Biography

Michel A Lemay, PhD is a Professor in the Department of Bioengineering at Temple University. His research group focuses on understanding the functioning and contribution of the spinal circuitry to the control of locomotion, and how this circuitry can be re-engaged for rehabilitation purposes following injury. Dr.Lemay's group uses a number of tools to activate and probe the spinal circuitry, techniques ranging from cellular delivery of neurotrophic factors to electrical stimulation of the spinal cord or its afferent feedback to locomotor re-training and multiunit recording of interneuronal activity during locomotion. Prior to coming to Temple University, Dr. Lemay was a Professor in the Department of Neurobiology and Anatomy at Drexel University College of Medicine, and a Principal Investigator in the Spinal Cord Research Center at this institution. Dr. Lemay received his PhD and MS in Biomedical Engineering from Case Western Reserve University, and trained as a post-doctoral fellow under Drs. Neville Hogan and Emilio Bizzi at the Massachusetts Institute of Technology.

Research Interests

  • Neural Engineering
  • Spinal Cord Role in Movement
  • Spinal Cord Injury & Plasticity
  • Spinal Circuitry
  • Biomechanics
  • Neuroprosthesis

Courses Taught

Number

Name

Level

BIOE 3201

Biomedical Instrumentation

Undergraduate

Selected Publications

  • McMahon, C., Kowalski, D.P., Krupka, A.J., & Lemay, M.A. (2022). Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat. J Neurophysiol, 127(1), pp. 99-115. United States. doi: 10.1152/jn.00202.2021

  • Vahedipour, A., Short, M.R., Timnak, A., Maghsoudi, O.H., Hallowell, T., Gerstenhaber, J., Cappellari, O., Lemay, M., & Spence, A.J. (2021). A versatile system for neuromuscular stimulation and recording in the mouse model using a lightweight magnetically coupled headmount. J Neurosci Methods, 362, p. 109319. Netherlands. doi: 10.1016/j.jneumeth.2021.109319

  • Moukarzel, G., Lemay, M.A., & Spence, A.J. (2021). A MATLAB application for automated H-Reflex measurements and analyses. Biomed Signal Process Control, 66. England. doi: 10.1016/j.bspc.2021.102448

  • Marchionne, F., Krupka, A.J., Smith, G.M., & Lemay, M.A. (2020). Intrathecal Delivery of BDNF Into the Lumbar Cistern Re-Engages Locomotor Stepping After Spinal Cord Injury. IEEE Trans Neural Syst Rehabil Eng, 28(11), pp. 2459-2467. United States. doi: 10.1109/TNSRE.2020.3027393

  • Higgin, D., Krupka, A., Maghsoudi, O.H., Klishko, A.N., Nichols, T.R., Lyle, M.A., Prilutsky, B.I., & Lemay, M.A. (2020). Adaptation to slope in locomotor-trained spinal cats with intact and self-reinnervated lateral gastrocnemius and soleus muscles. J Neurophysiol, 123(1), pp. 70-89. United States. doi: 10.1152/jn.00018.2019

  • Eisdorfer, J.T., Smit, R.D., Keefe, K.M., Lemay, M.A., Smith, G.M., & Spence, A.J. (2020). Epidural Electrical Stimulation: A Review of Plasticity Mechanisms That Are Hypothesized to Underlie Enhanced Recovery From Spinal Cord Injury With Stimulation. Front Mol Neurosci, 13, p. 163. Switzerland. doi: 10.3389/fnmol.2020.00163

  • Tiwari, E., Barbe, M.F., Lemay, M.A., Salvadeo, D.M., Wood, M.W., Mazzei, M., Musser, L.V., Delalic, Z.J., Braverman, A.S., & Ruggieri, M.R. (2019). Acute bladder decentralization in hound dogs: Preliminary results of effects on hypogastric nerve electroneurograms and detrusor pressure responses to spinal root and hypogastric nerve stimulation. PLoS One, 14(4), p. e0215036. United States. doi: 10.1371/journal.pone.0215036

  • Tom, B., Witko, J., Lemay, M., & Singh, A. (2018). Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury. Exp Brain Res, 236(11), pp. 3077-3084. Germany. doi: 10.1007/s00221-018-5344-x

