Biography

Dr. Nancy Pleshko is a Professor in the Department of Bioengineering at Temple University, Philadelphia, PA. Dr. Pleshko is recognized for her research on assessment of tissues at the molecular, cellular, and structural level through application of state-of-the-art vibrational spectroscopy. She has substantial expertise in basic and translational research in connective tissue pathophysiology and orthopedics, including osteoporosis and other bone pathologies, and osteoarthritis and cartilage repair. She has over 90 publications, and has received over $5 million in federal funding.

Research Interests

  • Molecular Imaging of Tissues & Cells
  • Spectroscopic Analysis Techniques for Cartilage and Bone Pathologies
  • Tissue Engineering
  • Contribution of Molecular Alterations in Connective Tissue on Mechanical Behavior
  • MicroCT & Magnetic Resonance Imaging of Connective Tissues

Courses Taught

Number

Name

Level

BIOE 0856

Ethical Issues in Biomedical Science, Engineering and Technology

Undergraduate

ENGG 3385

Diamond Peer Teachers - Internship I

Undergraduate

Selected Publications

  • Querido, W., Zouaghi, S., Padalkar, M., Morman, J., Falcon, J., Kandel, S., & Pleshko, N. (2022). Nondestructive assessment of tissue engineered cartilage based on biochemical markers in cell culture media: application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Analyst, 147(8), pp. 1730-1741. England. doi: 10.1039/d1an02351a

  • Shanas, N., Querido, W., Oswald, J., Jepsen, K., Carter, E., Raggio, C., & Pleshko, N. (2022). Infrared Spectroscopy-Determined Bone Compositional Changes Associated with Anti-Resorptive Treatment of the oim/oim Mouse Model of Osteogenesis Imperfecta. Appl Spectrosc, 76(4), pp. 416-427. United States. doi: 10.1177/00037028211055477

  • Gidde, S.T.R., Acharya, S.R., Kandel, S., Pleshko, N., & Hutapea, P. (2022). Assessment of tissue damage from mosquito-inspired surgical needle. Minim Invasive Ther Allied Technol, pp. 1-10. England. doi: 10.1080/13645706.2022.2051718

  • Falcon, J.M., Chirman, D., Veneziale, A., Morman, J., Bolten, K., Kandel, S., Querido, W., Freeman, T., & Pleshko, N. (2021). DMOG Negatively Impacts Tissue Engineered Cartilage Development. Cartilage, 13(2_suppl), pp. 722S-733S. United States. doi: 10.1177/1947603520967060

  • Miguez, P.A., Tuin, S.A., Robinson, A.G., Belcher, J., Jongwattanapisan, P., Perley, K., Gonҫalves, V.d.e.P., Hanifi, A., Pleshko, N., & Barton, E.R. (2021). Hesperidin Promotes Osteogenesis and Modulates Collagen Matrix Organization and Mineralization In Vitro and In Vivo. Int J Mol Sci, 22(6). Switzerland. doi: 10.3390/ijms22063223

  • Sanden, K.W., Böcker, U., Ofstad, R., Pedersen, M.E., Høst, V., Afseth, N.K., Rønning, S.B., & Pleshko, N. (2021). Characterization of Collagen Structure in Normal, Wooden Breast and Spaghetti Meat Chicken Fillets by FTIR Microspectroscopy and Histology. Foods, 10(3). Switzerland. doi: 10.3390/foods10030548

  • Querido, W., Kandel, S., & Pleshko, N. (2021). Applications of Vibrational Spectroscopy for Analysis of Connective Tissues. Molecules, 26(4). Switzerland. doi: 10.3390/molecules26040922

  • Jones, B.C., Jia, S., Lee, H., Feng, A., Shetye, S.S., Batzdorf, A., Shapira, N., Noël, P.B., Pleshko, N., & Rajapakse, C.S. (2021). MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora. Bone, 143, p. 115774. United States. doi: 10.1016/j.bone.2020.115774

  • Afara, I.O., Shaikh, R., Nippolainen, E., Querido, W., Torniainen, J., Sarin, J.K., Kandel, S., Pleshko, N., & Töyräs, J. (2021). Characterization of connective tissues using near-infrared spectroscopy and imaging. Nat Protoc, 16(2), pp. 1297-1329. England. doi: 10.1038/s41596-020-00468-z

  • Chirman, D. & Pleshko, N. (2021). Characterization of bacterial biofilm infections with Fourier transform infrared spectroscopy: a review. Applied Spectroscopy Reviews, 56(8-10), pp. 673-701. doi: 10.1080/05704928.2020.1864392

  • Ailavajhala, R., Querido, W., Rajapakse, C.S., & Pleshko, N. (2020). Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water. Analyst, 145(10), pp. 3713-3724. England. doi: 10.1039/c9an02491c

  • Shanas, N., Querido, W., Dumont, A., Yonko, E., Carter, E., Ok, J., Karchner, J.P., Barbe, M.F., Ali, S., Patil, C., Raggio, C., & Pleshko, N. (2020). Clinical application of near infrared fiber optic spectroscopy for noninvasive bone assessment. J Biophotonics, 13(4), p. e201960172. Germany. doi: 10.1002/jbio.201960172

  • Kandel, S., Querido, W., Falcon, J.M., Reiners, D.J., & Pleshko, N. (2020). Approaches for In Situ Monitoring of Matrix Development in Hydrogel-Based Engineered Cartilage. Tissue Eng Part C Methods, 26(4), pp. 225-238. United States. doi: 10.1089/ten.TEC.2020.0014

  • Querido, W., Shanas, N., Bookbinder, S., Oliveira-Nunes, M.C., Krynska, B., & Pleshko, N. (2020). Fourier transform infrared spectroscopy of developing bone mineral: from amorphous precursor to mature crystal. Analyst, 145(3), pp. 764-776. England. doi: 10.1039/c9an01588d

  • Hong, A.L., Ispiryan, M., Padalkar, M.V., Jones, B.C., Batzdorf, A.S., Shetye, S.S., Pleshko, N., & Rajapakse, C.S. (2019). MRI-derived bone porosity index correlates to bone composition and mechanical stiffness. Bone Rep, 11, p. 100213. United States. doi: 10.1016/j.bonr.2019.100213

  • Shanas, N., Querido, W., Pleshko, N., Yonko, E., Carter, E., & Raggio, C. (2019). Non-invasive near infrared spectroscopic method for bone quality assessment in osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 34, pp. 190-191. Retrieved from http://gateway.webofknowledge.com/

  • Shanas, N., Querido, W., Pleshko, N., Yonko, E., Carter, E., & Raggio, C. (2019). Non-invasive near infrared spectroscopic method for bone quality assessment in osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 34, pp. 190-191. Retrieved from http://gateway.webofknowledge.com/

  • Karchner, J.P., Yousefi, F., Bitman, S.R., Darvish, K., & Pleshko, N. (2019). Non-Destructive Spectroscopic Assessment of High and Low Weight Bearing Articular Cartilage Correlates with Mechanical Properties. Cartilage, 10(4), pp. 480-490. United States. doi: 10.1177/1947603518764269

  • Ailavajhala, R., Oswald, J., Rajapakse, C.S., & Pleshko, N. (2019). Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water. Sci Rep, 9(1), p. 10199. England. doi: 10.1038/s41598-019-45897-3

  • Karchner, J.P., Querido, W., Kandel, S., & Pleshko, N. (2019). Spatial correlation of native and engineered cartilage components at micron resolution. Ann N Y Acad Sci, 1442(1), pp. 104-117. United States. doi: 10.1111/nyas.13934

  • Tint, D., Stabler, C.T., Hanifi, A., Yousefi, F., Linkov, G., Hy, K., Soliman, A.M.S., & Pleshko, N. (2019). Spectroscopic Analysis of Human Tracheal Tissue during Decellularization. Otolaryngol Head Neck Surg, 160(2), pp. 302-309. England. doi: 10.1177/0194599818806271

  • Wolfson, M.R., Pleshko, N., Darvish, K., Marcinkiewicz, M., Wu, J., Rakymzhan, A., Kyada, R., Enkhbaatar, P., Fukuda, S., Nelson, C., Williams, R.O., Komissarov, A., Florova, G., Shaffer, T.H., & Idell, S. (2019). Understanding Airway Casts Secondary to Inhalational Smoke-Induced Acute Lung Injury (ISALI): Independent Assessment Tools of Composition and Fibrinolysin Impact. AMERICAN JOURNAL of RESPIRATORY and CRITICAL CARE MEDICINE, 199. Retrieved from http://gateway.webofknowledge.com/

