Biography

Peter I. Lelkes, PhD, is the Laura H. Carnell Professor and Founding Chair of the Department of Bioengineering in the College of Engineering at Temple University. Dr. Lelkes is also the Inaugural Director of the Institute for Regenerative Medicine and Engineering (TIME) at Temple University’s School of Medicine. Prior to that he was from 2000-2011 the Calhoun Chair Professor in the School of Biomedical Engineering, Science and Health Systems at Drexel University in Philadelphia.

Dr. Lelkes has received numerous honors and awards, nationally and internationally. Amongst them a Forchheimer Visiting Fellowship at the Hebrew University, Jerusalem, Honorary Professorships at the University of Applied Sciences Aachen, Germany and the Changchun Institute of Polymer Chemistry and Physics, Chinese Academy of Sciences, and a Distinguished Visiting Fellowship of the Royal Academy of Engineering at Imperial College, London, UK. In 2011 he was inducted as a Fellow of the AIMBE (American Institute for Medical and Biological Engineering) and received the 2012 Ben Franklin Key Award from IEEE, the Institute of Electrical and Electronics Engineers.

Throughout his career of 30+ years, Dr. Lelkes has received over $18 million in funding from numerous federal and private funding sources. Dr. Lelkes has organized several Keystone conferences, published more than 175 peer-reviewed papers, authored more than 50 books / book chapters and made more than 400 presentations nationally and internationally.

In his “free-time” Dr. Lelkes is an active chamber musician and likes to hike in the mountains.

Research Interests

  • Regenerative Tissue Engineering
  • Nanotechnology-Based Biomaterials
  • Soft Tissue Engineering
  • Tissue-Specific Differentiation of Embryonic & Adult Stem Cells Towards Pulmonary, Cardiac & Neuronal Lineages
  • Absorbable Bone Fixation and Regenerative Repair Technologies

Courses Taught

Number

Name

Level

BIOE 0944

Honors Bionic Human

Undergraduate

BIOE 5501

Regenerative Engineering

Graduate

Selected Publications

Recent

  • Oss-Ronen, L., Redden, R.A., & Lelkes, P.I. (2020). Enhanced Induction of Definitive Endoderm Differentiation of Mouse Embryonic Stem Cells in Simulated Microgravity. Stem Cells and Development, 29(19), pp. 1275-1284. doi: 10.1089/scd.2020.0097

  • Phelan, M.A., Kruczek, K., Wilson, J.H., Brooks, M.J., Drinnan, C.T., Regent, F., Gerstenhaber, J.A., Swaroop, A., Lelkes, P.I., & Li, T. (2020). Soy Protein Nanofiber Scaffolds for Uniform Maturation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium. Tissue Engineering - Part C: Methods, 26(8), pp. 433-446. doi: 10.1089/ten.tec.2020.0072

  • Lazarovici, P., Marcinkiewicz, C., & Lelkes, P.I. (2020). Cell-based adhesion assays for isolation of snake venom’s integrin antagonists., 2068, pp. 205-223. doi: 10.1007/978-1-4939-9845-6_11

  • Goulart, E., Caires-Junior, L.C.D.e., Telles-Silva, K.A., Araujo, B., Rocco, S.A., Sforca, M., Sousa, I.L.D.e., Kobayashi, G.S., Musso, C.M., Assoni, A.F., Oliveira, D., Caldini, E., Raia, S., Lelkes, P.I., & Zatz, M. (2020). 3D bioprinting of liver spheroids derived from human induced pluripotent stem cells sustain liver function and viability in vitro. Biofabrication, 12(1). doi: 10.1088/1758-5090/ab4a30

  • Feuerstein, G.Z., Mansfield, M.A., Lelkes, P.I., Alesci, S., Marcinkiewicz, C., Butlin, N., & Sternberg, M. (2020). The Use of Near-Infrared Light-Emitting Fluorescent Nanodiamond Particles to Detect Ebola Virus Glycoprotein: Technology Development and Proof of Principle. International Journal of Nanomedicine, 15, pp. 7583-7599. doi: 10.2147/IJN.S261952

