The focus of Temple Biomechanics Lab (TBL) is constitutive modeling of aorta and brain tissues and injury biomechanics of aortic rupture and traumatic brain injury. We utilize state-of-the-art experimental and computational methods to study tissues rate dependence, nonlinearity, heterogeneity, anisotropy, and damage at macroscopic and cellular scales. The research at TBL has been primarily funded by the NIH, American Heart Association, US Navy, and Depuy Spine in addition to internal supports and has resulted in multiple peer-reviewed publications. Our research is interdisciplinary in nature and as such involves several important collaborative efforts with Temple Medical School and Bioengineering faculty, including a long-term collaboration with Dr. Mary Barbe (Anatomy and Cell Biology) to develop injury metrics in TBI models and one with Dr. Michael Autieri (Cardiovascular Research Center) to study the microstructure of aortic dissection. Several orthopedic-related projects have also been conducted at TBL in collaboration with Dr. Saqib Rehman (Orthopedic Surgery), Dr. Asif Ilyas and Dr. Christopher Jones (Rothman Institute), and others.
At TBL, we have developed several cutting-edge research techniques related to aorta and brain biomechanics including a deceleration sled to study injuries in porcine aorta and rat brain, a shock tube to study blast-rate deformations in brain tissue, and a high-rate nanoindentation test setup for determination of material properties at the scale of a few micrometers. Currently, five graduate students and one post-doc (Dr. Declan Patton) are working in the lab.
PhD candidate Soroush Assari received an American Heart Association Pre-doctoral award for two years.
The aims of Soroush’s study are: a) To characterize cerebrovascular blood pressure rise and BBB permeability changes in “Head-Only” and “Chest-Only” exposures to blast wave in a rat-model; and b) To determine local stress-strain in cerebral vessels wall and perivascular brain tissue due to the blast-induced cerebral blood pressure wave using finite element analysis (FEA).
Drs. Mobin Rastgar Agah and Hossein Ghodsi graduated.
Graduation day of Mobin and Hossein (May 2015)
The title of Mobin’s PhD dissertation is “Material Characterization of Aortic Tissue for Traumatic Injury and Buckling”. The main topics of his work include a) Mechanical behavior of aorta in supra-physiological intraluminal pressures, b) Multirate mechanical behavior and failure properties of aortic tissue, and c) Mechanical instability of aorta due to intraluminal pressure.
The title of Hossein’s PhD dissertation is “Characterization of Multi-Scale Constitutive Model of Collagen: A Molecular Dynamics Modeling Approach”. The main topics of his work include a) Viscoelastic modeling of collagen molecule, b) Collagen cross-link modeling, and c) Collagen fibril modeling.
Dr. Darvish received an Undergraduate fellowship grant to train five undergraduate students in the broad area of cardiovascular bioengineering in the summer of 2015 and 2016
The goal of this project is to motivate talented undergraduate students to pursue advanced degrees or careers in the areas related to cardiovascular physiology and diseases with particular emphasis on bioengineering technologies.
Our research on aortic injury was featured in Philadelphia Inquirer
Drs. Kaveh Laksari and Ali Hemmasizadeh graduated.
Graduation day of Kaveh and Ali (May 2014)
The title of Kaveh’s PhD dissertation is “Nonlinear Viscoelastic Wave Propagation in Brain Tissue”. The main topics of his work include a) Constitutive model for brain tissue under finite compression, b) Mechanical response of brain tissue under blast loading, and c) Computational simulation of the mechanical response of brain tissue under blast loading. Kaveh was an AHA pre-doctoral fellow and is currently working as a post-doc at Stanford University.
The title of Ali’s PhD dissertation is “Characterization of Heterogeneous Material Properties of Aorta Using Nanoindentation”. The main topics of his work include a) Characterization of changes to the mechanical properties of arteries due to cold storage, b) Multilayer material properties of aorta, and c) Determination of correlations between mechanical and morphological properties of aorta. Ali is currently working at MSC software in Newport Beach, CA.
Our research on aortic injury was featured in Temple Magazine
Alan Kaufman graduated with MS degree. The title of his project is “Biomechanical Comparison of Meniscal Repair Systems in Shear Loading”.
Julie Miller graduated with ME degree. The title of her project is “Creating a Rigid Body Finite Element Model of the Wrist for Instability Considerations”.
Dr. Mehdi Shafieian graduated.
The title of Mehdi ‘s PhD dissertation is “Toward a Universal Constitutive Model for Brain Tissue”. The main topics of his work include a) Material Properties in Medium Rate Deformations, b) Material Properties in Blast Rate Deformations, and c) Development of the universal constitutive model. Mehdi is currently an assistant professor at Amirkabir University (Polytechnic) in Tehran, Iran.
Jing Bao graduated with MS degree. The title of her thesis is “Evaluation of the Approximations Involved in Analyzing High Rate Shear Experiments of Brain Tissue Using Finite Element Analysis”.
Lab group photo (2011)
Vasily Romanov graduated with MS degree. The title of his thesis is “Material Properties of Aorta from Biaxial Oscillatory Pressure Tests”. Vasily is currently working in Philadelphia.
Ji Chen graduated with MS degree. The title of his thesis is “Design and Usability of a System for the Study of Head Orientation”.
Cristina Parenti graduated with MS degree. The title of her thesis is “Variation of the Local Material Properties of Aorta Determined through Micro and Nano Indentation”. Cristina is currently working in Rome, Italy.
Graduation day of Ji, Nazanin, Kaveh (MS), and Cristina (May 2010)
Biomechanics of Arteries Mini-symposium was held at Temple. The goal of this Mini-symposium was to present and discuss recent advances in the mechanics of arteries with a particular focus on ruptures and injuries. The invited speakers were (in the order of their presentation) Dr. King Yang (Wayne State University), Dr. David Vorp (University of Pittsburgh), Dr. Jafar Vossoughi (University of Maryland), Dr. Michael Sacks (University of Pittsburgh), Dr. Alexander Rachev (Georgia Tech), Dr. Richard Kent (University of Virginia), and Dr. Warren Hardy (Virginia Tech). The Symposium was funded by Dr. Darvish’s NIH K25 grant and by the Mechanical Engineering Department.
Group photo with students at the end of the Mini-symposium (November, 2009)