  • Salako, K., Lakshmanan, S., McMahon, C., & Lemay, M. (2018). Analysis of the mammalian central pattern generator through the characterization of lumbar interneuronal activity. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257037

  • Marchionne, F., Krupka, A.J., & Lemay, M.A. (2017). Effects of chronic intrathecal infusion of BDNF on interneuronal activity in a large animal model of spinal cord injury. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257035

  • Côté, M., Murray, M., & Lemay, M.A. (2017). Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure. J Neurotrauma, 34(10), pp. 1841-1857. United States. doi: 10.1089/neu.2016.4577

  • Krupka, A.J., Fischer, I., & Lemay, M.A. (2017). Transplants of Neurotrophin-Producing Autologous Fibroblasts Promote Recovery of Treadmill Stepping in the Acute, Sub-Chronic, and Chronic Spinal Cat. J Neurotrauma, 34(10), pp. 1858-1872. United States. doi: 10.1089/neu.2016.4559

  • Dimiskovski, M., Scheinfield, R., Higgin, D., Krupka, A., & Lemay, M.A. (2017). Characterization and validation of a split belt treadmill for measuring hindlimb ground-reaction forces in able-bodied and spinalized felines. J Neurosci Methods, 278, pp. 65-75. Netherlands. doi: 10.1016/j.jneumeth.2017.01.002

  • Grove, M., Kim, H., Santerre, M., Krupka, A.J., Han, S.B., Zhai, J., Cho, J.Y., Park, R., Harris, M., Kim, S., Sawaya, B.E., Kang, S.H., Barbe, M.F., Cho, S., Lemay, M.A., & Son, Y. (2017). YAP/TAZ initiate and maintain Schwann cell myelination. Elife, 6. England. doi: 10.7554/eLife.20982

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2015). A Neuromechanical Model of Spinal Control of Locomotion. In Neuromechanical Modeling of Posture and Locomotion (pp. 21-65). doi: 10.1007/978-1-4939-3267-2_2

  • Lemay, M. & Giszter, S.F. (2015). Intraspinal Stimulation. In Encyclopedia of Computational Neuroscience (pp. 1448-1453). doi: 10.1007/978-1-4614-6675-8_594

  • Lemay, M. (2015). Spinal Interfaces: Overview. In Encyclopedia of Computational Neuroscience (pp. 104-108). doi: 10.1007/978-1-4614-6675-8_785

  • Ollivier-Lanvin, K., Fischer, I., Tom, V., Houlé, J.D., & Lemay, M.A. (2015). Either brain-derived neurotrophic factor or neurotrophin-3 only neurotrophin-producing grafts promote locomotor recovery in untrained spinalized cats. Neurorehabil Neural Repair, 29(1), pp. 90-100. United States. doi: 10.1177/1545968314532834

  • Xu, C., Klaw, M.C., Lemay, M.A., Baas, P.W., & Tom, V.J. (2015). Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury. Exp Neurol, 263, pp. 172-176. United States. doi: 10.1016/j.expneurol.2014.10.013

  • Bonner, J.F., Connors, T.M., Silverman, W.F., Kowalski, D.P., Lemay, M.A., & Fischer, I. (2013). Grafted Neural Progenitors Integrate and Restore Synaptic Activity across the Injured Spinal Cord (vol 31, pg 4675, 2011). JOURNAL of NEUROSCIENCE, 33(15), pp. 6705-6705. doi: 10.1523/JNEUROSCI.1003-13.2013

  • Tom, V.J., Sandrow-Feinberg, H.R., Miller, K., Domitrovich, C., Bouyer, J., Zhukareva, V., Klaw, M.C., Lemay, M.A., & Houlé, J.D. (2013). Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site. Exp Neurol, 239, pp. 91-100. United States. doi: 10.1016/j.expneurol.2012.09.011

  • Markin, S.N., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2012). Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study. J Neurophysiol, 107(8), pp. 2057-2071. United States. doi: 10.1152/jn.00865.2011

  • Côté, M., Detloff, M.R., Wade, R.E., Lemay, M.A., & Houlé, J.D. (2012). Plasticity in ascending long propriospinal and descending supraspinal pathways in chronic cervical spinal cord injured rats. Front Physiol, 3, p. 330. Switzerland. doi: 10.3389/fphys.2012.00330

