Biography

Dr. Patil earned a Ph.D. in Biomedical Engineering from Vanderbilt University in Nashville, TN, where he also served as a post doctoral research fellow in the Center for Biomedical Optics. Prior to joining Temple University, Dr. Patil was a Research Assistant Professor in the Department of Biomedical Engineering at Vanderbilt University. His research is focused on the development of label-free, biochemically specific, optical imaging and spectroscopy techniques for screening and diagnosis of disease, intra-operative surgical guidance, and applications to priority issues in global health. Dr. Patil’s work has been included in journals such as Optics Letters, Journal of Biomedical Optics, and Optics Express.

Research Interests

  • Optical Imaging & Spectroscopy
  • Disease Screening & Diagnosis
  • Intra-Operative Surgical Guidance
  • Optical Technologies in Global Health

Courses Taught

Number

Name

Level

BIOE 3201

Biomedical Instrumentation

Undergraduate

BIOE 3301

Biomedical Signals and Systems

Undergraduate

BIOE 4333

Capstone Elective: Applied Biospectroscopy

Undergraduate

BIOE 4333

Applied Biospectroscopy

Undergraduate

BIOE 4500

Special Topics: Biosignals

Undergraduate

BIOE 5301

Biosignals

Graduate

BIOE 5333

Applied Biospectroscopy

Graduate

Selected Publications

  • Dumont, A.P., Fang, Q., & Patil, C.A. (2021). A computationally efficient Monte-Carlo model for biomedical Raman spectroscopy. Journal of Biophotonics, 14(7). doi: 10.1002/jbio.202000377

  • Shanas, N., Querido, W., Dumont, A., Yonko, E., Carter, E., Ok, J., Karchner, J.P., Barbe, M.F., Ali, S., Patil, C., Raggio, C., & Pleshko, N. (2020). Clinical application of near infrared fiber optic spectroscopy for noninvasive bone assessment. Journal of Biophotonics, 13(4). doi: 10.1002/jbio.201960172

  • Haifler, M., Pence, I., Sun, Y., Kutikov, A., Uzzo, R.G., Mahadevan-Jansen, A., & Patil, C.A. (2018). Discrimination of malignant and normal kidney tissue with short wave infrared dispersive Raman spectroscopy. Journal of Biophotonics, 11(6). doi: 10.1002/jbio.201700188

  • Dumont, A.P. & Patil, C. (2018). Development of accelerated Raman and fluorescent Monte Carlo method. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10490. doi: 10.1117/12.2293831

  • Dumont, A.P., Harrison, B., Mccormick, Z.T., Kumar, N.G., & Patil, C.A. (2017). Development of mobile phone based transcutaneous billirubinometry. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10055. doi: 10.1117/12.2257428

  • Pence, I.J., Patil, C.A., Lieber, C.A., & Mahadevan-Jansen, A. (2015). Discrimination of liver malignancies with 1064 nm dispersive Raman spectroscopy. Biomedical Optics Express, 6(8), pp. 2724-2737. doi: 10.1364/BOE.6.002724

  • Tucker-Schwartz, J.M., Lapierre-Landry, M., Patil, C.A., & Skala, M.C. (2015). Photothermal optical lock-in optical coherence tomography for in vivo imaging. Biomedical Optics Express, 6(6), pp. 2268-2282. doi: 10.1364/BOE.6.002268

  • Mahadevan-Jansen, A., Patil, C.A., & Pence, I.J. (2014). Raman spectroscopy: From benchtop to bedside. In Biomedical Photonics Handbook (pp. 759-802).

  • Patil, C.A., Pence, I.J., Lieber, C.A., & Mahadevan-Jansen, A. (2014). 1064 nm dispersive Raman spectroscopy of tissues with strong near-infrared autofluorescence. Optics Letters, 39(2), pp. 303-306. doi: 10.1364/OL.39.000303

  • Mahadevan-Jansen, A., Patil, C.A., & Pence, I.J. (2014). Raman spectroscopy: From benchtop to bedside. In Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics (pp. 759-802). doi: 10.1201/b17289

  • Poole, K.M., McCormack, D.R., Patil, C.A., Duvall, C.L., & Skala, M.C. (2014). Quantifying the vascular response to ischemia with speckle variance optical coherence tomography. Biomedical Optics Express, 5(12), pp. 4118-4130. doi: 10.1364/BOE.5.004118

