Biography

Michel A Lemay, PhD is a Professor in the Department of Bioengineering at Temple University. His research group focuses on understanding the functioning and contribution of the spinal circuitry to the control of locomotion, and how this circuitry can be re-engaged for rehabilitation purposes following injury. Dr.Lemay's group uses a number of tools to activate and probe the spinal circuitry, techniques ranging from cellular delivery of neurotrophic factors to electrical stimulation of the spinal cord or its afferent feedback to locomotor re-training and multiunit recording of interneuronal activity during locomotion. Prior to coming to Temple University, Dr. Lemay was a Professor in the Department of Neurobiology and Anatomy at Drexel University College of Medicine, and a Principal Investigator in the Spinal Cord Research Center at this institution. Dr. Lemay received his PhD and MS in Biomedical Engineering from Case Western Reserve University, and trained as a post-doctoral fellow under Drs. Neville Hogan and Emilio Bizzi at the Massachusetts Institute of Technology.

Research Interests

  • Neural Engineering
  • Spinal Cord Role in Movement
  • Spinal Cord Injury & Plasticity
  • Spinal Circuitry
  • Biomechanics
  • Neuroprosthesis

Selected Publications

  • Vahedipour, A., Short, M.R., Timnak, A., Maghsoudi, O.H., Hallowell, T., Gerstenhaber, J., Cappellari, O., Lemay, M., & Spence, A.J. (2021). A versatile system for neuromuscular stimulation and recording in the mouse model using a lightweight magnetically coupled headmount. Journal of Neuroscience Methods, 362. doi: 10.1016/j.jneumeth.2021.109319

  • Moukarzel, G., Lemay, M.A., & Spence, A.J. (2021). A MATLAB application for automated H-Reflex measurements and analyses. Biomedical Signal Processing and Control, 66. doi: 10.1016/j.bspc.2021.102448

  • Marchionne, F., Krupka, A.J., Smith, G.M., & Lemay, M.A. (2020). Intrathecal delivery of BDNF into the lumbar cistern re-engages locomotor stepping after spinal cord injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28(11), pp. 2459-2467. doi: 10.1109/TNSRE.2020.3027393

  • Eisdorfer, J.T., Smit, R.D., Keefe, K.M., Lemay, M.A., Smith, G.M., & Spence, A.J. (2020). Epidural Electrical Stimulation: A Review of Plasticity Mechanisms That Are Hypothesized to Underlie Enhanced Recovery From Spinal Cord Injury With Stimulation. Frontiers in Molecular Neuroscience, 13. doi: 10.3389/fnmol.2020.00163

  • Higgin, D., Krupka, A., Maghsoudi, O.H., Klishko, A.N., Nichols, T.R., Lyle, M.A., Prilutsky, B.I., & Lemay, M.A. (2020). Adaptation to slope in locomotor-trained spinal cats with intact and self-reinnervated lateral gastrocnemius and soleus muscles. Journal of Neurophysiology, 123(1), pp. 70-89. doi: 10.1152/jn.00018.2019

  • Tiwari, E., Barbe, M.F., Lemay, M.A., Salvadeo, D.M., Wood, M.W., Mazzei, M., Musser, L.V., Delalic, Z.J., Braverman, A.S., & Ruggieri, M.R. (2019). Acute bladder decentralization in hound dogs: Preliminary results of effects on hypogastric nerve electroneurograms and detrusor pressure responses to spinal root and hypogastric nerve stimulation. PLoS ONE, 14(4). doi: 10.1371/journal.pone.0215036

  • Tom, B., Witko, J., Lemay, M., & Singh, A. (2018). Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury. Experimental Brain Research, 236(11), pp. 3077-3084. doi: 10.1007/s00221-018-5344-x

  • Salako, K., Lakshmanan, S., McMahon, C., & Lemay, M. (2018). Analysis of the mammalian central pattern generator through the characterization of lumbar interneuronal activity. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257037

  • Marchionne, F., Krupka, A.J., & Lemay, M.A. (2017). Effects of chronic intrathecal infusion of BDNF on interneuronal activity in a large animal model of spinal cord injury. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257035

