics, BioMEMS, and Medical Microsystems XVI Proceedings 2018
  • Gillin T*, Darvish K, Hemmasi A., Gligorijevic B (2017), “Quantification of Porcine Aorta Proteins Orientation Using Multiphoton Fluorescent Microscopy and Image Processing” NEBEC, Biomedical Imaging & Image Processing
  • Kight E, Esmaeili K, Gligorijevic B. “An in vitro study of Metastatic Breast Cancer Cells Migration Speed vs. Their Cell Cycle Phase Using A Microfluidic Device” (2017) Annual Biomedical Research Conference for Minority Students, Cancer Biology 049-083.
  • Kight E, Gligorijevic B. (2018)  “An in vitro study of Metastatic Breast Cancer Cells Migration Speed vs. Their Cell Cycle Phase Using A Microfluidic Device” BMES

Other

  • 2016 Guest Editor, Invadosomes, European Journal of Cell Biology
  • 2015 Organizing Vice Chair, Integrative Mechano-Chemical Signaling in Invasion, Nice, France   

Research Interest

The Gligorijevic lab studies how tumor microenvironments control decision-making of tumor cells. We are currently focused on the investigation of motile tumor cells in the primary tumor with the goal of building a predictive model of tumor cell entry into blood vessels (intravasation). Towards our goal, our primary tool is intravital multiphoton microscopy in animal models, which is combined with classical molecular and cell biology, mathematical and computational modeling, cancer engineering and systems view into a “systems microscopy” approach. Results of our work will be useful in improvement of early diagnosis of metastasis and testing of novel therapeutic agents.

Funding Sources

  • NCI/NIH K99/R00, Systems microscopy of tumor cell motility in microenvironment context, 2013 - 2018
  • Charles H Revson Postdoctoral Fellowship in Biomedical Sciences Program, 2010 - 2012
  • Concept Award, Breast Cancer Research Program of Department of Defense 2008 - 2009