Biography

Dr. Nancy Pleshko is a Professor in the Department of Bioengineering at Temple University, Philadelphia, PA. Dr. Pleshko is recognized for her research on assessment of tissues at the molecular, cellular, and structural level through application of state-of-the-art vibrational spectroscopy. She has substantial expertise in basic and translational research in connective tissue pathophysiology and orthopedics, including osteoporosis and other bone pathologies, and osteoarthritis and cartilage repair. She has over 90 publications, and has received over $5 million in federal funding.

Research Interests

  • Molecular Imaging of Tissues & Cells
  • Spectroscopic Analysis Techniques for Cartilage and Bone Pathologies
  • Tissue Engineering
  • Contribution of Molecular Alterations in Connective Tissue on Mechanical Behavior
  • MicroCT & Magnetic Resonance Imaging of Connective Tissues

Courses Taught

Number

Name

Level

ENGG 3385

Diamond Peer Teachers - Internship I

Undergraduate

BIOE 0856

Ethical Issues in Biomedical Science, Engineering and Technology

Undergraduate

BIOE 3001

Research Design and Methods in Bioengineering

Undergraduate

Selected Publications

  • Miguez, P.A., Tuin, S.A., Robinson, A.G., Belcher, J., Jongwattanapisan, P., Perley, K., Gon¿alves, V., Hanifi, A., Pleshko, N., & Barton, E.R. (2021). Hesperidin promotes osteogenesis and modulates collagen matrix organization and mineralization in vitro and in vivo. International Journal of Molecular Sciences, 22(6), pp. 1-13. doi: 10.3390/ijms22063223

  • Sanden, K.W., Böcker, U., Ofstad, R., Pedersen, M.E., Høst, V., Afseth, N.K., Rønning, S.B., & Pleshko, N. (2021). Characterization of collagen structure in normal, wooden breast and spaghetti meat chicken fillets by ftir microspectroscopy and histology. Foods, 10(3). doi: 10.3390/foods10030548

  • Jones, B.C., Jia, S., Lee, H., Feng, A., Shetye, S.S., Batzdorf, A., Shapira, N., Noël, P.B., Pleshko, N., & Rajapakse, C.S. (2021). MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora. Bone, 143. doi: 10.1016/j.bone.2020.115774

  • Afara, I.O., Shaikh, R., Nippolainen, E., Querido, W., Torniainen, J., Sarin, J.K., Kandel, S., Pleshko, N., & Töyräs, J. (2021). Characterization of connective tissues using near-infrared spectroscopy and imaging. Nature Protocols, 16(2), pp. 1297-1329. doi: 10.1038/s41596-020-00468-z

  • Querido, W., Kandel, S., & Pleshko, N. (2021). Applications of vibrational spectroscopy for analysis of connective tissues. Molecules, 26(4). doi: 10.3390/molecules26040922

  • Chirman, D. & Pleshko, N. (2021). Characterization of bacterial biofilm infections with Fourier transform infrared spectroscopy: a review. Applied Spectroscopy Reviews, 56(8-10), pp. 673-701. doi: 10.1080/05704928.2020.1864392

  • Ailavajhala, R., Querido, W., Rajapakse, C.S., & Pleshko, N. (2020). Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water. Analyst, 145(10), pp. 3713-3724. doi: 10.1039/c9an02491c

  • Shanas, N., Querido, W., Dumont, A., Yonko, E., Carter, E., Ok, J., Karchner, J.P., Barbe, M.F., Ali, S., Patil, C., Raggio, C., & Pleshko, N. (2020). Clinical application of near infrared fiber optic spectroscopy for noninvasive bone assessment. Journal of Biophotonics, 13(4). doi: 10.1002/jbio.201960172

  • Kandel, S., Querido, W., Falcon, J.M., Reiners, D.J., & Pleshko, N. (2020). Approaches for in situ monitoring of matrix development in hydrogel-based engineered cartilage. Tissue Engineering - Part C: Methods, 26(4), pp. 225-238. doi: 10.1089/ten.tec.2020.0014

  • Querido, W., Shanas, N., Bookbinder, S., Oliveira-Nunes, M.C., Krynska, B., & Pleshko, N. (2020). Fourier transform infrared spectroscopy of developing bone mineral: From amorphous precursor to mature crystal. Analyst, 145(3), pp. 764-776. doi: 10.1039/c9an01588d

  • Falcon, J.M., Chirman, D., Veneziale, A., Morman, J., Bolten, K., Kandel, S., Querido, W., Freeman, T., & Pleshko, N. (2020). DMOG Negatively Impacts Tissue Engineered Cartilage Development. Cartilage. doi: 10.1177/1947603520967060

  • Ailavajhala, R., Oswald, J., Rajapakse, C.S., & Pleshko, N. (2019). Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water. Scientific Reports, 9(1). doi: 10.1038/s41598-019-45897-3

  • Hong, A.L., Ispiryan, M., Padalkar, M.V., Jones, B.C., Batzdorf, A.S., Shetye, S.S., Pleshko, N., & Rajapakse, C.S. (2019). MRI-derived bone porosity index correlates to bone composition and mechanical stiffness. Bone Reports, 11. doi: 10.1016/j.bonr.2019.100213

  • Karchner, J.P., Yousefi, F., Bitman, S.R., Darvish, K., & Pleshko, N. (2019). Non-Destructive Spectroscopic Assessment of High and Low Weight Bearing Articular Cartilage Correlates with Mechanical Properties. Cartilage, 10(4), pp. 480-490. doi: 10.1177/1947603518764269

  • Karchner, J.P., Querido, W., Kandel, S., & Pleshko, N. (2019). Spatial correlation of native and engineered cartilage components at micron resolution. Annals of the New York Academy of Sciences, 1442(1), pp. 104-117. doi: 10.1111/nyas.13934

  • Tint, D., Stabler, C.T., Hanifi, A., Yousefi, F., Linkov, G., Hy, K., Soliman, A., & Pleshko, N. (2019). Spectroscopic Analysis of Human Tracheal Tissue during Decellularization. Otolaryngology - Head and Neck Surgery (United States), 160(2), pp. 302-309. doi: 10.1177/0194599818806271

  • Jongwattanapisan, P., Terajima, M., Miguez, P.A., Querido, W., Nagaoka, H., Sumida, N., Gurysh, E.G., Ainslie, K.M., Pleshko, N., Perera, L., & Yamauchi, M. (2018). Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function. Scientific Reports, 8(1). doi: 10.1038/s41598-018-25279-x

  • Querido, W., Ailavajhala, R., Padalkar, M., & Pleshko, N. (2018). Validated Approaches for Quantification of Bone Mineral Crystallinity Using Transmission Fourier Transform Infrared (FT-IR), Attenuated Total Reflection (ATR) FT-IR, and Raman Spectroscopy. Applied Spectroscopy, 72(11), pp. 1581-1593. doi: 10.1177/0003702818789165

  • Wischmann, J., Lenze, F., Thiel, A., Bookbinder, S., Querido, W., Schmidt, O., Burgkart, R., Eisenhart-Rothe, R.v., Richter, G., Pleshko, N., & Mayer-Kuckuk, P. (2018). Matrix mineralization controls gene expression in osteoblastic cells. Experimental Cell Research, 372(1), pp. 25-34. doi: 10.1016/j.yexcr.2018.09.005

  • Yousefi, F., Kandel, S., & Pleshko, N. (2018). Infrared Spectroscopic Quantification of Methacrylation of Hyaluronic Acid: A Scaffold for Tissue Engineering Applications. Applied Spectroscopy, 72(10), pp. 1455-1466. doi: 10.1177/0003702818785353

  • Choi, H., Tessier, S., Silagi, E.S., Kyada, R., Yousefi, F., Pleshko, N., Shapiro, I.M., & Risbud, M.V. (2018). A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biology, 70, pp. 102-122. doi: 10.1016/j.matbio.2018.03.019

  • Linkov, G., Hanifi, A., Yousefi, F., Tint, D., Bolla, S., Marchetti, N., Soliman, A., & Pleshko, N. (2018). Compositional Assessment of Human Tracheal Cartilage by Infrared Spectroscopy. Otolaryngology - Head and Neck Surgery (United States), 158(4), pp. 688-694. doi: 10.1177/0194599817752310

