Biography

Michel A Lemay, PhD is a Professor in the Department of Bioengineering at Temple University. His research group focuses on understanding the functioning and contribution of the spinal circuitry to the control of locomotion, and how this circuitry can be re-engaged for rehabilitation purposes following injury. Dr.Lemay's group uses a number of tools to activate and probe the spinal circuitry, techniques ranging from cellular delivery of neurotrophic factors to electrical stimulation of the spinal cord or its afferent feedback to locomotor re-training and multiunit recording of interneuronal activity during locomotion. Prior to coming to Temple University, Dr. Lemay was a Professor in the Department of Neurobiology and Anatomy at Drexel University College of Medicine, and a Principal Investigator in the Spinal Cord Research Center at this institution. Dr. Lemay received his PhD and MS in Biomedical Engineering from Case Western Reserve University, and trained as a post-doctoral fellow under Drs. Neville Hogan and Emilio Bizzi at the Massachusetts Institute of Technology.

Research Interests

  • Neural Engineering
  • Spinal Cord Role in Movement
  • Spinal Cord Injury & Plasticity
  • Spinal Circuitry
  • Biomechanics
  • Neuroprosthesis

Courses Taught

Number

Name

Level

BIOE 3101

BioE Lab #1 - Bioelectrical Engineering

Undergraduate

BIOE 3201

Biomedical Instrumentation

Undergraduate

Selected Publications

  • Tiwari, E., Barbe, M.F., Lemay, M.A., Salvadeo, D.M., Wood, M.W., Mazzei, M., Musser, L.V., Delalic, Z.J., Braverman, A.S., & Ruggieri, M.R. (2019). Acute bladder decentralization in hound dogs: Preliminary results of effects on hypogastric nerve electroneurograms and detrusor pressure responses to spinal root and hypogastric nerve stimulation. PLoS ONE, 14(4). doi: 10.1371/journal.pone.0215036

  • Tom, B., Witko, J., Lemay, M., & Singh, A. (2018). Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury. Experimental Brain Research, 236(11), pp. 3077-3084. doi: 10.1007/s00221-018-5344-x

  • Salako, K., Lakshmanan, S., McMahon, C., & Lemay, M. (2018). Analysis of the mammalian central pattern generator through the characterization of lumbar interneuronal activity. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257037

  • Marchionne, F., Krupka, A.J., & Lemay, M.A. (2018). Effects of chronic intrathecal infusion of BDNF on interneuronal activity in a large animal model of spinal cord injury. 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings, 2018-January, pp. 1-3. doi: 10.1109/SPMB.2017.8257035

  • Côté, M.P., Murray, M., & Lemay, M.A. (2017). Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure. Journal of Neurotrauma, 34(10), pp. 1841-1857. doi: 10.1089/neu.2016.4577

  • Krupka, A.J., Fischer, I., & Lemay, M.A. (2017). Transplants of Neurotrophin-Producing Autologous Fibroblasts Promote Recovery of Treadmill Stepping in the Acute, Sub-Chronic, and Chronic Spinal Cat. Journal of Neurotrauma, 34(10), pp. 1858-1872. doi: 10.1089/neu.2016.4559

  • Dimiskovski, M., Scheinfield, R., Higgin, D., Krupka, A., & Lemay, M.A. (2017). Characterization and validation of a split belt treadmill for measuring hindlimb ground-reaction forces in able-bodied and spinalized felines. Journal of Neuroscience Methods, 278, pp. 65-75. doi: 10.1016/j.jneumeth.2017.01.002

  • Grove, M., Kim, H., Santerre, M., Krupka, A.J., Han, S.B., Zhai, J., Cho, J.Y., Park, R., Harris, M., Kim, S., Sawaya, B.E., Kang, S.H., Barbe, M.F., Cho, S.H., Lemay, M.A., & Son, Y.J. (2017). YAP/TAZ initiate and maintain schwann cell myelination. ELife, 6. doi: 10.7554/eLife.20982

  • Markin, S.N., Klishko, A.N., Shevtsova, N.A., Lemay, M.A., Prilutsky, B.I., & Rybak, I.A. (2016). A Neuromechanical Model of Spinal Control of Locomotion. In Neuromechanical Modeling of Posture and Locomotion (pp. 21-65). Springer New York. doi: 10.1007/978-1-4939-3267-2_2

  • Lemay, M. (2015). Spinal Interfaces: Overview. In Encyclopedia of Computational Neuroscience (pp. 104-108). Springer New York. doi: 10.1007/978-1-4614-6675-8_785

  • Lemay, M. & Giszter, S.F. (2015). Intraspinal Stimulation. In Encyclopedia of Computational Neuroscience (pp. 1448-1453). Springer New York. doi: 10.1007/978-1-4614-6675-8_594

  • Xu, C., Klaw, M.C., Lemay, M.A., Baas, P.W., & Tom, V.J. (2015). Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury. Experimental Neurology, 263, pp. 172-176. doi: 10.1016/j.expneurol.2014.10.013

  • Ollivier-Lanvin, K., Fischer, I., Tom, V., Houlé, J.D., & Lemay, M.A. (2015). Either brain-derived neurotrophic factor or neurotrophin-3 only neurotrophin-producing grafts promote locomotor recovery in untrained spinalized cats. Neurorehabilitation and Neural Repair, 29(1), pp. 90-100. doi: 10.1177/1545968314532834