  • Singh, A., Balasubramanian, S., Murray, M., Lemay, M., & Houle, J. (2011). Role of spared pathways in locomotor recovery after body-weight-supported treadmill training in contused rats. J Neurotrauma, 28(12), pp. 2405-2416. United States. doi: 10.1089/neu.2010.1660

  • Auyong, N., Ollivier-Lanvin, K., & Lemay, M.A. (2011). Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats. J Neurophysiol, 106(4), pp. 1943-1953. United States. doi: 10.1152/jn.00258.2011

  • Ollivier-Lanvin, K., Krupka, A.J., AuYong, N., Miller, K., Prilutsky, B.I., & Lemay, M.A. (2011). Electrical stimulation of the sural cutaneous afferent nerve controls the amplitude and onset of the swing phase of locomotion in the spinal cat. J Neurophysiol, 105(5), pp. 2297-2308. United States. doi: 10.1152/jn.00385.2010

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., McCrea, D.A., & Rybak, I.A. (2011). Modeling the CPG-based Control of Cat Hindlimb Movement During Locomotion. FASEB JOURNAL, 25. Retrieved from http://gateway.webofknowledge.com/

  • Bonner, J.F., Connors, T.M., Silverman, W.F., Kowalski, D.P., Lemay, M.A., & Fischer, I. (2011). Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord. J Neurosci, 31(12), pp. 4675-4686. United States. doi: 10.1523/JNEUROSCI.4130-10.2011

  • AuYong, N., Ollivier-Lanvin, K., & Lemay, M.A. (2011). Preferred locomotor phase of activity of lumbar interneurons during air-stepping in subchronic spinal cats. J Neurophysiol, 105(3), pp. 1011-1022. United States. doi: 10.1152/jn.00523.2010

  • Côté, M., Azzam, G.A., Lemay, M.A., Zhukareva, V., & Houlé, J.D. (2011). Activity-dependent increase in neurotrophic factors is associated with an enhanced modulation of spinal reflexes after spinal cord injury. J Neurotrauma, 28(2), pp. 299-309. United States. doi: 10.1089/neu.2010.1594

  • Côté, M., Hanna, A., Lemay, M.A., Ollivier-Lanvin, K., Santi, L., Miller, K., Monaghan, R., & Houlé, J.D. (2010). Peripheral nerve grafts after cervical spinal cord injury in adult cats. Exp Neurol, 225(1), pp. 173-182. United States. doi: 10.1016/j.expneurol.2010.06.011

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2010). Afferent control of locomotor CPG: insights from a simple neuromechanical model. Ann N Y Acad Sci, 1198, pp. 21-34. United States. doi: 10.1111/j.1749-6632.2010.05435.x

  • Ollivier-Lanvin, K., Keeler, B.E., Siegfried, R., Houlé, J.D., & Lemay, M.A. (2010). Proprioceptive neuropathy affects normalization of the H-reflex by exercise after spinal cord injury. Exp Neurol, 221(1), pp. 198-205. United States. doi: 10.1016/j.expneurol.2009.10.023

  • Tom, V.J., Sandrow-Feinberg, H.R., Miller, K., Santi, L., Connors, T., Lemay, M.A., & Houlé, J.D. (2009). Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord. J Neurosci, 29(47), pp. 14881-14890. United States. doi: 10.1523/JNEUROSCI.3641-09.2009

  • Houle, J.D., Amin, A., Cote, M., Lemay, M., Miller, K., Sandrow, H., Santi, L., Shumsky, J., & Tom, V. (2009). Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. J Vis Exp.(33). United States. doi: 10.3791/1324

  • Ollivier-Lanvin, K., Lemay, M.A., Tessler, A., & Burns, A.S. (2009). Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury. J Appl Physiol (1985), 107(4), pp. 1190-1194. United States. doi: 10.1152/japplphysiol.00282.2009

  • Lemay, M.A., Grasse, D., & Grill, W.M. (2009). Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats. IEEE Trans Neural Syst Rehabil Eng, 17(4), pp. 379-389. United States. doi: 10.1109/TNSRE.2009.2023295

  • Boyce, V.S. & Lemay, M.A. (2009). Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin-treated chronic spinal cats. J Neurophysiol, 101(3), pp. 1309-1320. United States. doi: 10.1152/jn.00034.2008