  • Yousefi, F., Kim, M., Nahri, S.Y., Mauck, R.L., & Pleshko, N. (2018). Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs. Tissue Engineering - Part A, 24(1-2), pp. 106-116. doi: 10.1089/ten.tea.2017.0035

  • Querido, W., Falcon, J.M., Kandel, S., & Pleshko, N. (2017). Vibrational spectroscopy and imaging: Applications for tissue engineering. Analyst, 142(21), pp. 4005-4017. doi: 10.1039/c7an01055a

  • Qu, D., Subramony, S.D., Boskey, A.L., Pleshko, N., Doty, S.B., & Lu, H.H. (2017). Compositional mapping of the mature anterior cruciate ligament-to-bone insertion. Journal of Orthopaedic Research, 35(11), pp. 2513-2523. doi: 10.1002/jor.23539

  • Rajapakse, C.S., Padalkar, M.V., Yang, H.J., Ispiryan, M., & Pleshko, N. (2017). Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements. Bone, 103, pp. 116-124. doi: 10.1016/j.bone.2017.06.015

  • Doty, S.B., Bostrom, M.P., Bockman, R.S., Meulen, M.C.H.v.d., & Pleshko, N. (2017). Adele Ludin Boskey, PhD IN MEMORIAM. JOURNAL of BONE and MINERAL RESEARCH, 32(8), pp. 1597-1598. doi: 10.1002/jbmr.3187

  • Hanifi, A., Palukuru, U., McGoverin, C., Shockley, M., Frank, E., Grodzinsky, A., Spencer, R.G., & Pleshko, N. (2017). Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties. Analyst, 142(8), pp. 1320-1332. doi: 10.1039/c6an02167k

  • Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. Cardiovascular Engineering and Technology, 8(1), pp. 70-80. doi: 10.1007/s13239-016-0289-3

  • Spencer, R.G., Cortese, B.D., Lukas, V.A., & Pleshko, N. (2017). Point Estimates of Test Sensitivity and Specificity from Sample Means and Variances. American Statistician, 71(1), pp. 81-87. doi: 10.1080/00031305.2016.1239589

  • Marcott, C., Padalkar, M., & Pleshko, N. (2017). 3.23 Infrared and raman microscopy and imaging of biomaterials at the micro and nano scale. In Comprehensive Biomaterials II (pp. 498-518). doi: 10.1016/B978-0-12-803581-8.10183-3

  • Wolfson, M.R., Pleshko, N., Darvish, K.K., Baker, S.T., Wu, J., Kyada, R., Nelson, C., Fukuda, S., Enkhbaatar, P., Florova, G., Komissarov, A.A., Idell, S., & Shaffer, T.H. (2017). Differential Impact Of Fibrinolysins On Airway Cast Composition And Mechanical Properties Assessed By A Novel Infrared Imaging And Microindentation Approach. AMERICAN JOURNAL of RESPIRATORY and CRITICAL CARE MEDICINE, 195. Retrieved from http://gateway.webofknowledge.com/

  • Bozkurt, O., Bilgin, M.D., Evis, Z., Pleshko, N., & Severcan, F. (2016). Early Alterations in Bone Characteristics of Type i Diabetic Rat Femur: A Fourier Transform Infrared (FT-IR) Imaging Study. Applied Spectroscopy, 70(12), pp. 2005-2015. doi: 10.1177/0003702816671059

  • Gangolli, R.A., Devlin, S.M., Ailavajhala, R., Hanifi, A., Pleshko, N., Lelkes, P.I., & Yang, M. (2016). Biomimetic Scaffold to Regenerate the Pulp Dentin Complex. TISSUE ENGINEERING PART A, 22, pp. S72-S72. Retrieved from http://gateway.webofknowledge.com/

  • Raggio, C.L., Pleshko, N., & Boskey, A.L. (2016). The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data. Journal of Bone and Mineral Research, 31(11), p. 2065. doi: 10.1002/jbmr.2976

  • Eisenhauer, P., Chernets, N., Song, Y., Dobrynin, D., Pleshko, N., Steinbeck, M.J., & Freeman, T.A. (2016). Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation. Journal of Tissue Engineering and Regenerative Medicine, 10(9), pp. 772-782. doi: 10.1002/term.2224

  • Palukuru, U.P., Hanifi, A., McGoverin, C.M., Devlin, S., Lelkes, P.I., & Pleshko, N. (2016). Near infrared spectroscopic imaging assessment of cartilage composition: Validation with mid infrared imaging spectroscopy. Analytica Chimica Acta, 926, pp. 79-87. doi: 10.1016/j.aca.2016.04.031

  • Ashinsky, B.G., Fishbein, K.W., Carter, E.M., Lin, P.C., Pleshko, N., Raggio, C.L., & Spencer, R.G. (2016). Multiparametric classification of skin from osteogenesis imperfecta patients and controls by quantitative magnetic resonance microimaging. PLoS ONE, 11(7). doi: 10.1371/journal.pone.0157891

  • McGoverin, C.M., Hanifi, A., Palukuru, U.P., Yousefi, F., Glenn, P., Shockley, M., Spencer, R.G., & Pleshko, N. (2016). Nondestructive Assessment of Engineered Cartilage Composition by Near Infrared Spectroscopy. Annals of Biomedical Engineering, 44(3), pp. 680-692. doi: 10.1007/s10439-015-1536-8

  • Cheng, H.A., Drinnan, C.T., Pleshko, N., & Fisher, O.Z. (2015). Pseudotannins self-assembled into antioxidant complexes. Soft Matter, 11(39), pp. 7783-7791. doi: 10.1039/c5sm01224d

  • Boskey, A.L., Marino, J., Spevak, L., Pleshko, N., Doty, S., Carter, E.M., & Raggio, C.L. (2015). Are Changes in Composition in Response to Treatment of a Mouse Model of Osteogenesis Imperfecta Sex-dependent? Clinical Orthopaedics and Related Research, 473(8), pp. 2587-2598. doi: 10.1007/s11999-015-4268-z

  • O’Brien, M.P., Penmatsa, M., Palukuru, U., West, P., Yang, X., Bostrom, M., Freeman, T., & Pleshko, N. (2015). Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy. Cartilage, 6(3), pp. 174-184. doi: 10.1177/1947603515572874

  • Padalkar, M.V. & Pleshko, N. (2015). Wavelength-dependent penetration depth of near infrared radiation into cartilage. Analyst, 140(7), pp. 2093-2100. doi: 10.1039/c4an01987c

  • Gollwitzer, H., Yang, X., Spevak, L., Lukashova, L., Nocon, A., Fields, K., Pleshko, N., Courtland, H.W., Bostrom, M.P., & Boskey, A.L. (2015). Fourier transform infrared spectroscopic imaging of fracture healing in the normal mouse. Journal of Spectroscopy, 2015. doi: 10.1155/2015/659473

  • Hemmasizadeh, A., Tsamis, A., Cheheltani, R., Assari, S., D'Amore, A., Autieri, M., Kiani, M.F., Pleshko, N., Wagner, W.R., Watkins, S.C., Vorp, D., & Darvish, K. (2015). Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. Journal of the Mechanical Behavior of Biomedical Materials, 47, pp. 12-20. doi: 10.1016/j.jmbbm.2015.03.004

  • Khanarian, N.T., Boushell, M.K., Spalazzi, J.P., Pleshko, N., Boskey, A.L., & Lu, H.H. (2014). FTIR-I compositional mapping of the cartilage-to-bone interface as a function of tissue region and age. Journal of Bone and Mineral Research, 29(12), pp. 2643-2652. doi: 10.1002/jbmr.2284

  • McGoverin, C.M., Lewis, K., Yang, X., Bostrom, M., & Pleshko, N. (2014). The contribution of bone and cartilage to the near-infrared spectrum of osteochondral tissue. Applied Spectroscopy, 68(10), pp. 1168-1175. doi: 10.1366/13-07327