  • Marcinkiewicz, C., Lelkes, P.I., Sternberg, M., & Feuerstein, G.Z. (2020). Effects of fluorescent diamond particles fdp-nv-800nm on essential biochemical functions of primary human umbilical vein cells and human hepatic cell line, hepg-2 in vitro (Part vi): Acute biocompatibility studies. Nanotechnology, Science and Applications, 13, pp. 103-118. doi: 10.2147/NSA.S268107

  • Du, Y., Montoya, C., Orrego, S., Wei, X., Ling, J., Lelkes, P.I., & Yang, M. (2019). Topographic cues of a novel bilayered scaffold modulate dental pulp stem cells differentiation by regulating YAP signalling through cytoskeleton adjustments. Cell Proliferation, 52(6). doi: 10.1111/cpr.12676

  • Goulart, E., Caires-Junior, L.C.D.e., Telles-Silva, K.A., Araujo, B., Kobayashi, G.S., Musso, C.M., Assoni, A.F., Oliveira, D., Caldini, E., Gerstenhaber, J.A., Raia, S., Lelkes, P.I., & Zatz, M. (2019). Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-ß. Stem Cell Research and Therapy, 10(1). doi: 10.1186/s13287-019-1367-x

  • Malik, R., Luong, T., Cao, X., Han, B., Shah, N., Franco-Barraza, J., Han, L., Shenoy, V.B., Lelkes, P.I., & Cukierman, E. (2019). Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2. Matrix Biology, 81, pp. 50-69. doi: 10.1016/j.matbio.2018.11.001

  • Phelan, M.A., Gianforcaro, A.L., Gerstenhaber, J.A., & Lelkes, P.I. (2019). An Air Bubble-Isolating Rotating Wall Vessel Bioreactor for Improved Spheroid/Organoid Formation. Tissue Engineering - Part C: Methods, 25(8), pp. 479-488. doi: 10.1089/ten.tec.2019.0088

  • Phelan, M., Lelkes, P., & Swaroop, A. (2019). Customized rotating wall vessel bioreactors produce improved retinal organoids with reduced operational costs and less frequent experimental failure. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9). Retrieved from http://gateway.webofknowledge.com/

  • Lazarovici, P., Marcinkiewicz, C., & Lelkes, P.I. (2019). From snake venom’s disintegrins and C-type lectins to anti-platelet drugs. Toxins, 11(5). doi: 10.3390/toxins11050303

  • Gangolli, R.A., Devlin, S.M., Gerstenhaber, J.A., Lelkes, P.I., & Yang, M. (2019). A Bilayered Poly (Lactic-Co-Glycolic Acid) Scaffold Provides Differential Cues for the Differentiation of Dental Pulp Stem Cells. Tissue Engineering - Part A, 25(3-4), pp. 224-233. doi: 10.1089/ten.tea.2018.0041

  • Novosel, E., Borchers, K., Kluger, P.J., Mantalaris, A., Matheis, G., Pistolesi, M., Schneider, J., Wenz, A., & Lelkes, P.I. (2019). New approaches to respiratory assist: Bioengineering an ambulatory, miniaturized bioartificial lung. ASAIO Journal, 65(5), pp. 422-429. doi: 10.1097/MAT.0000000000000841

  • Barone, F.C., Marcinkiewicz, C., Li, J., Feng, Y., Sternberg, M., Lelkes, P.I., Rosenbaum-Halevi, D., Gerstenhaber, J.A., & Feuerstein, G.Z. (2019). Long-term biocompatibility of fluorescent diamonds-(NV)-Z~800 nm in rats: Survival, morbidity, histopathology, particle distribution and excretion studies (part IV). International Journal of Nanomedicine, 14, pp. 1163-1175. doi: 10.2147/IJN.S189048

