Graduate Research

Graduate Student Research Spotlight

Graduate Research

Research is critical in graduate-level education. It is through research activities that graduate students can apply what they have learned in their undergraduate- and graduate-level coursework to solve real-world problems. Graduate students have opportunities to participate in research activities using the college's cutting-edge research facilities. Additionally, graduate students may conduct interdisciplinary research with departments within other colleges and schools at Temple University, such as the College of Science and Technology and the School of Medicine. Read below to learn more about some of the graduate student research activities.

Embedded design

 

Now in his second year in the Ph.D. program in the Department of Electrical and Computer Engineering, Andrew Powell is well into his research related to embedded design. For many applications, embedded system designers need to construct systems that demand real-time constraints and thus require information on a component’s performance under certain parameters. An important, limiting factor in any computer system’s performance is how quickly components are able to communicate with each other over the system’s bus. Highly integrated systems composed of multiple processing cores, referred to as System-on-Chip device, contains a bus known as an interconnect. Specifically, the presented research documents how fast the AMBA Interconnect of Xilinx’s Zynq-7000 Extensible Processing Platform functions by measuring the time taken to communicate between the Zynq EPP’s Dual-core ARM Cortex-A9 processor running FreeRTOS in Asymmetric Multiprocessing mode and programmable logic (PL) under several varied parameters, such as payload size, number of executing threads on each core, and type of interface utilized to access the PL. In addition, how an entire embedded design project is constructed with Xilinx’s Vivado Design Suite, namely the Vivado IDE and Software Development Kit, is demonstrated. The embedded design project is tested for both Avnet’s Zynq and Evaluation Board (Zedboard) and Xilinx’s ZC702 Evaluation Kit.

Andrew Powell is a recipient of Temple University’s Future Faculty Fellowship. He graduated with a B.S. in Electrical Engineering from Temple University. His advisor is Dennis Silage, Ph.D., professor in the Department of Electrical and Computer Engineering.

Collin Stabler: A regenerative engineer who rebuilds the vasculature in tissue-engineered lungs

Bioengineering Ph.D. candidate Collin Stabler's research focuses on regenerative medicine and tissue engineering of the lung. Mentored by Peter I. Lelkes, Laura H. Carnell Professor and Chair of the Department  of Bioengineering, Collin has taken to addressing a clear and present clinical need for engineered lung replacements to aid those waiting for a lung transplants. Specifically, Collin uses whole organ engineering approaches that utilize the lung’s natural, complex structure in a rat model. Once the cells in a cadaveric donor lung are removed, the different compartments of the decellularized lung are then re-seeded with diverse living cells, such as pulmonary epithelial cells and endothelial cells.  Collin’s PhD dissertation research sheds light on the complexities of re-building the vasculature in these bioengineered lungs by focusing on the mechanisms of how the re-seeded endothelial cells distribute and adhere within the multiple branches of the vasculature of decellularized lungs, and how these re-endothelialized blood vessels regain their functionality. This work has thus far led to several invited talks at international meetings such as the 2014 Biomedical Engineering Society conference in San Antonio, Texas, the 2014 Vermont Stem Cell and Lung Disease conference in Burlington, Vermont and the 2015 Tissue Engineering and Regenerative Medicine Society conference in Boston, Massachusetts. In addition to a first-authored research paper that is currently under review, Collin Stabler has also recently published a critical review paper of the field1 as well as contributed to several research articles that aim to bioengineer the lungs.

 

Figure Legend: Z- stack confocal images of rat lung microvessel endothelial cells cultured for 48h in decellularized lung. Scale bar = 85 nm, Blue = nuclei, Red = F-actin.  Reseeding of the vasculature in an engineered rat lung with capillary endothelial cells. 

1: Stabler CT, Lecht S, Mondrinos MJ, Goulart E, Lazarovici P, and Lelkes PI. Revascularization of Decellularized Lung Scaffolds: Principles and Progress. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 25:ajplung.00237.2015. doi: 10.1152/ajplung.00237.2015.