  • Querido, W., Ailavajhala, R., Padalkar, M., & Pleshko, N. (2018). Validated Approaches for Quantification of Bone Mineral Crystallinity Using Transmission Fourier Transform Infrared (FT-IR), Attenuated Total Reflection (ATR) FT-IR, and Raman Spectroscopy. Appl Spectrosc, 72(11), pp. 1581-1593. United States. doi: 10.1177/0003702818789165

  • Wischmann, J., Lenze, F., Thiel, A., Bookbinder, S., Querido, W., Schmidt, O., Burgkart, R., Eisenhart-Rothe, R.v., Richter, G.H.S., Pleshko, N., & Mayer-Kuckuk, P. (2018). Matrix mineralization controls gene expression in osteoblastic cells. Exp Cell Res, 372(1), pp. 25-34. United States. doi: 10.1016/j.yexcr.2018.09.005

  • Yousefi, F., Kandel, S., & Pleshko, N. (2018). Infrared Spectroscopic Quantification of Methacrylation of Hyaluronic Acid: A Scaffold for Tissue Engineering Applications. Appl Spectrosc, 72(10), pp. 1455-1466. United States. doi: 10.1177/0003702818785353

  • Choi, H., Tessier, S., Silagi, E.S., Kyada, R., Yousefi, F., Pleshko, N., Shapiro, I.M., & Risbud, M.V. (2018). A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biol, 70, pp. 102-122. Netherlands. doi: 10.1016/j.matbio.2018.03.019

  • Jongwattanapisan, P., Terajima, M., Miguez, P.A., Querido, W., Nagaoka, H., Sumida, N., Gurysh, E.G., Ainslie, K.M., Pleshko, N., Perera, L., & Yamauchi, M. (2018). Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function. Sci Rep, 8(1), p. 7022. England. doi: 10.1038/s41598-018-25279-x

  • Linkov, G., Hanifi, A., Yousefi, F., Tint, D., Bolla, S., Marchetti, N., Soliman, A.M.S., & Pleshko, N. (2018). Compositional Assessment of Human Tracheal Cartilage by Infrared Spectroscopy. Otolaryngol Head Neck Surg, 158(4), pp. 688-694. England. doi: 10.1177/0194599817752310

  • Yousefi, F., Kim, M., Nahri, S.Y., Mauck, R.L., & Pleshko, N. (2018). Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs. Tissue Eng Part A, 24(1-2), pp. 106-116. United States. doi: 10.1089/ten.TEA.2017.0035

  • Qu, D., Subramony, S.D., Boskey, A.L., Pleshko, N., Doty, S.B., & Lu, H.H. (2017). Compositional mapping of the mature anterior cruciate ligament-to-bone insertion. J Orthop Res, 35(11), pp. 2513-2523. United States. doi: 10.1002/jor.23539

  • Querido, W., Falcon, J.M., Kandel, S., & Pleshko, N. (2017). Vibrational spectroscopy and imaging: applications for tissue engineering. Analyst, 142(21), pp. 4005-4017. England. doi: 10.1039/c7an01055a

  • Rajapakse, C.S., Padalkar, M.V., Yang, H.J., Ispiryan, M., & Pleshko, N. (2017). Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements. Bone, 103, pp. 116-124. United States. doi: 10.1016/j.bone.2017.06.015

  • Doty, S.B., Bostrom, M.P., Bockman, R.S., Meulen, M.C.h.v.d., & Pleshko, N. (2017). Adele Ludin Boskey, PhD. J Bone Miner Res, 32(8), pp. 1597-1598. United States. doi: 10.1002/jbmr.3187

  • Hanifi, A., Palukuru, U., McGoverin, C., Shockley, M., Frank, E., Grodzinsky, A., Spencer, R.G., & Pleshko, N. (2017). Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties. Analyst, 142(8), pp. 1320-1332. England. doi: 10.1039/c6an02167k

  • Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. Cardiovasc Eng Technol, 8(1), pp. 70-80. United States. doi: 10.1007/s13239-016-0289-3

  • Spencer, R.G., Cortese, B.D., Lukas, V.A., & Pleshko, N. (2017). Point Estimates of Test Sensitivity and Specificity from Sample Means and Variances. American Statistician, 71(1), pp. 81-87. doi: 10.1080/00031305.2016.1239589

  • Marcott, C., Padalkar, M., & Pleshko, N. (2017). 3.23 Infrared and raman microscopy and imaging of biomaterials at the micro and nano scale. In Comprehensive Biomaterials II (pp. 498-518). doi: 10.1016/B978-0-12-803581-8.10183-3

  • Wolfson, M.R., Pleshko, N., Darvish, K.K., Baker, S.T., Wu, J., Kyada, R., Nelson, C., Fukuda, S., Enkhbaatar, P., Florova, G., Komissarov, A.A., Idell, S., & Shaffer, T.H. (2017). Differential Impact Of Fibrinolysins On Airway Cast Composition And Mechanical Properties Assessed By A Novel Infrared Imaging And Microindentation Approach. AMERICAN JOURNAL of RESPIRATORY and CRITICAL CARE MEDICINE, 195. Retrieved from http://gateway.webofknowledge.com/

  • Marcott, C., Padalkar, M., & Pleshko, N. (2017). Infrared and Raman Microscopy and Imaging of Biomaterials at the Micro and Nano Scale. In Comprehensive Biomaterials II (pp. 498-518). doi: 10.1016/b978-0-12-803581-8.10183-3

  • Gangolli, R.A., Devlin, S.M., Ailavajhala, R., Hanifi, A., Pleshko, N., Lelkes, P.I., & Yang, M. (2016). Biomimetic Scaffold to Regenerate the Pulp Dentin Complex. TISSUE ENGINEERING PART A, 22, pp. S72-S72. Retrieved from http://gateway.webofknowledge.com/

  • Bozkurt, O., Bilgin, M.D., Evis, Z., Pleshko, N., & Severcan, F. (2016). Early Alterations in Bone Characteristics of Type I Diabetic Rat Femur: A Fourier Transform Infrared (FT-IR) Imaging Study. Appl Spectrosc, 70(12), pp. 2005-2015. United States. doi: 10.1177/0003702816671059

  • Raggio, C.L., Pleshko, N., & Boskey, A.L. (2016). The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data. J Bone Miner Res, 31(11), p. 2065. United States. doi: 10.1002/jbmr.2976

  • Eisenhauer, P., Chernets, N., Song, Y., Dobrynin, D., Pleshko, N., Steinbeck, M.J., & Freeman, T.A. (2016). Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation. J Tissue Eng Regen Med, 10(9), pp. 772-782. England. doi: 10.1002/term.2224

  • Palukuru, U.P., Hanifi, A., McGoverin, C.M., Devlin, S., Lelkes, P.I., & Pleshko, N. (2016). Near infrared spectroscopic imaging assessment of cartilage composition: Validation with mid infrared imaging spectroscopy. Anal Chim Acta, 926, pp. 79-87. Netherlands. doi: 10.1016/j.aca.2016.04.031

  • McGoverin, C.M., Hanifi, A., Palukuru, U.P., Yousefi, F., Glenn, P.B.M., Shockley, M., Spencer, R.G., & Pleshko, N. (2016). Nondestructive Assessment of Engineered Cartilage Composition by Near Infrared Spectroscopy. Ann Biomed Eng, 44(3), pp. 680-692. United States. doi: 10.1007/s10439-015-1536-8

  • Ashinsky, B.G., Fishbein, K.W., Carter, E.M., Lin, P., Pleshko, N., Raggio, C.L., & Spencer, R.G. (2016). Multiparametric Classification of Skin from Osteogenesis Imperfecta Patients and Controls by Quantitative Magnetic Resonance Microimaging. PLoS One, 11(7), p. e0157891. United States. doi: 10.1371/journal.pone.0157891

  • Cheng, H.A., Drinnan, C.T., Pleshko, N., & Fisher, O.Z. (2015). Pseudotannins self-assembled into antioxidant complexes. Soft Matter, 11(39), pp. 7783-7791. England. doi: 10.1039/c5sm01224d