  • Krupka, A.J., Fischer, I., & Lemay, M.A. (2017). Transplants of Neurotrophin-Producing Autologous Fibroblasts Promote Recovery of Treadmill Stepping in the Acute, Sub-Chronic, and Chronic Spinal Cat. Journal of Neurotrauma, 34(10), pp. 1858-1872. doi: 10.1089/neu.2016.4559

  • Côté, M.P., Murray, M., & Lemay, M.A. (2017). Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure. Journal of Neurotrauma, 34(10), pp. 1841-1857. doi: 10.1089/neu.2016.4577

  • Dimiskovski, M., Scheinfield, R., Higgin, D., Krupka, A., & Lemay, M.A. (2017). Characterization and validation of a split belt treadmill for measuring hindlimb ground-reaction forces in able-bodied and spinalized felines. Journal of Neuroscience Methods, 278, pp. 65-75. doi: 10.1016/j.jneumeth.2017.01.002

  • Grove, M., Kim, H., Santerre, M., Krupka, A.J., Han, S.B., Zhai, J., Cho, J.Y., Park, R., Harris, M., Kim, S., Sawaya, B.E., Kang, S.H., Barbe, M.F., Cho, S.H., Lemay, M.A., & Son, Y.J. (2017). YAP/TAZ initiate and maintain schwann cell myelination. ELife, 6. doi: 10.7554/eLife.20982

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2016). A Neuromechanical Model of Spinal Control of Locomotion. In Neuromechanical Modeling of Posture and Locomotion (pp. 21-65). Springer New York. doi: 10.1007/978-1-4939-3267-2_2

  • Lemay, M. & Giszter, S.F. (2015). Intraspinal Stimulation. In Encyclopedia of Computational Neuroscience (pp. 1448-1453). Springer New York. doi: 10.1007/978-1-4614-6675-8_594

  • Lemay, M. (2015). Spinal Interfaces: Overview. In Encyclopedia of Computational Neuroscience (pp. 104-108). Springer New York. doi: 10.1007/978-1-4614-6675-8_785

  • Ollivier-Lanvin, K., Fischer, I., Tom, V., Houlé, J.D., & Lemay, M.A. (2015). Either brain-derived neurotrophic factor or neurotrophin-3 only neurotrophin-producing grafts promote locomotor recovery in untrained spinalized cats. Neurorehabilitation and Neural Repair, 29(1), pp. 90-100. doi: 10.1177/1545968314532834

  • Xu, C., Klaw, M.C., Lemay, M.A., Baas, P.W., & Tom, V.J. (2015). Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury. Experimental Neurology, 263, pp. 172-176. doi: 10.1016/j.expneurol.2014.10.013

  • Bonner, J.F., Connors, T.M., Silverman, W.F., Kowalski, D.P., Lemay, M.A., & Fischer, I. (2013). Grafted Neural Progenitors Integrate and Restore Synaptic Activity across the Injured Spinal Cord (vol 31, pg 4675, 2011). JOURNAL of NEUROSCIENCE, 33(15), pp. 6705-6705. doi: 10.1523/JNEUROSCI.1003-13.2013

  • Tom, V.J., Sandrow-Feinberg, H.R., Miller, K., Domitrovich, C., Bouyer, J., Zhukareva, V., Klaw, M.C., Lemay, M.A., & Houlé, J.D. (2013). Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site. Experimental Neurology, 239(1), pp. 91-100. doi: 10.1016/j.expneurol.2012.09.011

  • Côté, M.P., Detloff, M.R., Wade, R.E., Lemay, M.A., & Houlé, J.D. (2012). Plasticity in ascending long propriospinal and descending supraspinal pathways in chronic cervical spinal cord injured rats. Frontiers in Physiology, 3 AUG. doi: 10.3389/fphys.2012.00330

  • Markin, S.N., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2012). Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: A comparison study. Journal of Neurophysiology, 107(8), pp. 2057-2071. doi: 10.1152/jn.00865.2011

  • Singh, A., Balasubramanian, S., Murray, M., Lemay, M., & Houle, J. (2011). Role of spared pathways in locomotor recovery after body-weight-supported treadmill training in contused rats. Journal of Neurotrauma, 28(12), pp. 2405-2416. doi: 10.1089/neu.2010.1660

