Nancy Pleshko

Professor, Bioengineering

Office Hours

Room 817
Monday, 4:00-5:30 PM
Thursday, 12:30 - 2:00 PM

Bio

Dr. Nancy Pleshko is a Professor in the Department of Bioengineering at Temple University, Philadelphia, PA.  Dr. Pleshko is recognized for her research on assessment of tissues at the molecular, cellular, and structural level through application of state-of-the-art vibrational spectroscopy. She has substantial expertise in basic and translational research in connective tissue pathophysiology and orthopedics, including osteoporosis and other bone pathologies, and osteoarthritis and cartilage repair. She has over 90 publications, and has received over $5 million in federal funding.  

Degrees

  • B.Sc. Chemistry, McGill University, Montreal, Que, Canada 1985
  • M.S. Chemistry, Rutgers University, Newark, NJ  1988
  • Ph.D Chemistry, Rutgers University, Newark, NJ 1991

Academic Appointments

  • Professor, Dept. of Bioengineering, Temple University, January 2012 – present
  • Research Professor, Dept. of Mechanical Engineering, Temple University, 2009 - 2011
  • Associate Scientist, Hospital for Special Surgery, New York, NY, 1999 - 2007

Recent Publications 

  • Hanifi A, Richardson JB, Kuiper JH, Roberts S, Pleshko N.  Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters. Osteoarthritis Cartilage. 2012 Sep;20(9):988-96 
  • Bargman R, Posham R, Boskey A, Carter E, DiCarlo E,  Verdelis K, Raggio C, Pleshko N. High and Low Dose OPG-Fc Cause Osteopetrosis-Like Changes in Infant Mice. Pediatric Research,  2012 Nov;72(5):495-501 . Epub Aug 27 2012
  • Hanifi A, Bi X,  Yang X, Kavukcuoglu NB, Lin PC, DiCarlo E, Spencer RG, Bostrom MPG, Pleshko N.  Infrared Fiber Optic Probe Evaluation of Degenerative Cartilage Correlates to Histological Grading. American Journal Sports Medicine, 2012 Dec;40(12):2853-61 
  • Hanifi A, McGoverin C, Ou YT, Safadi F, Spencer RG, Pleshko N. Differences in infrared spectroscopic data of connective tissues in transflectance and transmittance modes. Anal Chim Acta, in press
  • Hanifi A, McCarthy H,  Roberts A,  Pleshko N.  Fourier Transform Infrared Imaging and Infrared Fiber Optic Probe Spectroscopy Identify Collagen Type in Connective Tissues. PloS One, in press   

Research Interest

  • Molecular imaging of tissues and cells
  • Application and development of spectroscopic analysis techniques to cartilage and bone pathologies
  • Tissue engineering
  • Contribution of molecular alterations in connective tissues to mechanical behavior
  • MicroCT and magnetic resonance imaging of connective tissues.

Funding Sources

  • NIH
  • OI Foundation
  • National Medical Technology Testbed

Link to the Pleshko Lab