  • Boskey, A.L., Marino, J., Spevak, L., Pleshko, N., Doty, S., Carter, E.M., & Raggio, C.L. (2015). Are Changes in Composition in Response to Treatment of a Mouse Model of Osteogenesis Imperfecta Sex-dependent? Clin Orthop Relat Res, 473(8), pp. 2587-2598. United States. doi: 10.1007/s11999-015-4268-z

  • Hemmasizadeh, A., Tsamis, A., Cheheltani, R., Assari, S., D'Amore, A., Autieri, M., Kiani, M.F., Pleshko, N., Wagner, W.R., Watkins, S.C., Vorp, D., & Darvish, K. (2015). Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. J Mech Behav Biomed Mater, 47, pp. 12-20. Netherlands. doi: 10.1016/j.jmbbm.2015.03.004

  • O'Brien, M.P., Penmatsa, M., Palukuru, U., West, P., Yang, X.u., Bostrom, M.P.G., Freeman, T., & Pleshko, N. (2015). Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy. Cartilage, 6(3), pp. 174-184. United States. doi: 10.1177/1947603515572874

  • Padalkar, M.V. & Pleshko, N. (2015). Wavelength-dependent penetration depth of near infrared radiation into cartilage. Analyst, 140(7), pp. 2093-2100. England. doi: 10.1039/c4an01987c

  • Gollwitzer, H., Yang, X.u., Spevak, L., Lukashova, L., Nocon, A., Fields, K., Pleshko, N., Courtland, H.W., Bostrom, M.P., & Boskey, A.L. (2015). Fourier Transform Infrared Spectroscopic Imaging of Fracture Healing in the Normal Mouse. J Spectrosc (Hindawi), 2015. United States. doi: 10.1155/2015/659473

  • Caccese, N., Palukuru, U., Thakkar, P., McGoverin, C., Pleshko, N., Cheng, C., Solorio, L., Correa, D., Philips, L., McMillan, A., & Alsberg, E. (2014). FTIR imaging analysis of bioactive microsphere incorporated stem cell sheets for osteochondral defect repair. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2014-December. doi: 10.1109/NEBEC.2014.6972745

  • Khanarian, N.T., Boushell, M.K., Spalazzi, J.P., Pleshko, N., Boskey, A.L., & Lu, H.H. (2014). FTIR-I compositional mapping of the cartilage-to-bone interface as a function of tissue region and age. J Bone Miner Res, 29(12), pp. 2643-2652. United States. doi: 10.1002/jbmr.2284

  • Palukuru, U.P., McGoverin, C.M., & Pleshko, N. (2014). Assessment of hyaline cartilage matrix composition using near infrared spectroscopy. Matrix Biol, 38, pp. 3-11. Netherlands. doi: 10.1016/j.matbio.2014.07.007

  • Terajima, M., Perdivara, I., Sricholpech, M., Deguchi, Y., Pleshko, N., Tomer, K.B., & Yamauchi, M. (2014). Glycosylation and cross-linking in bone type I collagen. J Biol Chem, 289(33), pp. 22636-22647. United States. doi: 10.1074/jbc.M113.528513

  • Cheheltani, R., McGoverin, C.M., Rao, J., Vorp, D.A., Kiani, M.F., & Pleshko, N. (2014). Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta. Analyst, 139(12), pp. 3039-3047. England. doi: 10.1039/c3an02371k

  • Barbe, M.F., Adiga, R., Gordiienko, O., Pleshko, N., Selzer, M.E., & Krynska, B. (2014). Micro-computed tomography assessment of vertebral column defects in retinoic acid-induced rat model of myelomeningocele. Birth Defects Res a Clin Mol Teratol, 100(6), pp. 453-462. United States. doi: 10.1002/bdra.23254

  • Johnson, C.M., Pleshko, N., Achary, M., & Suri, R.P.S. (2014). Rapid and sensitive screening of 17β-estradiol estrogenicity using Fourier transform infrared imaging spectroscopy (FT-IRIS). Environ Sci Technol, 48(8), pp. 4581-4587. United States. doi: 10.1021/es5000676

  • Padalkar, M., McGoverin, C., Onigbanjo, Q., Spencer, R., Barbash, S., Kropf, E., & Pleshko, N. (2014). Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8926. doi: 10.1117/12.2047473

  • McGoverin, C.M., Lewis, K., Yang, X.u., Bostrom, M.P.G., & Pleshko, N. (2014). The contribution of bone and cartilage to the near-infrared spectrum of osteochondral tissue. Appl Spectrosc, 68(10), pp. 1168-1175. United States. doi: 10.1366/13-07327

  • Sahu, A., Saleheen, F., Oleksyuk, V., McGoverin, C., Pleshko, N., Torbati, A., Picone, J., Sorenmo, K., & Won, C.H. (2014). Characterization of mammary tumors using noninvasive tactile and hyperspectral sensors. IEEE Sensors Journal, 14(10), pp. 3337-3344. doi: 10.1109/JSEN.2014.2323215

  • Cheheltani, R., Rao, J., Vorp, D.A., Pleshko, N., & Kiani, M.F. (2013). Prediction of Elastin Degradation in Aorta Using a Novel Infrared Spectroscopic Methodology. CIRCULATION, 128(22). Retrieved from http://gateway.webofknowledge.com/

  • Cheheltani, R., McGoverin, C.M., Kiani, M., & Pleshko, N. (2013). Infrared spectroscopy to measure collagen and elastin in aorta using multivariate analysis. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 13-14. doi: 10.1109/NEBEC.2013.103

  • Hemmasizadeh, A., Cheheltani, R., Assari, S., Pleshko, N., & Darvish, K. (2013). Spatial variation in aorta composition and correlation with mechanical properties. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 94-95. doi: 10.1109/NEBEC.2013.140

  • Padalkar, M., McGoverin, C., Pleshko, N., Barbash, S., & Kropf, E. (2013). Near infrared spectroscopy differentiates ligament and tendon composition. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 66-67. doi: 10.1109/NEBEC.2013.121

  • Palukuru, U., Shockley, M., McGoverin, C., Glenn, P., Pleshko, N., Spencer, R., Frank, E., & Grodzinsky, A. (2013). Assessment of changes in engineered cartilage using infrared spectroscopy and mechanical analysis. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 86-87. doi: 10.1109/NEBEC.2013.54

  • Shockley, M., McGoverin, C., Palukuru, U., Glenn, P., Pleshko, N., & Spencer, R. (2013). Near infrared spectroscopy as a method for non-destructive monitoring of engineered cartilage growth. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 51-52. doi: 10.1109/NEBEC.2013.119

  • Padalkar, M.V., Spencer, R.G., & Pleshko, N. (2013). Near infrared spectroscopic evaluation of water in hyaline cartilage. Ann Biomed Eng, 41(11), pp. 2426-2436. United States. doi: 10.1007/s10439-013-0844-0

  • Sahu, A., Mcgoverin, C., Pleshko, N., Sorenmo, K., & Won, C.H. (2013). Hyperspectral imaging to discern malignant and benign canine mammary tumors. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8719. doi: 10.1117/12.2015836

  • Spencer, R.G. & Pleshko, N. (2013). How do statistical differences in matrix-sensitive magnetic resonance outcomes translate into clinical assignment rules? J Am Acad Orthop Surg, 21(7), pp. 438-439. United States. doi: 10.5435/JAAOS-21-07-438

  • Perdivara, I., Perera, L., Sricholpech, M., Terajima, M., Pleshko, N., Yamauchi, M., & Tomer, K.B. (2013). Unusual fragmentation pathways in collagen glycopeptides. J Am Soc Mass Spectrom, 24(7), pp. 1072-1081. United States. doi: 10.1007/s13361-013-0624-y

  • Hanifi, A., McGoverin, C., Ou, Y., Safadi, F., Spencer, R.G., & Pleshko, N. (2013). Differences in infrared spectroscopic data of connective tissues in transflectance and transmittance modes. Anal Chim Acta, 779, pp. 41-49. Netherlands. doi: 10.1016/j.aca.2013.03.053

  • Marino, J., Pleshko, N., Doty, S., Carter, E., Boskey, A., & Raggio, C. (2013). Switching from Alendronate to RANKL Blockade alters Bone Properties after 14 Weeks of Therapy in the oim/oim Mouse. JOURNAL of BONE and MINERAL RESEARCH, 28. Retrieved from http://gateway.webofknowledge.com/

  • Spalazzi, J.P., Boskey, A.L., Pleshko, N., & Lu, H.H. (2013). Quantitative mapping of matrix content and distribution across the ligament-to-bone insertion. PLoS One, 8(9), p. e74349. United States. doi: 10.1371/journal.pone.0074349

  • Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PLoS One, 8(5), p. e64822. United States. doi: 10.1371/journal.pone.0064822

  • Hanifi, A., Bi, X., Yang, X.u., Kavukcuoglu, B., Lin, P.C., DiCarlo, E., Spencer, R.G., Bostrom, M.P.G., & Pleshko, N. (2012). Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading. Am J Sports Med, 40(12), pp. 2853-2861. United States. doi: 10.1177/0363546512462009

  • Bargman, R., Posham, R., Boskey, A., Carter, E., DiCarlo, E., Verdelis, K., Raggio, C., & Pleshko, N. (2012). High- and low-dose OPG-Fc cause osteopetrosis-like changes in infant mice. Pediatr Res, 72(5), pp. 495-501. United States. doi: 10.1038/pr.2012.118

  • Hanifi, A., Richardson, J.B., Kuiper, J.H., Roberts, S., & Pleshko, N. (2012). Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis Cartilage, 20(9), pp. 988-996. England. doi: 10.1016/j.joca.2012.05.007

  • Masahiko, T., Damle, S., Penmatsa, M., West, P., Yang, X.u., Bostrom, M., Hidaka, C., Yamauchi, M., & Pleshko, N. (2012). Temporal changes in collagen cross-links in spontaneous articular cartilage repair. Cartilage, 3(3), pp. 278-287. United States. doi: 10.1177/1947603512437736

  • Kim, M., Erickson, I.E., Choudhury, M., Pleshko, N., & Mauck, R.L. (2012). Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels. J Mech Behav Biomed Mater, 11, pp. 92-101. Netherlands. doi: 10.1016/j.jmbbm.2012.03.006

  • Cheheltani, R., Wang, B., Sabri, A., Pleshko, N., & Kiani, M. (2012). Fourier transform infrared imaging spectroscopy of collagen deposition after myocardial infarction. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 305-306. doi: 10.1109/NEBC.2012.6207086

  • Johnson, C.M., Pleshko, N., Achary, M., & Suri, R.P. (2012). Development of a Fourier transform infrared imaging spectroscopic assay for screening estrogenic contaminants. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 57-58. doi: 10.1109/NEBC.2012.6206960

  • O'Brien, M.P., Penmatsa, M., Palukuru, U., West, P., Yang, X., Bostrom, M., Freeman, T., & Pleshko, N. (2012). Comparison of histological grading to Fourier transform infrared imaging analysis of cartilage repair tissue. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 372-373. doi: 10.1109/NEBC.2012.6207119

  • Padalkar, M., Spencer, R., & Pleshko, N. (2012). Near infrared spectroscopic evaluation of water in hyaline cartilage. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 370-371. doi: 10.1109/NEBC.2012.6207118

  • Ou, Y., Belcher, J.Y., Yingling, V.R., Safadi, F., & Pleshko, N. (2012). Compositional and mechanical properties of long bones of osteoactivin mutant mice. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 436-437. doi: 10.1109/NEBC.2012.6206928

  • Hanifi, A., Terajima, M., Yamauchi, M., & Pleshko, N. (2012). Comparison of spectroscopic and biochemical determination of collagen crosslinks in cartilage. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 41-42. doi: 10.1109/NEBC.2012.6206952

  • Kavukcuoglu, N.B., Li, Q., Pleshko, N., & Uitto, J. (2012). Connective tissue mineralization in Abcc6-/- mice, a model for pseudoxanthoma elasticum. Matrix Biol, 31(4), pp. 246-252. Netherlands. doi: 10.1016/j.matbio.2012.02.004

  • Cheheltani, R., Rosano, J.M., Wang, B., Sabri, A.K., Pleshko, N., & Kiani, M.F. (2012). Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction. J Biomed Opt, 17(5), p. 056014. United States. doi: 10.1117/1.JBO.17.5.056014

  • Reiter, D.A., Irrechukwu, O., Lin, P., Moghadam, S., Thaer, S.V., Pleshko, N., & Spencer, R.G. (2012). Improved MR-based characterization of engineered cartilage using multiexponential T2 relaxation and multivariate analysis. NMR Biomed, 25(3), pp. 476-488. England. doi: 10.1002/nbm.1804

  • Bargman, R., Posham, R., Boskey, A.L., DiCarlo, E., Raggio, C., & Pleshko, N. (2012). Comparable outcomes in fracture reduction and bone properties with RANKL inhibition and alendronate treatment in a mouse model of osteogenesis imperfecta. Osteoporos Int, 23(3), pp. 1141-1150. England. doi: 10.1007/s00198-011-1742-7

  • Pleshko, N., Grande, D.A., & Myers, K.R. (2012). Nanotechnology in orthopaedics. J Am Acad Orthop Surg, 20(1), pp. 60-62. United States. doi: 10.5435/JAAOS-20-01-060

  • Canuto, H.C., Fishbein, K.W., Huang, A., Doty, S.B., Herbert, R.A., Peckham, J., Pleshko, N., & Spencer, R.G. (2012). Characterization of skin abnormalities in a mouse model of osteogenesis imperfecta using high resolution magnetic resonance imaging and Fourier transform infrared imaging spectroscopy. NMR Biomed, 25(1), pp. 169-176. England. doi: 10.1002/nbm.1732

  • Kim, M., Kraft, J.J., Volk, A.C., Pugarelli, J., Pleshko, N., & Dodge, G.R. (2011). Characterization of a cartilage-like engineered biomass using a self-aggregating suspension culture model: molecular composition using FT-IRIS. J Orthop Res, 29(12), pp. 1881-1887. United States. doi: 10.1002/jor.21467

  • Reiter, D.A., Roque, R.A., Lin, P., Doty, S.B., Pleshko, N., & Spencer, R.G. (2011). Improved specificity of cartilage matrix evaluation using multiexponential transverse relaxation analysis applied to pathomimetically degraded cartilage. NMR Biomed, 24(10), pp. 1286-1294. England. doi: 10.1002/nbm.1690

  • Kavukcuoglu, N.B. & Pleshko, N. (2011). Infrared and Raman microscopy and imaging of biomaterials. In Comprehensive Biomaterials, 3 (pp. 365-378).

  • Mahmoodian, R., Leasure, J., Philip, P., Pleshko, N., Capaldi, F., & Siegler, S. (2011). Changes in mechanics and composition of human talar cartilage anlagen during fetal development. Osteoarthritis Cartilage, 19(10), pp. 1199-1209. England. doi: 10.1016/j.joca.2011.07.013

  • Li, Q., Kavukcuoglu, N.B., Pleshko, N., & Uitto, J. (2011). Element Composition Status and Mineral Deposits in the Abcc6(-/-) Mice, a Model for Pseudoxanthoma Elasticum. JOURNAL of INVESTIGATIVE DERMATOLOGY, 131, pp. S71-S71. Retrieved from http://gateway.webofknowledge.com/

  • Arteaga-Solis, E., Sui-Arteaga, L., Kim, M., Schaffler, M.B., Jepsen, K.J., Pleshko, N., & Ramirez, F. (2011). Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biol, 30(3), pp. 188-194. Netherlands. doi: 10.1016/j.matbio.2011.03.004

  • Reiter, D.A., Roque, R.A., Lin, P., Irrechukwu, O., Doty, S., Longo, D.L., Pleshko, N., & Spencer, R.G. (2011). Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis. Magn Reson Med, 65(2), pp. 377-384. United States. doi: 10.1002/mrm.22673

  • Irrechukwu, O.N., Lin, P., Fritton, K., Doty, S., Pleshko, N., & Spencer, R.G. (2011). Magnetic resonance studies of macromolecular content in engineered cartilage treated with pulsed low-intensity ultrasound. Tissue Eng Part A, 17(3-4), pp. 407-415. United States. doi: 10.1089/ten.TEA.2010.0187

  • Raghavan, M., Sahar, N.D., Wilson, R.H., Mycek, M.A., Pleshko, N., Kohn, D.H., & Morris, M.D. (2010). Polarized Raman spectroscopy of bone tissue: Watch the scattering. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7548. doi: 10.1117/12.841977

  • Colon, A., Parvizi, J., Pleshko, N., Williams, C.J., & Freeman, T.A. (2010). EXPRESSION PROFILING OF SKELETOGENIC-RELEVANT PATHWAYS REVEALS CONTRASTING PATHOGENETIC MECHANISMS IN MENISCAL RNA FROM OSTEOARTHRITIS VERSUS CHONDROCALCINOSIS PATIENTS. OSTEOARTHRITIS and CARTILAGE, 18, pp. S219-S219. doi: 10.1016/S1063-4584(10)60514-6