  • Palukuru, U.P., McGoverin, C.M., & Pleshko, N. (2014). Assessment of hyaline cartilage matrix composition using near infrared spectroscopy. Matrix Biology. doi: 10.1016/j.matbio.2014.07.007

  • Terajima, M., Perdivara, I., Sricholpech, M., Deguchi, Y., Pleshko, N., Tomer, K.B., & Yamauchi, M. (2014). Glycosylation and cross-linking in bone type I collagen. Journal of Biological Chemistry, 289(33), pp. 22636-22647. doi: 10.1074/jbc.M113.528513

  • Cheheltani, R., McGoverin, C.M., Rao, J., Vorp, D.A., Kiani, M.F., & Pleshko, N. (2014). Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta. Analyst, 139(12), pp. 3039-3047. doi: 10.1039/c3an02371k

  • Johnson, C.M., Pleshko, N., Achary, M., & Suri, R. (2014). Rapid and sensitive screening of 17ß-estradiol estrogenicity using fourier transform infrared imaging spectroscopy (FT-IRIS). Environmental Science and Technology, 48(8), pp. 4581-4587. doi: 10.1021/es5000676

  • Caccese, N., Palukuru, U., Thakkar, P., McGoverin, C., Pleshko, N., Cheng, C., Solorio, L., Correa, D., Philips, L., McMillan, A., & Alsberg, E. (2014). FTIR imaging analysis of bioactive microsphere incorporated stem cell sheets for osteochondral defect repair. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2014-December. doi: 10.1109/NEBEC.2014.6972745

  • Padalkar, M., McGoverin, C., Onigbanjo, Q., Spencer, R., Barbash, S., Kropf, E., & Pleshko, N. (2014). Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8926. doi: 10.1117/12.2047473

  • Sahu, A., Saleheen, F., Oleksyuk, V., McGoverin, C., Pleshko, N., Torbati, A., Picone, J., Sorenmo, K., & Won, C.H. (2014). Characterization of mammary tumors using noninvasive tactile and hyperspectral sensors. IEEE Sensors Journal, 14(10), pp. 3337-3344. doi: 10.1109/JSEN.2014.2323215

  • Barbe, M.F., Adiga, R., Gordiienko, O., Pleshko, N., Selzer, M.E., & Krynska, B. (2014). Micro-computed tomography assessment of vertebral column defects in retinoic acid-Induced rat model of myelomeningocele. Birth Defects Research Part a - Clinical and Molecular Teratology, 100(6), pp. 453-462. doi: 10.1002/bdra.23254

  • Cheheltani, R., Rao, J., Vorp, D.A., Pleshko, N., & Kiani, M.F. (2013). Prediction of Elastin Degradation in Aorta Using a Novel Infrared Spectroscopic Methodology. CIRCULATION, 128(22). Retrieved from http://gateway.webofknowledge.com/

  • Cheheltani, R., McGoverin, C.M., Kiani, M., & Pleshko, N. (2013). Infrared spectroscopy to measure collagen and elastin in aorta using multivariate analysis. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 13-14. doi: 10.1109/NEBEC.2013.103

  • Hemmasizadeh, A., Cheheltani, R., Assari, S., Pleshko, N., & Darvish, K. (2013). Spatial variation in aorta composition and correlation with mechanical properties. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 94-95. doi: 10.1109/NEBEC.2013.140

  • Padalkar, M., McGoverin, C., Pleshko, N., Barbash, S., & Kropf, E. (2013). Near infrared spectroscopy differentiates ligament and tendon composition. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 66-67. doi: 10.1109/NEBEC.2013.121

  • Palukuru, U., Shockley, M., McGoverin, C., Glenn, P., Pleshko, N., Spencer, R., Frank, E., & Grodzinsky, A. (2013). Assessment of changes in engineered cartilage using infrared spectroscopy and mechanical analysis. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 86-87. doi: 10.1109/NEBEC.2013.54

  • Shockley, M., McGoverin, C., Palukuru, U., Glenn, P., Pleshko, N., & Spencer, R. (2013). Near infrared spectroscopy as a method for non-destructive monitoring of engineered cartilage growth. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 51-52. doi: 10.1109/NEBEC.2013.119

  • Padalkar, M.V., Spencer, R.G., & Pleshko, N. (2013). Near infrared spectroscopic evaluation of water in hyaline cartilage. Annals of Biomedical Engineering, 41(11), pp. 2426-2436. doi: 10.1007/s10439-013-0844-0

  • Spalazzi, J.P., Boskey, A.L., Pleshko, N., & Lu, H.H. (2013). Quantitative Mapping of Matrix Content and Distribution across the Ligament-to-Bone Insertion. PLoS ONE, 8(9). doi: 10.1371/journal.pone.0074349

  • Sahu, A., Mcgoverin, C., Pleshko, N., Sorenmo, K., & Won, C.H. (2013). Hyperspectral imaging to discern malignant and benign canine mammary tumors. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8719. doi: 10.1117/12.2015836

  • Spencer, R.G. & Pleshko, N. (2013). How do statistical differences in matrixsensitive magnetic resonance outcomes translate into clinical assignment rules? Journal of the American Academy of Orthopaedic Surgeons, 21(7), pp. 438-439. doi: 10.5435/JAAOS-21-07-438

  • Perdivara, I., Perera, L., Sricholpech, M., Terajima, M., Pleshko, N., Yamauchi, M., & Tomer, K.B. (2013). Unusual fragmentation pathways in collagen glycopeptides. Journal of the American Society for Mass Spectrometry, 24(7), pp. 1072-1081. doi: 10.1007/s13361-013-0624-y

  • Hanifi, A., McGoverin, C., Ou, Y.T., Safadi, F., Spencer, R.G., & Pleshko, N. (2013). Differences in infrared spectroscopic data of connective tissues in transflectance and transmittance modes. Analytica Chimica Acta, 779, pp. 41-49. doi: 10.1016/j.aca.2013.03.053

  • Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier Transform Infrared Imaging and Infrared Fiber Optic Probe Spectroscopy Identify Collagen Type in Connective Tissues. PLoS ONE, 8(5). doi: 10.1371/journal.pone.0064822

  • Marino, J., Pleshko, N., Doty, S., Carter, E., Boskey, A., & Raggio, C. (2013). Switching from Alendronate to RANKL Blockade alters Bone Properties after 14 Weeks of Therapy in the oim/oim Mouse. JOURNAL of BONE and MINERAL RESEARCH, 28. Retrieved from http://gateway.webofknowledge.com/

  • Hanifi, A., Bi, X., Yang, X., Kavukcuoglu, B., Lin, P.C., Dicarlo, E., Spencer, R.G., Bostrom, M., & Pleshko, N. (2012). Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading. American Journal of Sports Medicine, 40(12), pp. 2853-2861. doi: 10.1177/0363546512462009

  • Bargman, R., Posham, R., Boskey, A., Carter, E., Dicarlo, E., Verdelis, K., Raggio, C., & Pleshko, N. (2012). High-and low-dose OPG-Fc cause osteopetrosis-like changes in infant mice. Pediatric Research, 72(5), pp. 495-501. doi: 10.1038/pr.2012.118

  • Hanifi, A., Richardson, J.B., Kuiper, J.H., Roberts, S., & Pleshko, N. (2012). Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis and Cartilage, 20(9), pp. 988-996. doi: 10.1016/j.joca.2012.05.007

  • Terajima, M., Damle, S., Penmatsa, M., West, P., Bostrom, M., Hidaka, C., Yamauchi, M., & Pleshko, N. (2012). Temporal Changes in Collagen Cross-Links in Spontaneous Articular Cartilage Repair. Cartilage, 3(3), pp. 278-287. doi: 10.1177/1947603512437736

  • Kim, M., Erickson, I.E., Choudhury, M., Pleshko, N., & Mauck, R.L. (2012). Transient exposure to TGF-ß3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels. Journal of the Mechanical Behavior of Biomedical Materials, 11, pp. 92-101. doi: 10.1016/j.jmbbm.2012.03.006

  • Cheheltani, R., Wang, B., Sabri, A., Pleshko, N., & Kiani, M. (2012). Fourier transform infrared imaging spectroscopy of collagen deposition after myocardial infarction. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 305-306. doi: 10.1109/NEBC.2012.6207086