  • Auyong, N., Ollivier-Lanvin, K., & Lemay, M.A. (2011). Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats. Journal of Neurophysiology, 106(4), pp. 1943-1953. doi: 10.1152/jn.00258.2011

  • Ollivier-Lanvin, K., Krupka, A.J., Yong, N.A., Miller, K., Prilutsky, B.I., & Lemay, M.A. (2011). Electrical stimulation of the sural cutaneous afferent nerve controls the amplitude and onset of the swing phase of locomotion in the spinal cat. Journal of Neurophysiology, 105(5), pp. 2297-2308. doi: 10.1152/jn.00385.2010

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., McCrea, D.A., & Rybak, I.A. (2011). Modeling the CPG-based Control of Cat Hindlimb Movement During Locomotion. FASEB JOURNAL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Bonner, J.F., Connors, T.M., Silverman, W.F., Kowalski, D.P., Lemay, M.A., & Fischer, I. (2011). Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord. Journal of Neuroscience, 31(12), pp. 4675-4686. doi: 10.1523/JNEUROSCI.4130-10.2011

  • AuYong, N., Ollivier-Lanvin, K., & Lemay, M.A. (2011). Preferred locomotor phase of activity of lumbar interneurons during air-stepping in subchronic spinal cats. Journal of Neurophysiology, 105(3), pp. 1011-1022. doi: 10.1152/jn.00523.2010

  • Côté, M.P., Azzam, G.A., Lemay, M.A., Zhukareva, V., & Houlé, J.D. (2011). Activity-dependent increase in neurotrophic factors is associated with an enhanced modulation of spinal reflexes after spinal cord injury. Journal of Neurotrauma, 28(2), pp. 299-309. doi: 10.1089/neu.2010.1594

  • Côté, M.P., Hanna, A., Lemay, M.A., Ollivier-Lanvin, K., Santi, L., Miller, K., Monaghan, R., & Houlé, J.D. (2010). Peripheral nerve grafts after cervical spinal cord injury in adult cats. Experimental Neurology, 225(1), pp. 173-182. doi: 10.1016/j.expneurol.2010.06.011

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2010). Afferent control of locomotor CPG: Insights from a simple neuromechanical model. Annals of the New York Academy of Sciences, 1198, pp. 21-34. doi: 10.1111/j.1749-6632.2010.05435.x

  • Ollivier-Lanvin, K., Keeler, B.E., Siegfried, R., Houlé, J.D., & Lemay, M.A. (2010). Proprioceptive neuropathy affects normalization of the H-reflex by exercise after spinal cord injury. Experimental Neurology, 221(1), pp. 198-205. doi: 10.1016/j.expneurol.2009.10.023

  • Houle, J.D., Amin, A., Cote, M.P., Lemay, M., Miller, K., Sandrow, H., Santi, L., Shumsky, J., & Tom, V. (2010). Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. Journal of Visualized Experiments.(33). doi: 10.3791/1324

  • Tom, V.J., Sandrow-Feinberg, H.R., Miller, K., Santi, L., Connors, T., Lemay, M.A., & Houlé, J.D. (2009). Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord. Journal of Neuroscience, 29(47), pp. 14881-14890. doi: 10.1523/JNEUROSCI.3641-09.2009

  • Ollivier-Lanvin, K., Lemay, M.A., Tessler, A., & Burns, A.S. (2009). Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury. Journal of Applied Physiology, 107(4), pp. 1190-1194. doi: 10.1152/japplphysiol.00282.2009

  • Lemay, M.A., Grasse, D., & Grill, W.M. (2009). Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 17(4), pp. 379-389. doi: 10.1109/TNSRE.2009.2023295

  • Boyce, V.S. & Lemay, M.A. (2009). Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin-treated chronic spinal cats. Journal of Neurophysiology, 101(3), pp. 1309-1320. doi: 10.1152/jn.00034.2008

  • Lemay, M.A., Bhowmik-Stoker, M., McConnell, G.C., & Grill, W.M. (2007). Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb. Journal of Biomechanics, 40(16), pp. 3679-3687. doi: 10.1016/j.jbiomech.2007.06.021