  • Baykal, D., Irrechukwu, O., Lin, P., Fritton, K., Spencer, R.G., & Pleshko, N. (2010). Nondestructive assessment of engineered cartilage constructs using near-infrared spectroscopy. Appl Spectrosc, 64(10), pp. 1160-1166. United States. doi: 10.1366/000370210792973604

  • Kim, M., Foo, L.i.F., Uggen, C., Lyman, S., Ryaby, J.T., Moynihan, D.P., Grande, D.A., Potter, H.G., & Pleshko, N. (2010). Evaluation of early osteochondral defect repair in a rabbit model utilizing fourier transform-infrared imaging spectroscopy, magnetic resonance imaging, and quantitative T2 mapping. Tissue Eng Part C Methods, 16(3), pp. 355-364. United States. doi: 10.1089/ten.TEC.2009.0020

  • Raghavan, M., Sahar, N.D., Wilson, R.H., Mycek, M., Pleshko, N., Kohn, D.H., & Morris, M.D. (2010). Quantitative polarized Raman spectroscopy in highly turbid bone tissue. J Biomed Opt, 15(3), p. 037001. United States. doi: 10.1117/1.3426310

  • Gurkan, I., Ranganathan, A., Yang, X., Horton, W.E., Todman, M., Huckle, J., Pleshko, N., & Spencer, R.G. (2010). Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment. Osteoarthritis Cartilage, 18(5), pp. 724-733. England. doi: 10.1016/j.joca.2010.01.006

  • Bargman, R., Huang, A., Boskey, A.L., Raggio, C., & Pleshko, N. (2010). RANKL inhibition improves bone properties in a mouse model of osteogenesis imperfecta. Connect Tissue Res, 51(2), pp. 123-131. England. doi: 10.3109/03008200903108472

  • Hawkins, J., Cifuentes, M., Pleshko, N.L., Ambia-Sobhan, H., & Shapses, S.A. (2010). Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not obese female rats (Journal of Nutrition (2010) 140, (31-37)). Journal of Nutrition, 140(4), p. 877. doi: 10.3945/jn.110.121111

  • Cheheltani, R., Rosano, J.M., Wang, B., Pleshko, N., & Kiani, M.F. (2010). Targeted VEGF Therapy Favorably Alters Collagen Deposition and Quality after Myocardial Infarction. FASEB JOURNAL, 24. Retrieved from http://gateway.webofknowledge.com/

  • Hawkins, J., Cifuentes, M., Pleshko, N.L., Ambia-Sobhan, H., & Shapses, S.A. (2010). Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not obese female rats. J Nutr, 140(1), pp. 31-37. United States. doi: 10.3945/jn.109.111450

  • Leasure, J., Mahmoodian, R., Siegler, S., Capaldi, F., & Pleshko, N. (2009). Fourier transform infrared spectroscopic assessment of changes in composition of proteoglycans and collagen in developing human fetal tarsal bones. ASME International Mechanical Engineering Congress and Exposition, Proceedings, 2, pp. 553-560. doi: 10.1115/IMECE2008-67862

  • Herman, B.C., Kundi, R., Yamanouchi, D., Kent, K.C., Liu, B., & Pleshko, N. (2009). Molecular analysis of arterial remodeling: a novel application of infrared imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7182. doi: 10.1117/12.809425

  • Raggio, C.L., Fishbein, K.W., Carter, E.M., Kim, M., Pleshko, N., & Spencer, R.G. (2008). Identification of Skin Abnormalities in Osteogenesis Imperfecta Patients by Magnetic Resonance Imaging-A Pilot Study. JOURNAL of BONE and MINERAL RESEARCH, 23, pp. S240-S240. Retrieved from http://gateway.webofknowledge.com/

  • Pearson, K.J., Baur, J.A., Lewis, K.N., Peshkin, L., Price, N.L., Labinskyy, N., Swindell, W.R., Kamara, D., Minor, R.K., Perez, E., Jamieson, H.A., Zhang, Y., Dunn, S.R., Sharma, K., Pleshko, N., Woollett, L.A., Csiszar, A., Ikeno, Y., Couteur, D.L.e., Elliott, P.J., Becker, K.G., Navas, P., Ingram, D.K., Wolf, N.S., Ungvari, Z., Sinclair, D.A., & Cabo, R.d.e. (2008). Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab, 8(2), pp. 157-168. United States. doi: 10.1016/j.cmet.2008.06.011

  • Millán, J.L., Narisawa, S., Lemire, I., Loisel, T.P., Boileau, G., Leonard, P., Gramatikova, S., Terkeltaub, R., Camacho, N.P., McKee, M.D., Crine, P., & Whyte, M.P. (2008). Enzyme replacement therapy for murine hypophosphatasia. J Bone Miner Res, 23(6), pp. 777-787. United States. doi: 10.1359/jbmr.071213

  • Zhang, H., Ricciardi, B.F., Yang, X.u., Shi, Y., Camacho, N.P., & Bostrom, M.G. (2008). Polymethylmethacrylate particles stimulate bone resorption of mature osteoclasts in vitro. Acta Orthop, 79(2), pp. 281-288. Sweden. doi: 10.1080/17453670710015166

  • Delos, D., Yang, X.u., Ricciardi, B.F., Myers, E.R., Bostrom, M.P.G., & Camacho, N.P. (2008). The effects of RANKL inhibition on fracture healing and bone strength in a mouse model of osteogenesis imperfecta. J Orthop Res, 26(2), pp. 153-164. United States. doi: 10.1002/jor.20469

  • Yang, X.u., Ricciardi, B.F., Hernandez-Soria, A., Shi, Y., Camacho, N.P., & Bostrom, M.P.G. (2007). Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. Bone, 41(6), pp. 928-936. United States. doi: 10.1016/j.bone.2007.07.022

  • Mendelsohn, R., Boskey, A.L., & Camacho, N.P. (2007). Infrared Microscopy and Imaging of Hard and Soft Tissues: Applications to Bone, Skin and Cartilage. In Spectrochemical Analysis Using Infrared Multichannel Detectors (pp. 234-260). doi: 10.1002/9780470988541.ch11

  • Zhang, H., Doty, S.B., Hughes, C., Dempster, D., & Camacho, N.P. (2007). Increased resorptive activity and accompanying morphological alterations in osteoclasts derived from the oim/oim mouse model of osteogenesis imperfecta. J Cell Biochem, 102(4), pp. 1011-1020. United States. doi: 10.1002/jcb.21337

  • Millan, J.L., Narisawa, S., Lemire, I., Loisel, T.P., Boileau, G., Leonard, P., McKee, M.D., Crine, P., Johnson, K., Terkeltaub, R., Camacho, N.P., & Whyte, M.P. (2007). Enzyme replacement therapy for murine hypophosphatasia. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S72-S72. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P. & Akhter, M.P. (2007). Mineral and matrix characteristics in mice with LRP5 G171V mutation. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S162-S163. Retrieved from http://gateway.webofknowledge.com/

  • Yadav, M.C., Narisawa, S., Johnson, K., Terkeltaub, R., Camacho, N.P., & Milian, J.L. (2007). Increased bone mineral density in transgenic mice over-expressing tissue-nonspecific alkaline phosphatase. JOURNAL of BONE and MINERAL RESEARCH, 22, pp. S66-S66. Retrieved from http://gateway.webofknowledge.com/

  • Miller, E., Delos, D., Baldini, T., Wright, T.M., & Camacho, N.P. (2007). Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone. Calcif Tissue Int, 81(3), pp. 206-214. United States. doi: 10.1007/s00223-007-9045-x

  • Cheng, C., Conte, E., Pleshko-Camacho, N., & Hidaka, C. (2007). Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix Biol, 26(7), pp. 541-553. Netherlands. doi: 10.1016/j.matbio.2007.05.006

  • Millan, J.L., Narisawa, S., Lemire, I., Loisel, T., Boileau, G., Leonard, P., McKee, M.D., Crine, P., Johnson, K., Terkeltaub, R., Camacho, N.P., & Whyte, M.P. (2007). Enzyme replacement therapy for murine hypophosphatasia. BONE, 40(6), pp. S127-S128. Retrieved from http://gateway.webofknowledge.com/

