Cezary Marcinkiewicz

Associate Research Professor in Bioengineering

Office Hours

Room 920
Monday: 11:00 AM - 1:00 PM
Friday: 11:00 AM - 12:00 PM

Bio

Dr. Cezary Marcinkiewicz is an Adjunct Professor in the Departments of Bioengineering and Civil Engineering at Temple University, Philadelphia, PA. Dr. Marcinkiewicz is internationally recognized for work with snake venom proteins that interact with cell surface receptors, integrins, in context regulation of angiogenesis. He is extensively published and his work has been funded by National Institute of Health, American Heart Association, W.W. Smith Charitable Trust and National Multiple Sclerosis Society.

Degrees

  • PhD. Biochemistry, Medical School of Białystok, Poland, 1992
  • M.Sc. Chemistry, University of Warsaw, Poland, 1986

Academic Appointments 

  • 7/2005 – 7/2008 Assistant Professor, Dept. Neuroscience Temple University, School of Medicine
  • 7/1/2008 – 6/30/2013 Associate Professor, Dept. Biology Temple University, College of Science and Technology
  • 7/1/2013 – present Associate Professor, Dept. Bioengineering Temple University, College of Engineering

Recent Publications

  • Walsh E.M., Kim R., Weaver M., Luis Del Valle, Sheffield J., Lazarovici P., Marcinkiewicz C. 2012. Importance of interaction of NGF with integrin in progression of glioma angiogenesis. Neuro.-Oncol. 14, 890-901.
  • Ettinger K, Lecht S, Arien-Zakay H, Cohen G, Aga-Mizrachi S, Yanay N, Saragovi HU, Nedev H, Marcinkiewicz C, Nevo Y, Lazarovici P. 2012. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75(NTR) and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model. Cell Signal. 24, 2378-2388.
  • Arlinghaus FT, Momic T, Ammar NA, Shai E, Spectre G, Varon D, Marcinkiewicz C, Heide H, Lazarovici P, Eble JA. 2013. Identification of α2β1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae. Toxicon 64, 96-105
  • Jakubowski P., Calvete J.J., Eble J.A., Lazarovici P., Marcinkiewicz C. 2013. Identification of C-lectin type proteins in Echis suchoreki venom, which interact with integrin. Toxicol. Appl. Pharmacol. 269, 34-42.
  • Marcinkiewicz C. 2013. Applications of snake venom components to modulate integrin activities in cell-matrix interactions. Int. J. Biochem. Cell Biol. 45, 1974-1986 (invited review)

Research Interest

Dr. Cezary Marcinkiewicz research is focused on investigation of integrins involved in angiogenesis. Several snake venom disintegrins and C-type lectin proteins were discover in laboratory of Dr. Marcinkiewicz. These compounds are investigated as regulators of new vessels formation for potential application in many biomedical targets such as cancer and regenerative medicine.

Funding Sources

NIH R01