  • Gerstenhaber, J.A., Marcinkiewicz, C., Barone, F.C., Sternberg, M., D’Andrea, M.R., Lelkes, P.I., & Feuerstein, G.Z. (2019). Biocompatibility studies of fluorescent diamond particles-(Nv)~800nm (part v): In vitro kinetics and in vivo localization in rat liver following long-term exposure. International Journal of Nanomedicine, 14, pp. 6451-6464. doi: 10.2147/IJN.S209663

  • Phelan, M.A., Lelkes, P.I., & Swaroop, A. (2018). Mini and customized low-cost bioreactors for optimized high-throughput generation of tissue organoids. Stem Cell Investigation, 5(October). doi: 10.21037/sci.2018.09.06

  • Timnak, A., Gerstenhaber, J.A., Dong, K., Har-El, Y.E., & Lelkes, P.I. (2018). Gradient porous fibrous scaffolds: A novel approach to improving cell penetration in electrospun scaffolds. Biomedical Materials (Bristol), 13(6). doi: 10.1088/1748-605X/aadbbe

  • Barone, F.C., Gerstenhaber, J.A., Marcinkiewicz, C., Li, J., Lelkes, P.I., Sternberg, M., & Feuerstein, G.Z. (2018). Imaging Intra-Carotid Thrombosis Using Near InfraRed Fluorescent-NanoDiamond Particles Bio-engineered With the Disintegrin Bitistatin. STROKE, 49. Retrieved from http://gateway.webofknowledge.com/

  • Barone, F.C., Gerstenhaber, J.A., Marcinkiewicz, C., Li, J., Lelkes, P.I., Sternberg, M., & Feuerstein, G.Z. (2018). Imaging Intra-Carotid Thrombosis Using Near InfraRed Fluorescent-NanoDiamond Particles Bio-engineered With the Disintegrin Bitistatin. STROKE, 49. Retrieved from http://gateway.webofknowledge.com/

  • Barone, F.C., Marcinkiewicz, C., Li, J., Sternberg, M., Lelkes, P.I., Dikin, D.A., Bergold, P.J., Gerstenhaber, J.A., & Feuerstein, G. (2018). Pilot study on biocompatibility of fluorescent nanodiamond-(NV)-Z~800 particles in rats: Safety, pharmacokinetics, and bio-distribution (Part III). International Journal of Nanomedicine, 13, pp. 5449-5468. doi: 10.2147/IJN.S171117

  • Lelkes, P.I. (2018). Methodological aspects dealing with stability measurements of liposomes in vitro using the carboxyfluoresceinassay. In Liposome Technology: Volume III: Targeted Drug Delivery and Biological Interaction (pp. 225-246). doi: 10.1201/9781351074124

  • Lazarovici, P., Lahiani, A., Gincberg, G., Haham, D., Fluksman, A., Benny, O., Marcinkiewicz, C., & Lelkes, P.I. (2018). Nerve growth factor-induced angiogenesis: 1. Endothelial cell tube formation assay. In Methods in Molecular Biology, 1727 (pp. 239-250). doi: 10.1007/978-1-4939-7571-6_18

  • Lazarovici, P., Lahiani, A., Gincberg, G., Haham, D., Marcinkiewicz, C., & Lelkes, P.I. (2018). Nerve growth factor-induced angiogenesis: 2. The quail chorioallantoic membrane assay. In Methods in Molecular Biology, 1727 (pp. 251-259). doi: 10.1007/978-1-4939-7571-6_19

  • Senel-Ayaz, H.G., Har-El, Y.E., Ayaz, H., & Lelkes, P.I. (2018). Textile technologies for 3D scaffold engineering. In Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications (pp. 175-201). doi: 10.1016/B978-0-08-100979-6.00008-2