  • Fishbein, K.W., Canuto, H.C., Bajaj, P., Camacho, N.P., & Spencer, R.G. (2007). Optimal methods for the preservation of cartilage samples in MRI and correlative biochemical studies. Magn Reson Med, 57(5), pp. 866-873. United States. doi: 10.1002/mrm.21189

  • Boskey, A. & Camacho, N.P. (2007). FT-IR imaging of native and tissue-engineered bone and cartilage. Biomaterials, 28(15), pp. 2465-2478. Netherlands. doi: 10.1016/j.biomaterials.2006.11.043

  • Bi, X., Yang, X.u., Bostrom, M.P.G., Bartusik, D., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., & Camacho, N.P. (2007). Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. Anal Bioanal Chem, 387(5), pp. 1601-1612. Germany. doi: 10.1007/s00216-006-0910-7

  • Spencer, R.G., Calton, E.F., & Camacho, N.P. (2006). Statistical comparison of Fourier transform infrared spectra. J Biomed Opt, 11(6), p. 064023. United States. doi: 10.1117/1.2393231

  • Franco, G.E.L., Huang, A., Camacho, N.P., Stone, D.S., & Blank, R.D. (2006). Increased Young's modulus and hardness of Col1a2oim dentin. J Dent Res, 85(11), pp. 1032-1036. United States. doi: 10.1177/154405910608501111

  • Zhang, H., Doty, S., Antoniv, T., Labissiere, A., & Camacho, N.P. (2006). An in vitro calvarial-osteoblast-osteociast co-culture system to assess remodeling abnormalities in the oim/oim mouse model of OI. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S432-S432. Retrieved from http://gateway.webofknowledge.com/

  • Harmey, D., Johnson, K.A., Zelken, J., Camacho, N.P., Hoylaerts, M.F., Noda, M., Terkeltaub, R., & Millan, J.L. (2006). Elevated skeletal osteopontin contributes to the hypophosphatasia phenotype in Akp2-/- mice. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S12-S12. Retrieved from http://gateway.webofknowledge.com/

  • Zhu, J., Huang, A., Bi, X., Zhang, H., & Camacho, N.P. (2006). Quantification of osteoclastic resorption on bone slices by infrared imaging. JOURNAL of BONE and MINERAL RESEARCH, 21, pp. S212-S213. Retrieved from http://gateway.webofknowledge.com/

  • Harmey, D., Johnson, K.A., Zelken, J., Camacho, N.P., Hoylaerts, M.F., Noda, M., Terkeltaub, R., & Millán, J.L. (2006). Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res, 21(9), pp. 1377-1386. United States. doi: 10.1359/jbmr.060619

  • Bi, X., Yang, X.u., Bostrom, M.P.G., & Camacho, N.P. (2006). Fourier transform infrared imaging spectroscopy investigations in the pathogenesis and repair of cartilage. Biochim Biophys Acta, 1758(7), pp. 934-941. Netherlands. doi: 10.1016/j.bbamem.2006.05.014

  • Garimella, R., Bi, X., Anderson, H.C., & Camacho, N.P. (2006). Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: An FTIR imaging study. Bone, 38(6), pp. 811-817. United States. doi: 10.1016/j.bone.2005.11.027

  • Southern, D., Lutz, G., Bracilovic, A., West, P., Spevak, M., Camacho, N.P., & Doty, S. (2006). Histological and molecular structure characterization of annular collagen after intradiskal electrothermal annuloplasty. HSS J, 2(1), pp. 49-54. United States. doi: 10.1007/s11420-005-0126-y

  • Bi, X., Li, G., Doty, S.B., & Camacho, N.P. (2005). A novel method for determination of collagen orientation in cartilage by Fourier transform infrared imaging spectroscopy (FT-IRIS). Osteoarthritis Cartilage, 13(12), pp. 1050-1058. England. doi: 10.1016/j.joca.2005.07.008

  • Li, G., Thomson, M., Dicarlo, E., Yang, X.u., Nestor, B., Bostrom, M.P.G., & Camacho, N.P. (2005). A chemometric analysis for evaluation of early-stage cartilage degradation by infrared fiber-optic probe spectroscopy. Appl Spectrosc, 59(12), pp. 1527-1533. United States. doi: 10.1366/000370205775142593

  • Draper, E.R.C., Morris, M.D., Camacho, N.P., Matousek, P., Towrie, M., Parker, A.W., & Goodship, A.E. (2005). Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy. J Bone Miner Res, 20(11), pp. 1968-1972. United States. doi: 10.1359/JBMR.050710

  • Franco, G., Stone, D., Huang, A., Camacho, N.P., & Blank, R.D. (2005). Mechanical consequences of the Colla2(oim) mutation in mouse dentin. JOURNAL of BONE and MINERAL RESEARCH, 20(9), pp. S417-S417. Retrieved from http://gateway.webofknowledge.com/

  • Morris, M.D., Draper, E., Goodship, A.E., Matousek, P., Towrie, M., Parker, A.W., & Camacho, N.P. (2005). Picosecond time-gated Raman spectroscopy for transcutaneous evaluation of bone composition. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5693, pp. 344-350. doi: 10.1117/12.585457

  • Anderson, H.C., Harmey, D., Camacho, N.P., Garimella, R., Sipe, J.B., Tague, S., Bi, X., Johnson, K., Terkeltaub, R., & Millán, J.L. (2005). Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. Am J Pathol, 166(6), pp. 1711-1720. United States. doi: 10.1016/S0002-9440(10)62481-9

  • Franco, G.E.L., Huang, A., Camacho, N.P., & Blank, R.D. (2005). Dental phenotype of the col1a2(oim) mutation: DI is present in both homozygotes and heterozygotes. Bone, 36(6), pp. 1039-1046. United States. doi: 10.1016/j.bone.2005.03.004

  • Kim, M., Bi, X., Horton, W.E., Spencer, R.G., & Camacho, N.P. (2005). Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations. J Biomed Opt, 10(3), p. 031105. United States. doi: 10.1117/1.1922329

  • West, P.A., Torzilli, P.A., Chen, C., Lin, P., & Camacho, N.P. (2005). Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation. J Biomed Opt, 10(1), p. 14015. United States. doi: 10.1117/1.1854131

  • Misof, B.M., Roschger, P., Baldini, T., Raggio, C.L., Zraick, V., Root, L., Boskey, A.L., Klaushofer, K., Fratzl, P., & Camacho, N.P. (2005). Differential effects of alendronate treatment on bone from growing osteogenesis imperfecta and wild-type mouse. Bone, 36(1), pp. 150-158. United States. doi: 10.1016/j.bone.2004.10.006

  • Franco, G., Huang, A., Camacho, N.P., & Blank, R.D. (2004). Colla2(oim) mice express dentinogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S100-S100. Retrieved from http://gateway.webofknowledge.com/

  • Anderson, H.C., Harmey, D., Camacho, N.P., Garimella, R., Sipe, J.B., Tague, S., Terkeltaub, R., & Millan, J.L. (2004). Hypornineralization of tibia in nucleoside triphosphate pyrophosphohydrolase (NPP1) deficient mice. JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S61-S61. Retrieved from http://gateway.webofknowledge.com/

  • Zhang, H., Hughes, C., Raggio, C., Dempster, D.W., & Camacho, N.P. (2004). Increased early resorption activity and alterations of morphology in osteoclasts derived from the oim/oim mouse model of osteogenesis imperfecta (OI). JOURNAL of BONE and MINERAL RESEARCH, 19, pp. S330-S330. Retrieved from http://gateway.webofknowledge.com/

  • Garimella, R., Bi, X., Camacho, N., Sipe, J.B., & Anderson, H.C. (2004). Primary culture of rat growth plate chondrocytes: an in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization. Bone, 34(6), pp. 961-970. United States. doi: 10.1016/j.bone.2004.02.010

  • West, P.A., Bostrom, M., Torzilli, P.A., & Camacho, N.P. (2004). Fourier transform infrared spectral analysis of degenerative cartilage: an infrared fiber optic probe and imaging study. Appl Spectrosc, 58(4), pp. 376-381. United States. doi: 10.1366/000370204773580194

  • Anderson, H.C., Sipe, J.B., Hessle, L., Dhanyamraju, R., Atti, E., Camacho, N.P., Millán, J.L., & Dhamyamraju, R. (2004). Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol, 164(3), pp. 841-847. United States. doi: 10.1016/s0002-9440(10)63172-0