  • Johnson, C.M., Pleshko, N., Achary, M., & Suri, R.P. (2012). Development of a Fourier transform infrared imaging spectroscopic assay for screening estrogenic contaminants. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 57-58. doi: 10.1109/NEBC.2012.6206960

  • O'Brien, M.P., Penmatsa, M., Palukuru, U., West, P., Yang, X., Bostrom, M., Freeman, T., & Pleshko, N. (2012). Comparison of histological grading to Fourier transform infrared imaging analysis of cartilage repair tissue. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 372-373. doi: 10.1109/NEBC.2012.6207119

  • Padalkar, M., Spencer, R., & Pleshko, N. (2012). Near infrared spectroscopic evaluation of water in hyaline cartilage. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 370-371. doi: 10.1109/NEBC.2012.6207118

  • Ou, Y., Belcher, J.Y., Yingling, V.R., Safadi, F., & Pleshko, N. (2012). Compositional and mechanical properties of long bones of osteoactivin mutant mice. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 436-437. doi: 10.1109/NEBC.2012.6206928

  • Hanifi, A., Terajima, M., Yamauchi, M., & Pleshko, N. (2012). Comparison of spectroscopic and biochemical determination of collagen crosslinks in cartilage. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 41-42. doi: 10.1109/NEBC.2012.6206952

  • Kavukcuoglu, N.B., Li, Q., Pleshko, N., & Uitto, J. (2012). Connective tissue mineralization in Abcc6 -/- mice, a model for pseudoxanthoma elasticum. Matrix Biology, 31(4), pp. 246-252. doi: 10.1016/j.matbio.2012.02.004

  • Reiter, D.A., Irrechukwu, O., Lin, P.C., Moghadam, S., Thaer, S.V., Pleshko, N., & Spencer, R.G. (2012). Improved MR-based characterization of engineered cartilage using multiexponential T 2 relaxation and multivariate analysis. NMR in Biomedicine, 25(3), pp. 476-488. doi: 10.1002/nbm.1804

  • Pleshko, N., Grande, D.A., & Myers, K.R. (2012). On the horizon from the ORS. Journal of the American Academy of Orthopaedic Surgeons, 20(1), pp. 60-62. doi: 10.5435/JAAOS-20-01-060

  • Bargman, R., Posham, R., Boskey, A.L., Dicarlo, E., Raggio, C., & Pleshko, N. (2012). Comparable outcomes in fracture reduction and bone properties with RANKL inhibition and alendronate treatment in a mouse model of osteogenesis imperfecta. Osteoporosis International, 23(3), pp. 1141-1150. doi: 10.1007/s00198-011-1742-7

  • Canuto, H.C., Fishbein, K.W., Huang, A., Doty, S.B., Herbert, R.A., Peckham, J., Pleshko, N., & Spencer, R.G. (2012). Characterization of skin abnormalities in a mouse model of osteogenesis imperfecta using high resolution magnetic resonance imaging and Fourier transform infrared imaging spectroscopy. NMR in Biomedicine, 25(1), pp. 169-176. doi: 10.1002/nbm.1732

  • Cheheltani, R., Rosano, J.M., Wang, B., Sabri, A.K., Pleshko, N., & Kiani, M.F. (2012). Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction. Journal of Biomedical Optics, 17(5), p. 056014. doi: 10.1117/1.jbo.17.5.056014

  • Kim, M., Kraft, J.J., Volk, A.C., Pugarelli, J., Pleshko, N., & Dodge, G.R. (2011). Characterization of a cartilage-like engineered biomass using a self-aggregating suspension culture model: Molecular composition using FT-IRIS. Journal of Orthopaedic Research, 29(12), pp. 1881-1887. doi: 10.1002/jor.21467

  • Reiter, D.A., Roque, R.A., Lin, P.C., Doty, S.B., Pleshko, N., & Spencer, R.G. (2011). Improved specificity of cartilage matrix evaluation using multiexponential transverse relaxation analysis applied to pathomimetically degraded cartilage. NMR in Biomedicine, 24(10), pp. 1286-1294. doi: 10.1002/nbm.1690

  • Mahmoodian, R., Leasure, J., Philip, P., Pleshko, N., Capaldi, F., & Siegler, S. (2011). Changes in mechanics and composition of human talar cartilage anlagen during fetal development. Osteoarthritis and Cartilage, 19(10), pp. 1199-1209. doi: 10.1016/j.joca.2011.07.013

  • Kavukcuoglu, N.B. & Pleshko, N. (2011). Infrared and Raman microscopy and imaging of biomaterials. In Comprehensive Biomaterials, 3 (pp. 365-378).

  • Li, Q., Kavukcuoglu, N.B., Pleshko, N., & Uitto, J. (2011). Element Composition Status and Mineral Deposits in the Abcc6(-/-) Mice, a Model for Pseudoxanthoma Elasticum. JOURNAL of INVESTIGATIVE DERMATOLOGY, 131, pp. S71-S71. Retrieved from http://gateway.webofknowledge.com/

  • Arteaga-Solis, E., Sui-Arteaga, L., Kim, M., Schaffler, M.B., Jepsen, K.J., Pleshko, N., & Ramirez, F. (2011). Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biology, 30(3), pp. 188-194. doi: 10.1016/j.matbio.2011.03.004

  • Irrechukwu, O.N., Lin, P.C., Fritton, K., Doty, S., Pleshko, N., & Spencer, R.G. (2011). Magnetic resonance studies of macromolecular content in engineered cartilage treated with pulsed low-intensity ultrasound. Tissue Engineering - Part A, 17(3-4), pp. 407-415. doi: 10.1089/ten.tea.2010.0187

  • Reiter, D.A., Roque, R.A., Lin, P.C., Irrechukwu, O., Doty, S., Longo, D.L., Pleshko, N., & Spencer, R.G. (2011). Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis. Magnetic Resonance in Medicine, 65(2), pp. 377-384. doi: 10.1002/mrm.22673

  • Raghavan, M., Sahar, N.D., Wilson, R.H., Mycek, M.A., Pleshko, N., Kohn, D.H., & Morris, M.D. (2010). Polarized Raman spectroscopy of bone tissue: Watch the scattering. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7548. doi: 10.1117/12.841977

  • Baykal, D., Irrechukwu, O., Lin, P.C., Fritton, K., Spencer, R.G., & Pleshko, N. (2010). Nondestructive assessment of engineered cartilage constructs using near-infrared spectroscopy. Applied Spectroscopy, 64(10), pp. 1160-1166. doi: 10.1366/000370210792973604

  • Colon, A., Parvizi, J., Pleshko, N., Williams, C.J., & Freeman, T.A. (2010). EXPRESSION PROFILING OF SKELETOGENIC-RELEVANT PATHWAYS REVEALS CONTRASTING PATHOGENETIC MECHANISMS IN MENISCAL RNA FROM OSTEOARTHRITIS VERSUS CHONDROCALCINOSIS PATIENTS. OSTEOARTHRITIS and CARTILAGE, 18, pp. S219-S219. doi: 10.1016/S1063-4584(10)60514-6

  • Kim, M., Foo, L.F., Uggen, C., Lyman, S., Ryaby, J.T., Moynihan, D.P., Grande, D.A., Potter, H.G., & Pleshko, N. (2010). Evaluation of early osteochondral defect repair in a rabbit model utilizing fourier transform-infrared imaging spectroscopy, magnetic resonance imaging, and quantitative T2 mapping. Tissue Engineering - Part C: Methods, 16(3), pp. 355-364. doi: 10.1089/ten.tec.2009.0020

  • Raghavan, M., Sahar, N.D., Wilson, R.H., Mycek, M.A., Pleshko, N., Kohn, D.H., & Morris, M.D. (2010). Quantitative polarized Raman spectroscopy in highly turbid bone tissue. Journal of Biomedical Optics, 15(3). doi: 10.1117/1.3426310

  • Gurkan, I., Ranganathan, A., Yang, X., Horton, W.E., Todman, M., Huckle, J., Pleshko, N., & Spencer, R.G. (2010). Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment. Osteoarthritis and Cartilage, 18(5), pp. 724-733. doi: 10.1016/j.joca.2010.01.006