  • Boyce, V.S., Tumolo, M., Fischer, I., Murray, M., & Lemay, M.A. (2007). Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. Journal of Neurophysiology, 98(4), pp. 1988-1996. doi: 10.1152/jn.00391.2007

  • Burns, A.S., Boyce, V.S., Tessler, A., & Lemay, M.A. (2007). Fibrillation potentials following spinal cord injury: Improvement with neurotrophins and exercise. Muscle and Nerve, 35(5), pp. 607-613. doi: 10.1002/mus.20738

  • Boyce, V.S. & Lemay, M.A. (2005). Proportions of endpoint force pattern types obtained via intraspinal micro stimulation in chronically spinalized cats are dependent on sensorimotor training. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, pp. 473-474. doi: 10.1109/CNE.2005.1419662

  • Silverman, J., Garnett, N.L., Giszter, S.F., Heckman, C.J., Kulpa-Eddy, J.A., Lemay, M.A., Perry, C.K., & Pinter, M. (2005). Decerebrate mammalian preparations: Unalleviated or fully alleviated pain? A review and opinion. Contemporary Topics in Laboratory Animal Science, 44(4), pp. 34-36.

  • Lemay, M.A., Boyce, V.S., Tumolo, M.A., Murray, M., Fischer, I., & Burns, A.S. (2005). Neurotrophic factors promote locomotor recovery and changes in muscle electromyography in chronically spinalized animals. FASEB JOURNAL, 19(5), pp. A1649-A1649. Retrieved from http://gateway.webofknowledge.com/

  • Burns, A.S., Lemay, M.A., & Tessler, A. (2005). Abnormal spontaneous potentials in distal muscles in animal models of spinal cord injury. Muscle and Nerve, 31(1), pp. 46-51. doi: 10.1002/mus.20229

  • Lemay, M.A. & Grill, W.M. (2004). Modularity of Motor Output Evoked by Intraspinal Microstimulation in Cats. Journal of Neurophysiology, 91(1), pp. 502-514. doi: 10.1152/jn.00235.2003

  • Maltenfort, M.G., Markin, S., Lemay, M.A., & Giszter, S.F. (2003). Fine Control of Acceleration and Force at the Cat's Toe. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 1734-1737.

  • Bhowmik, M., Boyce, V., McConnell, G., Joyce, D.M., Grill, W.M., & Lemay, M.A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. Bioengineering, Proceedings of the Northeast Conference, pp. 37-38.

  • Bhowmik, M., Boyce, V., McConnell, G., Joyce, D.M., Grill, W.M., & Lemay, M.A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 37-38.

  • Giszter, S.F., Scabich, J.T., Ellis-Davies, G., Simansky, K.J., & Lemay, M.A. (2002). Photolytic uncaging of neurotransmitters as a control and stimulation device for neural tissues. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 3, pp. 2072-2073.

  • Bhowmik, M., Tobias, C.A., Fischer, I., Murray, M., & Lemay, M.A. (2002). Locomotor recovery promoted by sensorimotor training and the graft of fibroblasts genetically engineered to produce BDNF and NT3 in the injured cat spinal cord. Bioengineering, Proceedings of the Northeast Conference, pp. 233-234.

  • Scabich, J.A., Ellis-Davies, G., Lemay, M.A., & Giszter, S.F. (2002). Testing of photolytic uncaging with intraspinal fiber optics as a basis for motor neuroprostheses. Bioengineering, Proceedings of the Northeast Conference, pp. 151-152.

  • Lemay, M.A., McConnell, G.C., Kao, T., Joyce, D.M., & Grill, W.M. (2002). Endpoint forces obtained during intraspinal microstimulation of the cat lumbar spinal cord - Experimental and biomechanical model results. Bioengineering, Proceedings of the Northeast Conference, pp. 113-114. doi: 10.1109/NEBC.2002.999491

  • Bhowmik, M., Tobias, C.A., Fischer, I., Murray, M., & Lemay, M.A. (2002). Locomotor recovery promoted by sensorimotor training and the graft of fibroblasts genetically engineered to produce BDNF and NT3 in the injured cat spinal cord. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 233-234.