  • Trantum, J.R., Eagleton, Z.E., Patil, C.A., Tucker-Schwartz, J.M., Baglia, M.L., Skala, M.C., & Haselton, F.R. (2013). Cross-sectional tracking of particle motion in evaporating drops: Flow fields and interfacial accumulation. Langmuir, 29(21), pp. 6221-6231. doi: 10.1021/la400542x

  • Tucker-Schwartz, J.M., Meyer, T.A., Patil, C.A., Duvall, C.L., & Skala, M.C. (2013). In vivo imaging of gold nanorod contrast agents using photothermal optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8571. doi: 10.1117/12.2007202

  • Makowski, A.J., Patil, C.A., Mahadevan-Jansen, A., & Nyman, J.S. (2013). Polarization control of Raman spectroscopy optimizes the assessment of bone tissue. Journal of Biomedical Optics, 18(5). doi: 10.1117/1.JBO.18.5.055005

  • Poole, K.M., Patil, C.A., Nelson, C.E., McCormack, D.R., Madonna, M.C., Duvall, C.L., & Skala, M.C. (2013). Longitudinal study of arteriogenesis with swept source optical coherence tomography and hyperspectral imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8934. doi: 10.1117/12.2042037

  • Tucker-Schwartz, J.M., Meyer, T.A., Patil, C.A., Duvall, C.L., & Skala, M.C. (2012). In vivo photothermal optical coherence tomography of gold nanorod contrast agents. Biomedical Optics Express, 3(11), pp. 2881-2895. doi: 10.1364/BOE.3.002881

  • Patil, C.A., Arrasmith, C.L., Mackanos, M.A., Dickensheets, D.L., & Mahadevan-Jansen, A. (2012). A handheld laser scanning confocal reflectance imaging-confocal Raman microspectroscopy system. Biomedical Optics Express, 3(3), pp. 488-502. doi: 10.1364/BOE.3.000488

  • Nyman, J.S., Makowski, A.J., Patil, C.A., Masui, T.P., O'Quinn, E.C., Bi, X., Guelcher, S.A., Nicollela, D.P., & Mahadevan-Jansen, A. (2011). Measuring differences in compositional properties of bone tissue by confocal raman spectroscopy. Calcified Tissue International, 89(2), pp. 111-122. doi: 10.1007/s00223-011-9497-x

  • Nyman, J.S., Lynch, C.C., Perrien, D.S., Thiolloy, S., O'Quinn, E.C., Patil, C.A., Bi, X., Pharr, G.M., Mahadevan-Jansen, A., & Mundy, G.R. (2011). Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. Journal of Bone and Mineral Research, 26(6), pp. 1252-1260. doi: 10.1002/jbmr.326

  • Patil, C.A., Kirshnamoorthi, H., Ellis, D.L., Leeuwen, T.G.V., & Mahadevan-Jansen, A. (2011). A clinical instrument for combined Raman spectroscopy-optical coherence tomography of skin cancers. Lasers in Surgery and Medicine, 43(2), pp. 143-151. doi: 10.1002/lsm.21041

  • Bi, X., Patil, C.A., Lynch, C.C., Pharr, G.M., Mahadevan-Jansen, A., & Nyman, J.S. (2011). Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. Journal of Biomechanics, 44(2), pp. 297-303. doi: 10.1016/j.jbiomech.2010.10.009

  • Patil, C.A., Kalkman, J., Faber, D.J., Nyman, J.S., Leeuwen, T.G.V., & Mahadevan-Jansen, A. (2011). Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography. Journal of Biomedical Optics, 16(1). doi: 10.1117/1.3520132

  • Bi, X., Patil, C., Morrissey, C., Roudier, M.P., Mahadevan-Jansen, A., & Nyman, J. (2010). Characterization of bone quality in prostate cancer bone metastases using Raman spectroscopy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7548. doi: 10.1117/12.853551

  • Patil, C.A., Kalkman, J., Faber, D., Penn, J.S., Leeuwen, T.G.V., & Jansen, A.M. (2010). Structural and biochemical characterization of the rat retina with combined Raman spectroscopy- Spectral domain Optical Coherence Tomography (RS-SDOCT). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7550. doi: 10.1117/12.843106

  • Patil, C.A., Krishnamoorthi, H., Ellis, D.L., Leeuwen, T.G.V., & Mahadevan-Jansen, A. (2010). A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7548. doi: 10.1117/12.843708