  • Hawkins, J., Cifuentes, M., Pleshko, N.L., Ambia-Sobhan, H., & Shapses, S.A. (2010). Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not obese female rats (Journal of Nutrition (2010) 140, (31-37)). Journal of Nutrition, 140(4), p. 877. doi: 10.3945/jn.110.121111

  • Cheheltani, R., Rosano, J.M., Wang, B., Pleshko, N., & Kiani, M.F. (2010). Targeted VEGF Therapy Favorably Alters Collagen Deposition and Quality after Myocardial Infarction. FASEB JOURNAL, 24. Retrieved from http://gateway.webofknowledge.com/

  • Bargman, R., Huang, A., Boskey, A.L., Raggio, C., & Pleshko, N. (2010). RANKL inhibition improves bone properties in a mouse model of osteogenesis imperfecta. Connective Tissue Research, 51(2), pp. 123-131. doi: 10.3109/03008200903108472

  • Hawkins, J., Cifuentes, M., Pleshko, N.L., Ambia-Sobhan, H., & Shapses, S.A. (2010). Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not obese female rats. Journal of Nutrition, 140(1), pp. 31-37. doi: 10.3945/jn.109.111450

  • Leasure, J., Mahmoodian, R., Siegler, S., Capaldi, F., & Pleshko, N. (2009). Fourier transform infrared spectroscopic assessment of changes in composition of proteoglycans and collagen in developing human fetal tarsal bones. ASME International Mechanical Engineering Congress and Exposition, Proceedings, 2, pp. 553-560. doi: 10.1115/IMECE2008-67862

  • Herman, B.C., Kundi, R., Yamanouchi, D., Kent, K.C., Liu, B., & Pleshko, N. (2009). Molecular analysis of arterial remodeling: a novel application of infrared imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7182. doi: 10.1117/12.809425

  • Raggio, C.L., Fishbein, K.W., Carter, E.M., Kim, M., Pleshko, N., & Spencer, R.G. (2008). Identification of Skin Abnormalities in Osteogenesis Imperfecta Patients by Magnetic Resonance Imaging-A Pilot Study. JOURNAL of BONE and MINERAL RESEARCH, 23, pp. S240-S240. Retrieved from http://gateway.webofknowledge.com/

  • Pearson, K.J., Baur, J.A., Lewis, K.N., Peshkin, L., Price, N.L., Labinskyy, N., Swindell, W.R., Kamara, D., Minor, R.K., Perez, E., Jamieson, H.A., Zhang, Y., Dunn, S.R., Sharma, K., Pleshko, N., Woollett, L.A., Csiszar, A., Ikeno, Y., Couteur, D.L.e., Elliott, P.J., Becker, K.G., Navas, P., Ingram, D.K., Wolf, N.S., Ungvari, Z., Sinclair, D.A., & Cabo, R.d.e. (2008). Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metabolism, 8(2), pp. 157-168. doi: 10.1016/j.cmet.2008.06.011

  • Millán, J.L., Narisawa, S., Lemire, I., Loisel, T.P., Boileau, G., Leonard, P., Gramatikova, S., Terkeltaub, R., Camacho, N.P., McKee, M.D., Crine, P., & Whyte, M.P. (2008). Enzyme replacement therapy for murine hypophosphatasia. Journal of Bone and Mineral Research, 23(6), pp. 777-787. doi: 10.1359/jbmr.071213

  • Zhang, H., Ricciardi, B.F., Yang, X., Shi, Y., Camacho, N.P., & Bostrom, M. (2008). Polymethylmethacrylate particles stimulate bone resorption of mature osteoclasts in vitro. Acta Orthopaedica, 79(2), pp. 281-288. doi: 10.1080/17453670710015166

  • Delos, D., Yang, X., Ricciardi, B.F., Myers, E.R., Bostrom, M., & Camacho, N.P. (2008). The effects of RANKL inhibition on fracture healing and bone strength in a mouse model of osteogenesis imperfecta. Journal of Orthopaedic Research, 26(2), pp. 153-164. doi: 10.1002/jor.20469

  • Yang, X., Ricciardi, B.F., Hernandez-Soria, A., Shi, Y., Camacho, N.P., & Bostrom, M. (2007). Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. Bone, 41(6), pp. 928-936. doi: 10.1016/j.bone.2007.07.022

  • Mendelsohn, R., Boskey, A.L., & Camacho, N.P. (2007). Infrared Microscopy and Imaging of Hard and Soft Tissues: Applications to Bone, Skin and Cartilage. In Spectrochemical Analysis Using Infrared Multichannel Detectors (pp. 234-260). doi: 10.1002/9780470988541.ch11

  • Zhang, H., Doty, S.B., Hughes, C., Dempster, D., & Camacho, N.P. (2007). Increased resorptive activity and accompanying morphological alterations in osteoclasts derived from the Oim/Oim mouse model of osteogenesis imperfecta. Journal of Cellular Biochemistry, 102(4), pp. 1011-1020. doi: 10.1002/jcb.21337

  • Miller, E., Delos, D., Baldini, T., Wright, T.M., & Camacho, N.P. (2007). Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone. Calcified Tissue International, 81(3), pp. 206-214. doi: 10.1007/s00223-007-9045-x

  • Cheng, C., Conte, E., Pleshko-Camacho, N., & Hidaka, C. (2007). Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix Biology, 26(7), pp. 541-553. doi: 10.1016/j.matbio.2007.05.006

  • Millan, J.L., Narisawa, S., Lemire, I., Loisel, T.P., Boileau, G., Leonard, P., McKee, M.D., Crine, P., Johnson, K., Terkeltaub, R., Camacho, N.P., & Whyte, M.P. (2007). Enzyme replacement therapy for murine hypophosphatasia. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S72-S72. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P. & Akhter, M.P. (2007). Mineral and matrix characteristics in mice with LRP5 G171V mutation. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S162-S163. Retrieved from http://gateway.webofknowledge.com/

  • Yadav, M.C., Narisawa, S., Johnson, K., Terkeltaub, R., Camacho, N.P., & Milian, J.L. (2007). Increased bone mineral density in transgenic mice over-expressing tissue-nonspecific alkaline phosphatase. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S66-S66. Retrieved from http://gateway.webofknowledge.com/

  • Millan, J.L., Narisawa, S., Lemire, I., Loisel, T., Boileau, G., Leonard, P., McKee, M.D., Crine, P., Johnson, K., Terkeltaub, R., Camacho, N.P., & Whyte, M.P. (2007). Enzyme replacement therapy for murine hypophosphatasia. BONE, 40(6), pp. S127-S128. Retrieved from http://gateway.webofknowledge.com/

  • Boskey, A. & Camacho, N.P. (2007). FT-IR imaging of native and tissue-engineered bone and cartilage. Biomaterials, 28(15), pp. 2465-2478. doi: 10.1016/j.biomaterials.2006.11.043

  • Bi, X., Yang, X., Bostrom, M., Bartusik, D., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., & Camacho, N.P. (2007). Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. Analytical and Bioanalytical Chemistry, 387(5), pp. 1601-1612. doi: 10.1007/s00216-006-0910-7

  • Fishbein, K.W., Canuto, H.C., Bajaj, P., Camacho, N.P., & Spencer, R.G. (2007). Optimal methods for the preservation of cartilage samples in MRI and correlative biochemical studies. Magnetic Resonance in Medicine, 57(5), pp. 866-873. doi: 10.1002/mrm.21189

  • Spencer, R.G., Calton, E.F., & Camacho, N.P. (2006). Statistical comparison of Fourier transform infrared spectra. Journal of Biomedical Optics, 11(6). doi: 10.1117/1.2393231

  • Franco, G.E.L., Huang, A., Camacho, N.P., Stone, D.S., & Blank, R.D. (2006). Increased young's modulus and hardness of Col1a2oim dentin. Journal of Dental Research, 85(11), pp. 1032-1036. doi: 10.1177/154405910608501111