  • Quenzer, J., Boachie-Adjei, K., Hao, A., Dunstan, C., Raggio, C.L., & Camacho, N.P. (2003). Treatment of OIM mice with osteoprotegerin. JOURNAL of BONE and MINERAL RESEARCH, 18, pp. S33-S33. Retrieved from http://gateway.webofknowledge.com/

  • Ling, S.M., Bang, D., Camacho, N.P., Yang, X., & Spencer, R.G. (2003). Micro-computed tomographic assessment of bone quality in an animal model of arthritis and unloading. ARTHRITIS and RHEUMATISM, 48(9), pp. S491-S491. Retrieved from http://gateway.webofknowledge.com/

  • Bonewald, L.F., Harris, S.E., Rosser, J., Dallas, M.R., Dallas, S.L., Camacho, N.P., Boyan, B., & Boskey, A. (2003). von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation. Calcif Tissue Int, 72(5), pp. 537-547. United States. doi: 10.1007/s00223-002-1057-y

  • Camacho, N.P., Carroll, P., & Raggio, C.L. (2003). Fourier transform infrared imaging spectroscopy (FT-IRIS) of mineralization in bisphosphonate-treated oim/oim mice. Calcif Tissue Int, 72(5), pp. 604-609. United States. doi: 10.1007/s00223-002-1038-1

  • McCarthy, E.A., Camacho, N.P., Raggio, C.L., Lawrence, L., Rahman, M., Garcia, R., & Hendricks-Munoz, K. (2003). Pilot study of in utero treatment of osteogenesis imperfecta (OI) with alendronate: Feasibility demonstrated in wildtype mouse model. PEDIATRIC RESEARCH, 53(4), pp. 53A-54A. Retrieved from http://gateway.webofknowledge.com/

  • Sims, T.J., Miles, C.A., Bailey, A.J., & Camacho, N.P. (2003). Properties of collagen in OIM mouse tissues. Connect Tissue Res, 44 Suppl 1, pp. 202-205. England. Retrieved from https://www.ncbi.nlm.nih.gov/

  • McCarthy, E.A., Raggio, C.L., Hossack, M.D., Miller, E.A., Jain, S., Boskey, A.L., & Camacho, N.P. (2002). Alendronate treatment for infants with osteogenesis imperfecta: demonstration of efficacy in a mouse model. Pediatr Res, 52(5), pp. 660-670. United States. doi: 10.1203/00006450-200211000-00010

  • McCarthy, E.A., Raggio, C.L., Hossack, M.D., Miller, E.A., Jain, S., Boskey, A.L., & Camacho, N.P. (2002). Alendronate treatment for infants with osteogenesis imperfecta: Demonstration of efficacy in a mouse model. Pediatric Research, 52(5), pp. 660-670. doi: 10.1203/00006450-200211000-00010

  • Miles, C.A., Sims, T.J., Camacho, N.P., & Bailey, A.J. (2002). The role of the alpha2 chain in the stabilization of the collagen type I heterotrimer: a study of the type I homotrimer in oim mouse tissues. J Mol Biol, 321(5), pp. 797-805. Netherlands. doi: 10.1016/s0022-2836(02)00703-9

  • Aparicio, S., Doty, S.B., Camacho, N.P., Paschalis, E.P., Spevak, L., Mendelsohn, R., & Boskey, A.L. (2002). Optimal methods for processing mineralized tissues for Fourier transform infrared microspectroscopy. Calcif Tissue Int, 70(5), pp. 422-429. United States. doi: 10.1007/s00223-001-1016-z

  • Hsu, H.H.T., Camacho, N.C., Tawfik, O., & Sun, F. (2002). Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification. Atherosclerosis, 161(1), pp. 85-94. Ireland. doi: 10.1016/s0021-9150(01)00623-2

  • Camacho, N.P., West, P., Griffith, M.H., Warren, R.F., & Hidaka, C. (2001). FT-IR imaging spectroscopy of genetically modified bovine chondrocytes. Materials Science and Engineering C, 17(1-2), pp. 3-9. doi: 10.1016/S0928-4931(01)00326-5

  • Patani, A.N., Pincavage, A., Bankston, J., Camacho, N.P., & Blank, R.D. (2001). Use of representational difference analysis to identify candidate RFLPs linked to modifiers of the murine Cola2(oim/oim) osteogenesis imperfecta phenotype. JOURNAL of BONE and MINERAL RESEARCH, 16, pp. S304-S304. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Tivol, W., Buttle, K., Raggio, C.L., Doty, S.B., & Landis, W.J. (2001). Comparison of mineral characteristics in oim/oim mice and human osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 16, pp. S422-S422. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Raggio, C.L., Doty, S.B., Root, L., Zraick, V., Ilg, W.A., Toledano, T.R., & Boskey, A.L. (2001). A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta. Calcif Tissue Int, 69(2), pp. 94-101. United States. doi: 10.1007/s002230010045

  • Hsu, H., Camacho, N.P., Tawfik, O., & Sun, F. (2001). Effects of high cholesterol feeding on arterial and vesicle calcification using rabbit as a model. BONE, 28(5), pp. S101-S102. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., West, P., Torzilli, P.A., & Mendelsohn, R. (2001). FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. Biopolymers - Biospectroscopy Section, 62(1), pp. 1-8. doi: 10.1002/1097-0282(2001)62:13.0.CO;2-O

  • Camacho, N.P., West, P., Torzilli, P.A., & Mendelsohn, R. (2001). FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. Biopolymers, 62(1), pp. 1-8. United States. doi: 10.1002/1097-0282(2001)62:13.0.CO;2-O

  • Hsu, H.H., Camacho, N.P., Sun, F., Tawfik, O., & Aono, H. (2000). Isolation of calcifiable vesicles from aortas of rabbits fed with high cholesterol diets. Atherosclerosis, 153(2), pp. 337-348. Ireland. doi: 10.1016/s0021-9150(00)00425-1

  • Camacho, N.P., Raggio, C.L., & Blank, R.D. (2000). Osteogenesis imperfecta. Current Opinion in Orthopaedics, 11(5), pp. 341-346. doi: 10.1097/00001433-200010000-00003

  • Camacho, N.P., McCarthy, E.A., Jain, S., Gupta, R., Wurzburger, R., Raggio, C.L., & Blank, R.D. (2000). Emergence of fracture-resistant Cola2(oim/oim) mice. JOURNAL of BONE and MINERAL RESEARCH, 15, pp. S484-S484. Retrieved from http://gateway.webofknowledge.com/

  • McCarthy, E.A., Hossack, M., Miller, E.A., Zraick, V., Jain, M., Boacci, O., Raggio, C., & Camacho, N.P. (2000). Osteogenesis imperfecta: Alendronate reduces fractures and corrects spinal curvature in infant mouse model. PEDIATRIC RESEARCH, 47(4), pp. 415A-415A. Retrieved from http://gateway.webofknowledge.com/

  • Brown, C.W., Bu, D., Camacho, N.P., & Mendelsohn, R. (2000). Mechanisms for the conversion of hyperspectral images to chemical images. Proceedings of SPIE - the International Society for Optical Engineering, 3920, pp. 118-128.