  • Boyce, V.S., Tumolo, M., Fischer, I., Murray, M., & Lemay, M.A. (2007). Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. J Neurophysiol, 98(4), pp. 1988-1996. United States. doi: 10.1152/jn.00391.2007

  • Burns, A.S., Boyce, V.S., Tessler, A., & Lemay, M.A. (2007). Fibrillation potentials following spinal cord injury: improvement with neurotrophins and exercise. Muscle Nerve, 35(5), pp. 607-613. United States. doi: 10.1002/mus.20738

  • Lemay, M.A., Bhowmik-Stoker, M., McConnell, G.C., & Grill, W.M. (2007). Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb. J Biomech, 40(16), pp. 3679-3687. United States. doi: 10.1016/j.jbiomech.2007.06.021

  • Boyce, V.S. & Lemay, M.A. (2005). Proportions of endpoint force pattern types obtained via intraspinal micro stimulation in chronically spinalized cats are dependent on sensorimotor training. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, pp. 473-474. doi: 10.1109/CNE.2005.1419662

  • Silverman, J., Garnett, N.L., Giszter, S.F., Heckman, C.J., Kulpa-Eddy, J.A., Lemay, M.A., Perry, C.K., & Pinter, M. (2005). Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion. Contemp Top Lab Anim Sci, 44(4), pp. 34-36. United States. Retrieved from https://www.ncbi.nlm.nih.gov/

  • Lemay, M.A., Boyce, V.S., Tumolo, M.A., Murray, M., Fischer, I., & Burns, A.S. (2005). Neurotrophic factors promote locomotor recovery and changes in muscle electromyography in chronically spinalized animals. FASEB JOURNAL, 19(5), pp. A1649-A1649. Retrieved from http://gateway.webofknowledge.com/

  • Burns, A.S., Lemay, M.A., & Tessler, A. (2005). Abnormal spontaneous potentials in distal muscles in animal models of spinal cord injury. Muscle Nerve, 31(1), pp. 46-51. United States. doi: 10.1002/mus.20229

  • Lemay, M.A. & Grill, W.M. (2004). Modularity of motor output evoked by intraspinal microstimulation in cats. J Neurophysiol, 91(1), pp. 502-514. United States. doi: 10.1152/jn.00235.2003

  • Maltenfort, M.G., Markin, S., Lemay, M.A., & Giszter, S.F. (2003). Fine Control of Acceleration and Force at the Cat's Toe. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 1734-1737.

  • Bhowmik, M., Boyce, V., McConnell, G., Joyce, D.M., Grill, W.M., & Lemay, M.A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. Bioengineering, Proceedings of the Northeast Conference, pp. 37-38.

  • Bhowmik, M., Boyce, V., McConnell, G., Joyce, D.M., Grill, W.M., & Lemay, M.A. (2003). Experimental and biomechanical model force fields produced by intraspinal microstimulation of the cat lumbar spinal cord. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 37-38.

  • Giszter, S.F., Scabich, J.T., Ellis-Davies, G., Simansky, K.J., & Lemay, M.A. (2002). Photolytic uncaging of neurotransmitters as a control and stimulation device for neural tissues. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 3, pp. 2072-2073.

  • Bhowmik, M., Tobias, C.A., Fischer, I., Murray, M., & Lemay, M.A. (2002). Locomotor recovery promoted by sensorimotor training and the graft of fibroblasts genetically engineered to produce BDNF and NT3 in the injured cat spinal cord. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 233-234.

  • Scabich, J.A., Ellis-Davies, G., Lemay, M.A., & Giszter, S.F. (2002). Testing of photolytic uncaging with intraspinal fiber optics as a basis for motor neuroprostheses. Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, pp. 151-152.

  • Bhowmik, M., Tobias, C.A., Fischer, I., Murray, M., & Lemay, M.A. (2002). Locomotor recovery promoted by sensorimotor training and the graft of fibroblasts genetically engineered to produce BDNF and NT3 in the injured cat spinal cord. Bioengineering, Proceedings of the Northeast Conference, pp. 233-234.

  • Scabich, J.A., Ellis-Davies, G., Lemay, M.A., & Giszter, S.F. (2002). Testing of photolytic uncaging with intraspinal fiber optics as a basis for motor neuroprostheses. Bioengineering, Proceedings of the Northeast Conference, pp. 151-152.