  • Harmey, D., Johnson, K.A., Zelken, J., Camacho, N.P., Hoylaerts, M.F., Noda, M., Terkeltaub, R., & Millán, J.L. (2006). Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2-/- mice. Journal of Bone and Mineral Research, 21(9), pp. 1377-1386. doi: 10.1359/jbmr.060619

  • Zhang, H., Doty, S., Antoniv, T., Labissiere, A., & Camacho, N.P. (2006). An in vitro calvarial-osteoblast-osteociast co-culture system to assess remodeling abnormalities in the oim/oim mouse model of OI. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S432-S432. Retrieved from http://gateway.webofknowledge.com/

  • Harmey, D., Johnson, K.A., Zelken, J., Camacho, N.P., Hoylaerts, M.F., Noda, M., Terkeltaub, R., & Millan, J.L. (2006). Elevated skeletal osteopontin contributes to the hypophosphatasia phenotype in Akp2-/- mice. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S12-S12. Retrieved from http://gateway.webofknowledge.com/

  • Zhu, J., Huang, A., Bi, X., Zhang, H., & Camacho, N.P. (2006). Quantification of osteoclastic resorption on bone slices by infrared imaging. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S212-S213. Retrieved from http://gateway.webofknowledge.com/

  • Bi, X., Yang, X., Bostrom, M., & Camacho, N.P. (2006). Fourier transform infrared imaging spectroscopy investigations in the pathogenesis and repair of cartilage. Biochimica Et Biophysica Acta - Biomembranes, 1758(7), pp. 934-941. doi: 10.1016/j.bbamem.2006.05.014

  • Garimella, R., Bi, X., Anderson, H.C., & Camacho, N.P. (2006). Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: An FTIR imaging study. Bone, 38(6), pp. 811-817. doi: 10.1016/j.bone.2005.11.027

  • Southern, D., Lutz, G., Bracilovic, A., West, P., Spevak, M., Camacho, N.P., & Doty, S. (2006). Histological and molecular structure characterization of annular collagen after intradiskal electrothermal annuloplasty. HSS Journal, 2(1), pp. 49-54. doi: 10.1007/s11420-005-0126-y

  • Li, G., Thomson, M., Dicarlo, E., Yang, X., Nestor, B., Bostrom, M., & Camacho, N.P. (2005). A chemometric analysis for evaluation of early-stage cartilage degradation by infrared fiber-optic probe spectroscopy. Applied Spectroscopy, 59(12), pp. 1527-1533. doi: 10.1366/000370205775142593

  • Bi, X., Li, G., Doty, S.B., & Camacho, N.P. (2005). A novel method for determination of collagen orientation in cartilage by Fourier transform infrared imaging spectroscopy (FT-IRIS). Osteoarthritis and Cartilage, 13(12), pp. 1050-1058. doi: 10.1016/j.joca.2005.07.008

  • Draper, E., Morris, M.D., Camacho, N.P., Matousek, P., Towrie, M., Parker, A.W., & Goodship, A.E. (2005). Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy. Journal of Bone and Mineral Research, 20(11), pp. 1968-1972. doi: 10.1359/JBMR.050710

  • Franco, G., Stone, D., Huang, A., Camacho, N.P., & Blank, R.D. (2005). Mechanical consequences of the Colla2(oim) mutation in mouse dentin. JOURNAL of BONE and MINERAL RESEARCH, 20(9), pp. S417-S417. Retrieved from http://gateway.webofknowledge.com/

  • Morris, M.D., Draper, E., Goodship, A.E., Matousek, P., Towrie, M., Parker, A.W., & Camacho, N.P. (2005). Picosecond time-gated Raman spectroscopy for transcutaneous evaluation of bone composition. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5693, pp. 344-350. doi: 10.1117/12.585457

  • Franco, G.E.L., Huang, A., Camacho, N.P., & Blank, R.D. (2005). Dental phenotype of the col1a2oim mutation: DI is present in both homozygotes and heterozygotes. Bone, 36(6), pp. 1039-1046. doi: 10.1016/j.bone.2005.03.004

  • Kim, M., Bi, X., Horton, W.E., Spencer, R.G., & Camacho, N.P. (2005). Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: Histologic and biochemical correlations. Journal of Biomedical Optics, 10(3). doi: 10.1117/1.1922329

  • Anderson, H.C., Harmey, D., Camacho, N.P., Garimella, R., Sipe, J.B., Tague, S., Bi, X., Johnson, K., Terkeltaub, R., & Millán, J.L. (2005). Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. American Journal of Pathology, 166(6), pp. 1711-1720. doi: 10.1016/S0002-9440(10)62481-9

  • West, P.A., Torzilli, P.A., Chen, C., Lin, P., & Camacho, N.P. (2005). Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation. Journal of Biomedical Optics, 10(1). doi: 10.1117/1.1854131

  • Misof, B.M., Roschger, P., Baldini, T., Raggio, C.L., Zraick, V., Root, L., Boskey, A.L., Klaushofer, K., Fratzl, P., & Camacho, N.P. (2005). Differential effects of alendronate treatment on bone from growing osteogenesis imperfecta and wild-type mouse. Bone, 36(1), pp. 150-158. doi: 10.1016/j.bone.2004.10.006

  • Franco, G., Huang, A., Camacho, N.P., & Blank, R.D. (2004). Colla2(oim) mice express dentinogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S100-S100. Retrieved from http://gateway.webofknowledge.com/

  • Anderson, H.C., Harmey, D., Camacho, N.P., Garimella, R., Sipe, J.B., Tague, S., Terkeltaub, R., & Millan, J.L. (2004). Hypornineralization of tibia in nucleoside triphosphate pyrophosphohydrolase (NPP1) deficient mice. JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S61-S61. Retrieved from http://gateway.webofknowledge.com/

  • Zhang, H., Hughes, C., Raggio, C., Dempster, D.W., & Camacho, N.P. (2004). Increased early resorption activity and alterations of morphology in osteoclasts derived from the oim/oim mouse model of osteogenesis imperfecta (OI). JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S330-S330. Retrieved from http://gateway.webofknowledge.com/

  • Garimella, R., Bi, X., Camacho, N., Sipe, J.B., & Anderson, H.C. (2004). Primary culture of rat growth plate chondrocytes: An in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization. Bone, 34(6), pp. 961-970. doi: 10.1016/j.bone.2004.02.010

  • West, P.A., Bostrom, M., Torzilli, P.A., & Camacho, N.P. (2004). Fourier transform infrared spectral analysis of degenerative cartilage: An infrared fiber optic probe and imaging study. Applied Spectroscopy, 58(4), pp. 376-381. doi: 10.1366/000370204773580194

  • Anderson, H.C., Sipe, J.B., Hessle, L., Dhamyamraju, R., Atti, E., Camacho, N.P., & Millán, J.L. (2004). Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase-Deficient Mice. American Journal of Pathology, 164(3), pp. 841-847. doi: 10.1016/S0002-9440(10)63172-0

  • Quenzer, J., Boachie-Adjei, K., Hao, A., Dunstan, C., Raggio, C.L., & Camacho, N.P. (2003). Treatment of OIM mice with osteoprotegerin. JOURNAL of BONE and MINERAL RESEARCH, 18, pp. S33-S33. Retrieved from http://gateway.webofknowledge.com/

  • Ling, S.M., Bang, D., Camacho, N.P., Yang, X., & Spencer, R.G. (2003). Micro-computed tomographic assessment of bone quality in an animal model of arthritis and unloading. ARTHRITIS and RHEUMATISM, 48(9), pp. S491-S491. Retrieved from http://gateway.webofknowledge.com/

  • Bonewald, L.F., Harris, S.E., Rosser, J., Dallas, M.R., Dallas, S.L., Camacho, N.P., Boyan, B., & Boskey, A. (2003). Von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation. Calcified Tissue International, 72(5), pp. 537-547. doi: 10.1007/s00223-002-1057-y

  • Camacho, N.P., Carroll, P., & Raggio, C.L. (2003). Fourier transform infrared imaging spectroscopy (FT-IRIS) of mineralization in bisphosphonate-treated oim/oim mice. Calcified Tissue International, 72(5), pp. 604-609. doi: 10.1007/s00223-002-1038-1