  • Lelkes, P.I. (2018). Methodological aspects dealing with stability measurements of liposomes in vitro using the carboxyfluoresceinassay. In Liposome Technology Volume III: Targeted Drug Delivery and Biological Interaction (pp. 225-246). doi: 10.1201/9781351074117

  • Senel-Ayaz, H.G., Har-El, Y., Ayaz, H., & Lelkes, P.I. (2018). 8 Textile technologies for 3D scaffold engineering. In Functional 3D Tissue Engineering Scaffolds (pp. 175-201). doi: 10.1016/b978-0-08-100979-6.00008-2

  • Timnak, A., Har-el, Y., & Lelkes, P.I. (2017). Macrophage Infiltration into Macro-porous Electrospun Scaffolds Initiates a Reparative Inflammatory Response. TISSUE ENGINEERING PART A, 23, pp. S41-S41. Retrieved from http://gateway.webofknowledge.com/

  • Gerstenhaber, J.A., Barone, F.C., Marcinkiewicz, C., Li, J., Shiloh, A.O., Sternberg, M., Lelkes, P.I., & Feuerstein, G. (2017). Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II). International Journal of Nanomedicine, 12, pp. 8471-8482. doi: 10.2147/IJN.S146946

  • Marcinkiewicz, C., Gerstenhaber, J.A., Sternberg, M., Lelkes, P.I., & Feuerstein, G. (2017). Bitistatin-functionalized fluorescent nanodiamond particles specifically bind to purified human platelet integrin receptor aiibß3 and activated platelets. International Journal of Nanomedicine, 12, pp. 3711-3720. doi: 10.2147/IJN.S134128

  • Kischkel, S., Bergt, S., Brock, B., Grönheim, J.V., Herbst, A., Epping, M.J., Matheis, G., Novosel, E., Schneider, J., Warnke, P., Podbielski, A., Roesner, J.P., Lelkes, P.I., & Vollmar, B. (2017). In Vivo Testing of Extracorporeal Membrane Ventilators: ILA-Activve Versus Prototype I-Lung. ASAIO Journal, 63(2), pp. 185-192. doi: 10.1097/MAT.0000000000000465

  • Devlin, S.M., Gangolli, R.A., Spangenberg, N., Batish, R., Hagaman, D., Ji, H., & Lelkes, P.I. (2016). Improving Degradable Biomaterials for Orthopedic Fixation Devices. TISSUE ENGINEERING PART A, 22, pp. S147-S147. Retrieved from http://gateway.webofknowledge.com/

  • Gangolli, R.A., Devlin, S.M., Ailavajhala, R., Hanifi, A., Pleshko, N., Lelkes, P.I., & Yang, M. (2016). Biomimetic Scaffold to Regenerate the Pulp Dentin Complex. TISSUE ENGINEERING PART A, 22, pp. S72-S72. Retrieved from http://gateway.webofknowledge.com/

  • Wass, B.M., Lelkes, P.I., Stabler, C.T., & Garcia, R. (2016). Model of Microvascular Pulmonary Inflammation Modulated by Extracellular Matrix Mechanical Properties. TISSUE ENGINEERING PART A, 22, pp. S66-S66. Retrieved from http://gateway.webofknowledge.com/

  • Palukuru, U.P., Hanifi, A., McGoverin, C.M., Devlin, S., Lelkes, P.I., & Pleshko, N. (2016). Near infrared spectroscopic imaging assessment of cartilage composition: Validation with mid infrared imaging spectroscopy. Analytica Chimica Acta, 926, pp. 79-87. doi: 10.1016/j.aca.2016.04.031

  • Stabler, C.T., Caires, L.C., Mondrinos, M.J., Marcinkiewicz, C., Lazarovici, P., Wolfson, M.R., & Lelkes, P.I. (2016). Enhanced Re-Endothelialization of Decellularized Rat Lungs. Tissue Engineering - Part C: Methods, 22(5), pp. 439-450. doi: 10.1089/ten.tec.2016.0012