  • Scabich, J.A., Ellis-Davies, G., Lemay, M.A., & Giszter, S.F. (2002). Testing of photolytic uncaging with intraspinal fiber optics as a basis for motor neuroprostheses. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 151-152.

  • Lemay, M.A., Galagan, J.E., Hogan, N., & Bizzi, E. (2001). Modulation and vectorial summation of the spinalized frog's hindlimb end-point force produced by intraspinal electrical stimulation of the cord. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 9(1), pp. 12-23. doi: 10.1109/7333.918272

  • Lemay, M.A. & Grill, W.M. (2000). Endpoint force patterns evoked by intraspinal stimulation - Ipsilateral and contralateral responses. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 918-920.

  • Giszter, S.F., Grill, W.M., Lemay, M.A., Mushahwar, V.K., & Prochazka, A. (2000). Intraspinal microstimulation: Techniques, perspectives and prospects for FES. In Neural Prostheses for Restoration of Sensory and Motor Function (pp. 101-138).

  • Lemay, M.A. & Grill, W.M. (1999). Endpoint forces evoked by microstimulation of the cat spinal cord. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, p. 481.

  • Barbeau, H., McCrea, D.A., O'Donovan, M.J., Rossignol, S., Grill, W.M., & Lemay, M.A. (1999). Tapping into spinal circuits to restore motor function. Brain Research Reviews, 30(1), pp. 27-51. doi: 10.1016/S0165-0173(99)00008-9

  • Lemay, M.A., Hogan, N., & Dorsten, J.V. (1998). Issues in impedance selection and input devices for multijoint powered orthotics. IEEE Transactions on Rehabilitation Engineering, 6(1), pp. 102-105. doi: 10.1109/86.662626

  • Lemay, M.A. & Crago, P.E. (1997). Closed-loop wrist stabilization in C4 and C5 tetraplegia. IEEE Transactions on Rehabilitation Engineering, 5(3), pp. 244-252. doi: 10.1109/86.623016

  • Lemay, M.A., Hogan, N., & Bizzi, E. (1996). Recruitment modulation of force fields organized in the frog's spinal cord. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 591-592.

  • Lemay, M.A. & Crago, P.E. (1996). A dynamic model for simulating movements of the elbow, forearm, and wrist. Journal of Biomechanics, 29(10), pp. 1319-1330. doi: 10.1016/0021-9290(96)00026-7

  • Lemay, M.A., Crago, P.E., & Keith, M.W. (1996). Restoration of pronosupination control by FNS in tetraplegia - Experimental and biomechanical evaluation of feasibility. Journal of Biomechanics, 29(4), pp. 435-442. doi: 10.1016/0021-9290(95)00076-3

  • Keith, M.W., Kilgore, K.L., Peckham, P.H., Wuolle, K.S., Creasey, G., & Lemay, M. (1996). Tendon transfers and functional electrical stimulation for restoration of hand function in spinal cord injury. Journal of Hand Surgery, 21(1), pp. 89-99. doi: 10.1016/S0363-5023(96)80160-2

  • Lemay, M.A. & Crago, P.E. (1995). Feasibility of pronosupination control by functional neuromuscular stimulation in tetraplegia: Experimental and biomechanical evaluation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 17(2), pp. 1155-1156.

  • Lemay, M.A., Crago, P.E., Keith, M.W., & Peckham, P.H. (1994). Wrist flexion/extension control in C5 and C4 quadriplegic subjects using functional neuromuscular stimulation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 16(pt 1), pp. 438-439.

  • Lemay, M.A., Crago, P.E., Katorgi, M., & Chapman, G.J. (1993). Automated Tuning of a Closed-Loop Hand Grasp Neuroprosthesis. IEEE Transactions on Biomedical Engineering, 40(7), pp. 675-685. doi: 10.1109/10.237697

  • Crago, P.E. & Lemay, M. (1989). Active regulation of grasp stiffness in neuroprosthesis for restoration of hand function in quadriplegics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 11 pt 3, pp. 902-903.