  • McCarthy, E.A., Camacho, N.P., Raggio, C.L., Lawrence, L., Rahman, M., Garcia, R., & Hendricks-Munoz, K. (2003). Pilot study of in utero treatment of osteogenesis imperfecta (OI) with alendronate: Feasibility demonstrated in wildtype mouse model. PEDIATRIC RESEARCH, 53(4), pp. 53A-54A. Retrieved from http://gateway.webofknowledge.com/

  • Sims, T.J., Miles, C.A., Bailey, A.J., & Camacho, N.P. (2003). Properties of collagen in OIM mouse tissues. Connective Tissue Research, 44(SUPPL. 1), pp. 202-205. doi: 10.1080/713713620

  • McCarthy, E.A., Raggio, C.L., Hossack, M.D., Miller, E.A., Jain, S., Boskey, A.L., & Camacho, N.P. (2002). Alendronate treatment for infants with osteogenesis imperfecta: Demonstration of efficacy in a mouse model. Pediatric Research, 52(5), pp. 660-670. doi: 10.1203/00006450-200211000-00010

  • McCarthy, E.A., Raggio, C.L., Hossack, M.D., Miller, E.A., Jain, S., Boskey, A.L., & Camacho, N.P. (2002). Alendronate Treatment for Infants with Osteogenesis Imperfecta: Demonstration of Efficacy in a Mouse Model. Pediatric Research, 52(5), pp. 660-670. Springer Science and Business Media LLC. doi: 10.1203/00006450-200211000-00010

  • Aparicio, S., Doty, S.B., Camacho, N.P., Paschalis, E.P., Spevak, L., Mendelsohn, R., & Boskey, A.L. (2002). Optimal methods for processing mineralized tissues for Fourier transform infrared microspectroscopy. Calcified Tissue International, 70(5), pp. 422-429. doi: 10.1007/s00223-001-1016-z

  • Hsu, H., Camacho, N.C., Tawfik, O., & Sun, F. (2002). Induction of calcification in rabbit aortas by high cholesterol diets: Roles of calcifiable vesicles in dystrophic calcification. Atherosclerosis, 161(1), pp. 85-94. doi: 10.1016/S0021-9150(01)00623-2

  • Miles, C.A., Sims, T.J., Camacho, N.P., & Bailey, A.J. (2002). The role of the a2 chain in the stabilization of the collagen type I heterotrimer: A study of the type I homotrimer in oim mouse tissues. Journal of Molecular Biology, 321(5), pp. 797-805. doi: 10.1016/S0022-2836(02)00703-9

  • Camacho, N.P., West, P., Griffith, M.H., Warren, R.F., & Hidaka, C. (2001). FT-IR imaging spectroscopy of genetically modified bovine chondrocytes. Materials Science and Engineering C, 17(1-2), pp. 3-9. doi: 10.1016/S0928-4931(01)00326-5

  • Patani, A.N., Pincavage, A., Bankston, J., Camacho, N.P., & Blank, R.D. (2001). Use of representational difference analysis to identify candidate RFLPs linked to modifiers of the murine Cola2(oim/oim) osteogenesis imperfecta phenotype. JOURNAL of BONE and MINERAL RESEARCH, 16, pp. S304-S304. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Tivol, W., Buttle, K., Raggio, C.L., Doty, S.B., & Landis, W.J. (2001). Comparison of mineral characteristics in oim/oim mice and human osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 16, pp. S422-S422. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Raggio, C.L., Doty, S.B., Root, L., Zraick, V., Ilg, W.A., Toledano, T.R., & Boskey, A.L. (2001). A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta. Calcified Tissue International, 69(2), pp. 94-101. doi: 10.1007/s002230010045

  • Hsu, H., Camacho, N.P., Tawfik, O., & Sun, F. (2001). Effects of high cholesterol feeding on arterial and vesicle calcification using rabbit as a model. BONE, 28(5), pp. S101-S102. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., West, P., Torzilli, P.A., & Mendelsohn, R. (2001). FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. Biopolymers - Biospectroscopy Section, 62(1), pp. 1-8. doi: 10.1002/1097-0282(2001)62:13.0.CO;2-O

  • Camacho, N.P., West, P., Torzilli, P.A., & Mendelsohn, R. (2001). FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. BIOPOLYMERS, 62(1), pp. 1-8. doi: 10.1002/1097-0282(2001)62:13.0.CO;2-O

  • Hsu, H., Camacho, N.P., Sun, F., Tawfik, O., & Aono, H. (2000). Isolation of calcifiable vesicles from aortas of rabbits fed with high cholesterol diets. Atherosclerosis, 153(2), pp. 337-348. doi: 10.1016/S0021-9150(00)00425-1

  • Camacho, N.P., Raggio, C.L., & Blank, R.D. (2000). Osteogenesis imperfecta. Current Opinion in Orthopaedics, 11(5), pp. 341-346. doi: 10.1097/00001433-200010000-00003

  • Camacho, N.P., McCarthy, E.A., Jain, S., Gupta, R., Wurzburger, R., Raggio, C.L., & Blank, R.D. (2000). Emergence of fracture-resistant Cola2(oim/oim) mice. JOURNAL of BONE and MINERAL RESEARCH, 15, pp. S484-S484. Retrieved from http://gateway.webofknowledge.com/

  • McCarthy, E.A., Hossack, M., Miller, E.A., Zraick, V., Jain, M., Boacci, O., Raggio, C., & Camacho, N.P. (2000). Osteogenesis imperfecta: Alendronate reduces fractures and corrects spinal curvature in infant mouse model. PEDIATRIC RESEARCH, 47(4), pp. 415A-415A. Retrieved from http://gateway.webofknowledge.com/

  • Brown, C.W., Bu, D., Camacho, N.P., & Mendelsohn, R. (2000). Mechanisms for the conversion of hyperspectral images to chemical images. Proceedings of SPIE - the International Society for Optical Engineering, 3920, pp. 118-128.

  • Bostrom, M., Hossack, M.D., Miller, E.A., Gamradt, S.C., & Camacho, N.P. (1999). The effect of alendronate in a new mouse femur fracture model. JOURNAL of BONE and MINERAL RESEARCH, 14, pp. S208-S208. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Rinnerthaler, S., Paschalis, E.P., Mendelsohn, R., Boskey, A.L., & Fratzl, P. (1999). Complementary information on bone ultrastructure from scanning small angle X-ray scattering and Fourier-transform infrared microspectroscopy. Bone, 25(3), pp. 287-293. doi: 10.1016/S8756-3282(99)00165-9

  • McCarthy, E.A., Hossack, M., Miller, E.A., Raggio, C., & Camacho, N.P. (1999). Alendronate reduces fractures and corrects spinal curvature in infant mouse model of osteogenesis imperfecta. PEDIATRIC RESEARCH, 45(4), pp. 210A-210A. doi: 10.1203/00006450-199904020-01251

  • Hsu, H. & Camacho, N.P. (1999). Isolation of calcifiable vesicles from human atherosclerotic aortas. Atherosclerosis, 143(2), pp. 353-362. doi: 10.1016/S0021-9150(98)00322-0

  • Camacho, N.P., Hou, L., Toledano, T.R., Ilg, W.A., Brayton, C.F., Raggio, C.L., Root, L., & Boskey, A.L. (1999). The material basis for reduced mechanical properties in oim mice bones. Journal of Bone and Mineral Research, 14(2), pp. 264-272. doi: 10.1359/jbmr.1999.14.2.264

  • Hsu, H., Camacho, N.P., & Anderson, H.C. (1999). Further characterization of ATP-initiated calcification by matrix vesicles isolated from rachitic rat cartilage: Membrane perturbation by detergents and deposition of calcium pyrophosphate by rachitic matrix vesicles. Biochimica Et Biophysica Acta - Biomembranes, 1416(1-2), pp. 320-332. doi: 10.1016/S0005-2736(98)00235-1

  • Blank, R.D., Raggio, C.L., Giampietro, P.F., & Camacho, N.P. (1999). A genomic approach to scoliosis pathogenesis. Lupus, 8(5), pp. 356-360. doi: 10.1177/096120339900800505