  • Lemay, M.A., McConnell, G.C., Kao, T., Joyce, D.M., & Grill, W.M. (2002). Endpoint forces obtained during intraspinal microstimulation of the cat lumbar spinal cord - Experimental and biomechanical model results. Bioengineering, Proceedings of the Northeast Conference, pp. 113-114. doi: 10.1109/NEBC.2002.999491

  • Lemay, M.A., Galagan, J.E., Hogan, N., & Bizzi, E. (2001). Modulation and vectorial summation of the spinalized frog's hindlimb end-point force produced by intraspinal electrical stimulation of the cord. IEEE Trans Neural Syst Rehabil Eng, 9(1), pp. 12-23. United States. doi: 10.1109/7333.918272

  • Lemay, M.A. & Grill, W.M. (2000). Endpoint force patterns evoked by intraspinal stimulation - Ipsilateral and contralateral responses. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 918-920.

  • Giszter, S.F., Grill, W.M., Lemay, M.A., Mushahwar, V.K., & Prochazka, A. (2000). Intraspinal microstimulation: Techniques, perspectives and prospects for FES. In Neural Prostheses for Restoration of Sensory and Motor Function (pp. 101-138).

  • Lemay, M.A. & Grill, W.M. (1999). Endpoint forces evoked by microstimulation of the cat spinal cord. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, p. 481.

  • Barbeau, H., McCrea, D.A., O'Donovan, M.J., Rossignol, S., Grill, W.M., & Lemay, M.A. (1999). Tapping into spinal circuits to restore motor function. Brain Res Brain Res Rev, 30(1), pp. 27-51. Netherlands. doi: 10.1016/s0165-0173(99)00008-9

  • Lemay, M.A., Hogan, N., & Dorsten, J.W.v. (1998). Issues in impedance selection and input devices for multijoint powered orthotics. IEEE Trans Rehabil Eng, 6(1), pp. 102-105. United States. doi: 10.1109/86.662626

  • Lemay, M.A. & Crago, P.E. (1997). Closed-loop wrist stabilization in C4 and C5 tetraplegia. IEEE Trans Rehabil Eng, 5(3), pp. 244-252. United States. doi: 10.1109/86.623016

  • Lemay, M.A., Hogan, N., & Bizzi, E. (1996). Recruitment modulation of force fields organized in the frog's spinal cord. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, pp. 591-592.

  • Lemay, M.A. & Crago, P.E. (1996). A dynamic model for simulating movements of the elbow, forearm, an wrist. J Biomech, 29(10), pp. 1319-1330. United States. doi: 10.1016/0021-9290(96)00026-7

  • Lemay, M.A., Crago, P.E., & Keith, M.W. (1996). Restoration of pronosupination control by FNS in tetraplegia--experimental and biomechanical evaluation of feasibility. J Biomech, 29(4), pp. 435-442. United States. doi: 10.1016/0021-9290(95)00076-3

  • Keith, M.W., Kilgore, K.L., Peckham, P.H., Wuolle, K.S., Creasey, G., & Lemay, M. (1996). Tendon transfers and functional electrical stimulation for restoration of hand function in spinal cord injury. J Hand Surg Am, 21(1), pp. 89-99. United States. doi: 10.1016/s0363-5023(96)80160-2

  • Lemay, M.A. & Crago, P.E. (1995). Feasibility of pronosupination control by functional neuromuscular stimulation in tetraplegia: Experimental and biomechanical evaluation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 17(2), pp. 1155-1156.

  • Lemay, M.A., Crago, P.E., Keith, M.W., & Peckham, P.H. (1994). Wrist flexion/extension control in C5 and C4 quadriplegic subjects using functional neuromuscular stimulation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 16(pt 1), pp. 438-439.

  • Lemay, M.A., Crago, P.E., Katorgi, M., & Chapman, G.J. (1993). Automated tuning of a closed-loop hand grasp neuroprosthesis. IEEE Trans Biomed Eng, 40(7), pp. 675-685. United States. doi: 10.1109/10.237697

  • Crago, P.E. & Lemay, M. (1989). Active regulation of grasp stiffness in neuroprosthesis for restoration of hand function in quadriplegics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 11 pt 3, pp. 902-903.