  • Camacho, N.P., Rinnerthaler, S., Paschalis, E.P., Mendelsohn, R., Boskey, A.L., & Fratzl, P. (1999). Complementary information on bone ultrastructure from scanning small angle X-ray scattering and Fourier-transform infrared microspectroscopy. Bone, 25(3), pp. 287-293. United States. doi: 10.1016/s8756-3282(99)00165-9

  • Bostrom, M., Hossack, M.D., Miller, E.A., Gamradt, S.C., & Camacho, N.P. (1999). The effect of alendronate in a new mouse femur fracture model. JOURNAL of BONE and MINERAL RESEARCH, 14, pp. S208-S208. Retrieved from http://gateway.webofknowledge.com/

  • Hsu, H.H. & Camacho, N.P. (1999). Isolation of calcifiable vesicles from human atherosclerotic aortas. Atherosclerosis, 143(2), pp. 353-362. Ireland. doi: 10.1016/s0021-9150(98)00322-0

  • McCarthy, E.A., Hossack, M., Miller, E.A., Raggio, C., & Camacho, N.P. (1999). Alendronate reduces fractures and corrects spinal curvature in infant mouse model of osteogenesis imperfecta. PEDIATRIC RESEARCH, 45(4), pp. 210A-210A. doi: 10.1203/00006450-199904020-01251

  • Camacho, N.P., Hou, L., Toledano, T.R., Ilg, W.A., Brayton, C.F., Raggio, C.L., Root, L., & Boskey, A.L. (1999). The material basis for reduced mechanical properties in oim mice bones. J Bone Miner Res, 14(2), pp. 264-272. United States. doi: 10.1359/jbmr.1999.14.2.264

  • Hsu, H.H., Camacho, N.P., & Anderson, H.C. (1999). Further characterization of ATP-initiated calcification by matrix vesicles isolated from rachitic rat cartilage. Membrane perturbation by detergents and deposition of calcium pyrophosphate by rachitic matrix vesicles. Biochim Biophys Acta, 1416(1-2), pp. 320-332. Netherlands. doi: 10.1016/s0005-2736(98)00235-1

  • Blank, R.D., Raggio, C.L., Giampietro, P.F., & Camacho, N.P. (1999). A genomic approach to scoliosis pathogenesis. Lupus, 8(5), pp. 356-360. England. doi: 10.1177/096120339900800505

  • Bostrom, M.P. & Camacho, N.P. (1998). Potential role of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res(355 Suppl), pp. S274-S282. United States. doi: 10.1097/00003086-199810001-00028

  • Derfus, B., Kranendonk, S., Camacho, N., Mandel, N., Kushnaryov, V., Lynch, K., & Ryan, L. (1998). Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro. Calcif Tissue Int, 63(3), pp. 258-262. United States. doi: 10.1007/s002239900523

  • Camacho, N.P., Dow, D., Toledano, T.R., Buckmeyer, J.K., Gertner, J.M., Brayton, C.F., Raggio, C.L., Root, L., & Boskey, A.L. (1998). Identification of the oim mutation by dye terminator chemistry combined with automated direct DNA sequencing. J Orthop Res, 16(1), pp. 38-42. United States. doi: 10.1002/jor.1100160107

  • Pienkowski, D., Doers, T.M., Monier-Faugere, M.C., Geng, Z., Camacho, N.P., Boskey, A.L., & Malluche, H.H. (1997). Calcitonin alters bone quality in beagle dogs. J Bone Miner Res, 12(11), pp. 1936-1943. United States. doi: 10.1359/jbmr.1997.12.11.1936

  • Camacho, N.P., Brayton, C.F., Buckmeyer, J., Raggio, C.L., Root, L., Toledano, T., & Boskey, A.L. (1997). Evaluation of alendronate for treatment in an animal model of osteogenesis imperfecta. JOURNAL of BONE and MINERAL RESEARCH, 12, pp. F654-F654. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Hou, L., Schenkel, B., Raggio, C.L., & Boskey, A.L. (1997). Abnormal mineralization reduces bone mechanical properties in the oim mouse. JOURNAL of DENTAL RESEARCH, 76, pp. 2189-2189. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Landis, W.J., & Boskey, A.L. (1996). Mineral changes in a mouse model of osteogenesis imperfecta detected by fourier transform infrared microscopy. Connective Tissue Research, 35(1-4), pp. 313-319.

  • Derfus, B.A., Kurtin, S.M., Camacho, N.P., Kurup, I., & Ryan, L.M. (1996). Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. Connective Tissue Research, 35(1-4), pp. 391-396.

  • Bonewald, L.F., Dallas, S., Qiao, M., Camacho, N.P., Boyan, B., & Boskey, A. (1996). Comparison of mineralized matrix of fetal rat calvarial cells and MC-3T3-E1 osteoblast-like cells by Fourier transform infrared spectroscopy (FT-IR). JOURNAL of BONE and MINERAL RESEARCH, 11, pp. S333-S333. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Brayton, C., Gertner, J., Raggio, C.L., Root, L., & Boskey, A.L. (1996). Effect of a third generation bisphosphonate on bone properties in the oim mouse. JOURNAL of BONE and MINERAL RESEARCH, 11, pp. M613-M613. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P. (1996). Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora (vol 17, pg 271, 1995). BONE, 19(1), pp. 77-77. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P. & et, A. (1996). Erratum: Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora (Bone (1995) 17 (271-278)). Bone, 19(1), p. 77. doi: 10.1016/8756-3282(96)00104-4

  • Derfus, B.A., Kurtin, S.M., Camacho, N.P., Kurup, I., & Ryan, L.M. (1996). Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. Connect Tissue Res, 35(1-4), pp. 337-342. England. doi: 10.3109/03008209609029209

  • Camacho, N.P., Raggio, C.L., Brayton, C., & Boskey, A.L. (1996). Analysis of dentin in osteogenesis imperfecta. JOURNAL of DENTAL RESEARCH, 75, pp. 212-212. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Landis, W.J., & Boskey, A.L. (1996). Mineral changes in a mouse model of osteogenesis imperfecta detected by Fourier transform infrared microscopy. Connect Tissue Res, 35(1-4), pp. 259-265. England. doi: 10.3109/03008209609029199

  • Gadaleta, S.J., Camacho, N.P., Mendelsohn, R., & Boskey, A.L. (1996). Fourier transform infrared microscopy of calcified turkey leg tendon. Calcif Tissue Int, 58(1), pp. 17-23. United States. doi: 10.1007/BF02509541

  • Camacho, N.P., Rimnac, C.M., Meyer, R.A., Doty, S., & Boskey, A.L. (1995). Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora. Bone, 17(3), pp. 271-278. United States. doi: 10.1016/8756-3282(95)00210-5

  • CAMACHO, N.P., MENDELSOHN, R., DICARLO, E., & BOSKEY, A.L. (1995). CHANGES IN OSTEOPOROTIC BONE-MINERAL WITH NAF TREATMENT AS DETECTED BY FOURIER-TRANSFORM INFRARED MICROSCOPY. JOURNAL of BONE and MINERAL RESEARCH, 10, pp. S355-S355. Retrieved from http://gateway.webofknowledge.com/

  • Gadaleta, S.J., Mendelsohn, R., Paschalis, E.L., Camacho, N.P., Betts, F., & Boskey, A.L. (1995). Fourier transform infrared spectroscopy of synthetic and biological apatites - A review. MINERAL SCALE FORMATION and INHIBITION, pp. 283-294. Retrieved from http://gateway.webofknowledge.com/

  • Camacho, N.P., Smith, D.R., Goldman, A., Schneider, B., Green, D., Young, P.R., & Berman, H.M. (1993). Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry, 32(34), pp. 8749-8757. United States. doi: 10.1021/bi00085a005

  • Boskey, A.L., Camacho, N.P., Mendelsohn, R., Doty, S.B., & Binderman, I. (1992). FT-IR microscopic mappings of early mineralization in chick limb bud mesenchymal cell cultures. Calcif Tissue Int, 51(6), pp. 443-448. United States. doi: 10.1007/BF00296678

  • Pleshko, N.L., Boskey, A.L., & Mendelsohn, R. (1992). An infrared study of the interaction of polymethyl methacrylate with the protein and mineral components of bone. J Histochem Cytochem, 40(9), pp. 1413-1417. United States. doi: 10.1177/40.9.1506677

  • Pleshko, N.L., Boskey, A.L., & Mendelsohn, R. (1992). An FT-IR microscopic investigation of the effects of tissue preservation on bone. Calcif Tissue Int, 51(1), pp. 72-77. United States. doi: 10.1007/BF00296221

  • BOSKEY, A.L., PLESHKO, N., DOTY, S.B., & MENDELSOHN, R. (1992). APPLICATIONS OF FOURIER-TRANSFORM INFRARED (FT-IR) MICROSCOPY TO THE STUDY OF MINERALIZATION IN BONE AND CARTILAGE. CELLS and MATERIALS, 2(3), pp. 209-220. Retrieved from http://gateway.webofknowledge.com/

  • Pleshko, N., Boskey, A., & Mendelsohn, R. (1991). Novel infrared spectroscopic method for the determination of crystallinity of hydroxyapatite minerals. Biophys J, 60(4), pp. 786-793. United States. doi: 10.1016/S0006-3495(91)82113-0

  • Mendelsohn, R., Hassankhani, A., Pleshko, N., DiCarlo, E., & Boskey, A. (1989). FT-IR microscopy of biomineralization at 20µ spatial resolution. Proceedings of SPIE - the International Society for Optical Engineering, 1145, pp. 403-404. doi: 10.1117/12.969521