  • Edwards, J.R., Nyman, J.S., Lwin, S.T., Moore, M.M., Esparza, J., O'Quinn, E.C., Hart, A.J., Biswas, S., Patil, C.A., Lonning, S., Mahadevan-Jansen, A., & Mundy, G.R. (2010). Inhibition of TGF-ß signaling by 1D11 antibody treatment increases bone mass and quality in vivo. Journal of Bone and Mineral Research, 25(11), pp. 2419-2426. doi: 10.1002/jbmr.139

  • Patil, C., Krishnamoorthi, H., Mackanos, M., Leeuwen, T.v., Ellis, D., & Mahadevan-Jansen, A. (2010). COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY FOR THE DETECTION OF SKIN CANCERS. LASERS in SURGERY and MEDICINE, pp. 16-17. Retrieved from http://gateway.webofknowledge.com/

  • Nyman, J.S., Lynch, C.C., Thiolloy, S., Patil, C.A., O'Quinn, E.C., Mahadevan-Jansen, A., & Mundy, G.R. (2009). Deletion of the gelatinase MMP-2 affects the compositional and biomechanical properties of bone. 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009. doi: 10.1109/BSEC.2009.5090487

  • Bi, X., Nyman, J.S., Patil, C.A., Masui, P., Lynch, C., & Mahadevan-Jansen, A. (2009). Raman spectroscopy for assessment of bone quality in MMP-2 knockout mice. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7166. doi: 10.1117/12.813928

  • Arrasmith, C.L., Patil, C.A., Dickensheets, D.L., & Mahadevan-Jansen, A. (2009). A MEMS based handheld confocal microscope with Raman spectroscopy for in-vivo skin cancer diagnosis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7169. doi: 10.1117/12.812071

  • Nyman, J.S., Thiolloy, S., Lynch, C.C., Patil, C.A., Yoshii, T., O'Quinn, E., Mahadevan-Jansen, A., & Mundy, G.R. (2008). Regulation of Parameters of Bone Quality by MMP-2 and MMP-9. JOURNAL of BONE and MINERAL RESEARCH, 23, pp. S41-S41. Retrieved from http://gateway.webofknowledge.com/

  • Patil, C.A., Bosschaart, N., Keller, M.D., Leeuwen, T.G.V., & Mahadevan-Jansen, A. (2008). Combined Raman spectroscopy and optical coherence tomography device for tissue characterization. Optics Letters, 33(10), pp. 1135-1137. doi: 10.1364/OL.33.001135

  • Patil, C.A., Bosschaart, N., Nyman, J.S., Faber, D.J., Leeuwen, T.G.V., & Mahadevan-Jansen, A. (2008). Development of combined raman spectroscopy-optical coherence tomography (RS-OCT). Biomedical Optics, BIOMED 2008. doi: 10.1364/biomed.2008.bwd6

  • Patil, C.A. & Jansen, E.D. (2006). Doppler-optical coherence tomography (D-OCT) velocimetry of blood flow in murine tumor microvasculature. Optics InfoBase Conference Papers.

  • Patil, C.A. & Jansen, E.D. (2006). Doppler-optical coherence tomography (D-OCT) velocimetry of blood flow in murine tumor microvasculature. Optics InfoBase Conference Papers. doi: 10.1364/bio.2006.sh3

  • Chalita, M.R., Li, Y., Smith, S., Patil, C., Westphal, V., Rollins, A.M., Izatt, J.A., & Huang, D. (2005). High-speed optical coherence tomography of laser iridotomy. American Journal of Ophthalmology, 140(6), pp. 1133-1136. doi: 10.1016/j.ajo.2005.06.054

  • Goldsmith, J.A., Li, Y., Chalita, M.R., Westphal, V., Patil, C.A., Rollins, A.M., Izatt, J.A., & Huang, D. (2005). Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology, 112(2), pp. 238-244. doi: 10.1016/j.ophtha.2004.09.019

  • Patil, C.A. & Jansen, E.D. (2005). Novel optical technologies to aid diagnosis and guide therapy in colorectal medicine. Seminars in Colon and Rectal Surgery, 16(2), pp. 82-90. doi: 10.1053/j.scrs.2005.08.004

  • Radhakrishnan, S., Patil, C.A., Rollins, A.M., Reeves, D., Lass, J.H., Bardenstein, D.S., Westphal, V., Roth, J.E., & Izatt, J.A. (2002). Real time optical coherence tomography of the anterior segment using hand-held and slit-lamp adapted systems. Proceedings of SPIE-The International Society for Optical Engineering, 4619, pp. 227-229. doi: 10.1117/12.470488