  • Derfus, B., Kranendonk, S., Camacho, N., Mandel, N., Kushnaryov, V., Lynch, K., & Ryan, L. (1998). Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro. Calcified Tissue International, 63(3), pp. 258-262. doi: 10.1007/s002239900523

  • Camacho, N.P., Dow, D., Toledano, T.R., Buckmeyer, J.K., Gertner, J.M., Brayton, C.F., Raggio, C.L., Root, L., & Boskey, A.L. (1998). Identification of the oim mutation by dye terminator chemistry combined with automated direct DNA sequencing. Journal of Orthopaedic Research, 16(1), pp. 38-42. doi: 10.1002/jor.1100160107

  • Bostrom, M. & Camacho, N.P. (1998). Potential role of bone morphogenetic proteins in fracture healing. Clinical Orthopaedics and Related Research, 355(SUPPL.). doi: 10.1097/00003086-199810001-00028

  • Camacho, N.P., Brayton, C.F., Buckmeyer, J., Raggio, C.L., Root, L., Toledano, T., & Boskey, A.L. (1997). Evaluation of alendronate for treatment in an animal model of osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 12, pp. F654-F654. Retrieved from http://gateway.webofknowledge.com/

  • Pienkowski, D., Doers, T.M., Monier-Faugere, M.C., Geng, Z., Camacho, N.P., Boskey, A.L., & Malluche, H.H. (1997). Calcitonin alters bone quality in beagle dogs. Journal of Bone and Mineral Research, 12(11), pp. 1936-1943. doi: 10.1359/jbmr.1997.12.11.1936

  • Camacho, N.P., Hou, L., Schenkel, B., Raggio, C.L., & Boskey, A.L. (1997). Abnormal mineralization reduces bone mechanical properties in the oim mouse. JOURNAL of DENTAL RESEARCH, 76, pp. 2189-2189. Retrieved from http://gateway.webofknowledge.com/

  • Derfus, B.A., Kurtin, S.M., Camacho, N.P., Kurup, I., & Ryan, L.M. (1996). Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. Connective Tissue Research, 35(1-4), pp. 391-396.

  • Camacho, N.P., Landis, W.J., & Boskey, A.L. (1996). Mineral changes in a mouse model of osteogenesis imperfecta detected by fourier transform infrared microscopy. Connective Tissue Research, 35(1-4), pp. 313-319.

  • Bonewald, L.F., Dallas, S., Qiao, M., Camacho, N.P., Boyan, B., & Boskey, A. (1996). Comparison of mineralized matrix of fetal rat calvarial cells and MC-3T3-E1 osteoblast-like cells by Fourier transform infrared spectroscopy (FT-IR). JOURNAL of BONE and MINERAL RESEARCH, 11, pp. S333-S333. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Brayton, C., Gertner, J., Raggio, C.L., Root, L., & Boskey, A.L. (1996). Effect of a third generation bisphosphonate on bone properties in the oim mouse. JOURNAL of BONE and MINERAL RESEARCH, 11, pp. M613-M613. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P. (1996). Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora (vol 17, pg 271, 1995). BONE, 19(1), pp. 77-77. Retrieved from http://gateway.webofknowledge.com/

  • Derfus, B.A., Kurtin, S.M., Camacho, N.P., Kurup, I., & Ryan, L.M. (1996). Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. Connective Tissue Research, 35(1-4), pp. 337-342. doi: 10.3109/03008209609029209

  • Camacho, N.P., Landis, W.J., & Boskey, A.L. (1996). Mineral changes in a mouse model of osteogenesis imperfecta detected by fourier transform infrared microscopy. Connective Tissue Research, 35(1-4), pp. 259-265. doi: 10.3109/03008209609029199

  • Gadaleta, S.J., Camacho, N.P., Mendelsohn, R., & Boskey, A.L. (1996). Fourier transform infrared microscopy of calcified turkey leg tendon. Calcified Tissue International, 58(1), pp. 17-23. doi: 10.1007/BF02509541

  • Camacho, N.P. & et, A. (1996). Erratum: Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora (Bone (1995) 17 (271-278)). Bone, 19(1), p. 77. doi: 10.1016/8756-3282(96)00104-4

  • Camacho, N.P., Raggio, C.L., Brayton, C., & Boskey, A.L. (1996). Analysis of dentin in osteogenesis imperfecta. JOURNAL of DENTAL RESEARCH, 75, pp. 212-212. Retrieved from http://gateway.webofknowledge.com/

  • CAMACHO, N.P., MENDELSOHN, R., DICARLO, E., & BOSKEY, A.L. (1995). CHANGES IN OSTEOPOROTIC BONE-MINERAL WITH NAF TREATMENT AS DETECTED BY FOURIER-TRANSFORM INFRARED MICROSCOPY. JOURNAL of BONE and MINERAL RESEARCH, 10, pp. S355-S355. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Rimnac, C.M., Meyer, R.A., Doty, S., & Boskey, A.L. (1995). Effect of abnormal mineralization on the mechanical behavior of x-linked hypophosphatemic mice femora. Bone, 17(3), pp. 271-278. doi: 10.1016/8756-3282(95)00210-5

  • Gadaleta, S.J., Mendelsohn, R., Paschalis, E.L., Camacho, N.P., Betts, F., & Boskey, A.L. (1995). Fourier transform infrared spectroscopy of synthetic and biological apatites - A review. MINERAL SCALE FORMATION and INHIBITION, pp. 283-294. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Smith, D.R., Goldman, A., Schneider, B., Green, D., Young, P.R., & Berman, H.M. (1993). Structure of an Interleukin-1ß Mutant with Reduced Bioactivity Shows Multiple Subtle Changes in Conformation That Affect Protein-Protein Recognition. Biochemistry, 32(34), pp. 8749-8757. doi: 10.1021/bi00085a005

  • Boskey, A.L., Camacho, N.P., Mendelsohn, R., Doty, S.B., & Binderman, I. (1992). FT-IR microscopic mappings of early mineralization in chick limb bud mesenchymal cell cultures. Calcified Tissue International, 51(6), pp. 443-448. doi: 10.1007/BF00296678

  • Pleshko, N.L., Boskey, A.L., & Mendelsohn, R. (1992). An FT-IR microscopic investigation of the effects of tissue preservation on bone. Calcified Tissue International, 51(1), pp. 72-77. doi: 10.1007/BF00296221

  • Pleshko, N.L., Boskey, A.L., & Mendelsohn, R. (1992). An infrared study of the interaction of polymethyl methacrylate with the protein and mineral components of bone. Journal of Histochemistry and Cytochemistry, 40(9), pp. 1413-1417. doi: 10.1177/40.9.1506677

  • BOSKEY, A.L., PLESHKO, N., DOTY, S.B., & MENDELSOHN, R. (1992). APPLICATIONS OF FOURIER-TRANSFORM INFRARED (FT-IR) MICROSCOPY TO THE STUDY OF MINERALIZATION IN BONE AND CARTILAGE. CELLS and MATERIALS, 2(3), pp. 209-220. Retrieved from http://gateway.webofknowledge.com/

  • Pleshko, N., Boskey, A., & Mendelsohn, R. (1991). Novel infrared spectroscopic method for the determination of crystallinity of hydroxyapatite minerals. Biophysical Journal, 60(4), pp. 786-793. doi: 10.1016/S0006-3495(91)82113-0

  • Mendelsohn, R., Hassankhani, A., Pleshko, N., DiCarlo, E., & Boskey, A. (1989). FT-IR microscopy of biomineralization at 20µ spatial resolution. Proceedings of SPIE - the International Society for Optical Engineering, 1145, pp. 403-404. doi: 10.1117/12.969521

  • Shanas, N., Querido, W., Oswald, J., Jepsen, K., Carter, E., Raggio, C., & Pleshko, N. EXPRESS: Infrared Spectroscopy-Determined Bone Compositional Changes Associated with Anti-Resorptive Treatment of the Oim/Oim Mouse Model of Osteogenesis Imperfecta. Applied Spectroscopy, pp. 000370282110554-000370282110554. SAGE Publications. doi: 10.1177/00037028211055477